2025
Harnessing HIV clinics to deliver integrated hypertension care for People living with HIV in Uganda: A formative mixed methods study
Semitala F, Ayebare F, Kiggundu J, Kiwala C, Senfuma J, Mutungi G, Ssinabulya I, Kayima J, Muddu M, Spiegelman D, Schwartz J, Longenecker C, Katahoire A. Harnessing HIV clinics to deliver integrated hypertension care for People living with HIV in Uganda: A formative mixed methods study. PLOS Global Public Health 2025, 5: e0004701. PMID: 40465676, PMCID: PMC12136366, DOI: 10.1371/journal.pgph.0004701.Peer-Reviewed Original ResearchFragmented care deliveryHypertension careQualitative dataHIV clinicSub-Saharan AfricaCare deliveryConsolidated Framework for Implementation ResearchAnalyzed qualitative dataQualitative interviewsInterruptions due to side effectsSub-SaharanHIV servicesBlood pressureHealthcare accessNon-communicable diseasesMixed methods studyUgandaPeri-urban UgandaChronic careSystolic blood pressureHIV careImplementation researchPocket costsMedication accessAnalyzed quantitative dataPrimary Tumors of the Brain and Central Nervous System in Adults and Children in Sub-Saharan Africa: Protocol for a Scoping Review
Al-Fikri A, Alhammadi M, Arum C, Kaur M, Del Biondo K, Bani I, Mudenda V, Vermund S. Primary Tumors of the Brain and Central Nervous System in Adults and Children in Sub-Saharan Africa: Protocol for a Scoping Review. JMIR Research Protocols 2025, 14: e66978. PMID: 40273436, PMCID: PMC12062764, DOI: 10.2196/66978.Peer-Reviewed Original ResearchConceptsINTERNATIONAL REGISTERED REPORT IDENTIFIERInternational Agency for Research on CancerSub-Saharan AfricaScoping ReviewIndependent reviewersIncidence rateCentral nervous systemFull-text screeningLow-resource settingsCentral nervous system cancerSub-SaharanNeurosurgery facilityPRISMA-ScRLow incidence rateGlobal health organizationsEvidence synthesisService gapsReviewed titlesGrey literaturePRISMA-PAbstract screeningTreatment of CNS tumorsCentral nervous system tumorsOvid MEDLINEEligibility criteriaA systematic review of variables associated with snakebite risk in spatial and temporal analyses
Collinson S, Lamb T, Cardoso I, Diggle P, Lalloo D. A systematic review of variables associated with snakebite risk in spatial and temporal analyses. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 2025, trae131. PMID: 39817354, DOI: 10.1093/trstmh/trae131.Peer-Reviewed Original ResearchSystematic reviewJoanna Briggs Institute toolHealth facility reportingRisk estimation accuracyWeb of ScienceNarrative synthesisFacility reportsStudy qualityAd hoc surveyResearch availabilityHigh-risk regionsIncidence dataSub-Saharan AfricaUrban residentsGlobal healthPositive associationSnakebite riskInstitutional toolsRisk variationStatistical associationNegative associationSub-SaharanCase incidenceAssociationRiskGlobal variation in the assessment of psychological trauma in pregnancy
Wall K, Penner F, Goldman L, Shin J, Novak E, Lowell A, Day M, Papa L, Wright D, Givrad S, Rutherford H. Global variation in the assessment of psychological trauma in pregnancy. Cambridge Prisms Global Mental Health 2025, 12: e10. PMID: 39935728, PMCID: PMC11810758, DOI: 10.1017/gmh.2024.152.Peer-Reviewed Original ResearchSub-Saharan AfricaPregnant peopleSystematic reviewPsychological traumaImpact health outcomesMiddle EastIn-house assessmentPrevalence of traumatic experiencesCulturally appropriate measuresPreferred Reporting ItemsTraumatic experiencesObstetric careWeb of ScienceHealth outcomesCentral AmericaReporting ItemsSecondary analysisOvid MEDLINESub-SaharanOvid EmbaseSystematic literature reviewGeopolitical regionsAssessment of psychological traumaAfricaInterpersonal traumaSubstance Use Disorders Among Young People Living with HIV in Sub-Saharan Africa: Insights from a Cohort Study in Ghana
Ikekwere J, Eiger R, Heward B, Antwi R, Ugwu V, Fagbenle O, Ishola A, Enimil A, Omuojine J, Dickens C, Jegede O, Oladunjoye A, Bosomtwe D, Ogieuhi I, Emojevwe V, Babalola A, Ajekiigbe V. Substance Use Disorders Among Young People Living with HIV in Sub-Saharan Africa: Insights from a Cohort Study in Ghana. Medical Research Archives 2025, 13 DOI: 10.18103/mra.v13i4.6422.Peer-Reviewed Original ResearchPrevalence of substance use disordersSubstance use disordersKomfo Anokye Teaching HospitalReduced adherence to antiretroviral therapySubstance Involvement Screening TestCohort studyAdherence to antiretroviral therapyIncreased risk of HIV transmissionUse disorderSub-Saharan AfricaYoung peopleWorsened health outcomesRisk of HIV transmissionBurden of substance use disordersSubstance useEstimated overall prevalenceSub-SaharanPrevention counselingPublic health concernHealth outcomesHIV statusHIV transmissionTeaching hospitalRegular counselingReceiving treatment
2024
S1894 The Burden of Liver Cancer in Sub-Saharan Africa: An Analysis From the Global Burden of Disease Database
Al Ta'ani O, Al-Ajlouni Y, Alhalalmeh Y, Almasaid S, Muzammil T, Daniel T, Njei B. S1894 The Burden of Liver Cancer in Sub-Saharan Africa: An Analysis From the Global Burden of Disease Database. The American Journal Of Gastroenterology 2024, 119: s1361-s1361. DOI: 10.14309/01.ajg.0001036944.57871.17.Peer-Reviewed Original ResearchCosts of HIV testing services in sub-Saharan Africa: a systematic literature review
Ahmed N, Ong J, McGee K, d’Elbée M, Johnson C, Cambiano V, Hatzold K, Corbett E, Terris-Prestholt F, Maheswaran H. Costs of HIV testing services in sub-Saharan Africa: a systematic literature review. BMC Infectious Diseases 2024, 22: 980. PMID: 39192180, PMCID: PMC11348535, DOI: 10.1186/s12879-024-09770-7.Peer-Reviewed Original ResearchConceptsHIV testing servicesHome-basedSub-Saharan AfricaTesting servicesGeneral populationHIV testing modalitiesHIV self-testingSystematic literature reviewSub-SaharanHIV-positive personsResultsSixty-five studiesTesting modalitiesHIV testingHealth facilitiesSelf-testingElectronic databasesLiterature reviewIncremental cost estimatesMale partnersIncremental costPrimary testHIVCost estimatesCampaign-styleServicesGlobal and Regional Cardiovascular Mortality Attributable to Nonoptimal Temperatures Over Time
Hundessa S, Huang W, Zhao Q, Wu Y, Wen B, Alahmad B, Armstrong B, Gasparrini A, Sera F, Tong S, Madureira J, Kyselý J, Schwartz J, Vicedo-Cabrera A, Hales S, Johnson A, Li S, Guo Y, Jaakkola J, Ryti N, Urban A, Tobias A, Royé D, Lavigne E, Ragettli M, Åström C, Raz R, Pascal M, Kan H, Goodman P, Zeka A, Hashizume M, Diaz M, Seposo X, Nunes B, Kim H, Lee W, Íñiguez C, Guo Y, Pan S, Zanobetti A, Dang T, Van Dung, Schneider A, Entezari A, Analitis A, Forsberg B, Ameling C, Houthuijs D, Indermitte E, Mayvaneh F, Acquaotta F, de'Donato F, Carrasco-Escobar G, Orru H, Katsouyanni K, de Sousa Zanotti Stagliorio Coelho M, Ortega N, Scovronick N, Michelozzi P, Correa P, Saldiva P, Abrutzky R, Osorio S, Colistro V, Huber V, Honda Y, Kim Y, Bell M, Xu R, Yang Z, Roradeh H, Arellano E, Rao S, Chua P, da Silva S, da Silva S, De la Cruz Valencia C. Global and Regional Cardiovascular Mortality Attributable to Nonoptimal Temperatures Over Time. Journal Of The American College Of Cardiology 2024, 83: 2276-2287. PMID: 38839202, DOI: 10.1016/j.jacc.2024.03.425.Peer-Reviewed Original ResearchConceptsCardiovascular deathCardiovascular mortalityExcess mortality ratesCardiovascular mortality riskMultivariate meta-regression modelTemperature-mortality associationsMeta-regression modelsTemperature-related deathsMortality burdenMortality riskEffect estimatesHeat-related deathsSub-Saharan AfricaMortality attributesTemporal trendsCold-related deathsMortality rateGlobal assessmentSub-SaharanInvestigated spatiotemporal trendsDeath ratioMortalityBurdenComprehensive global assessmentDeathHepatitis B
Khungar V, Han T. Hepatitis B. 2024, 227-235. DOI: 10.1201/9781003524489-36.Peer-Reviewed Original ResearchA Comparison of Markov and Mechanistic Models for Soil-Transmitted Helminth Prevalence Projections in the Context of Survey Design
Eyre M, Bulstra C, Johnson O, de Vlas S, Diggle P, Fronterrè C, Coffeng L. A Comparison of Markov and Mechanistic Models for Soil-Transmitted Helminth Prevalence Projections in the Context of Survey Design. Clinical Infectious Diseases 2024, 78: s146-s152. PMID: 38662703, PMCID: PMC11045013, DOI: 10.1093/cid/ciae022.Peer-Reviewed Original ResearchConceptsOptimal survey designImpact assessment surveysSurvey designProjected prevalenceGeostatistical methodsPrevalence surveySampling designSchool-aged childrenPreventive chemotherapySoil-Transmitted HelminthsPrevalence projectionsControl programsWorld Health OrganizationAssessment surveyPrevalence dataSub-Saharan AfricaMechanistic modelTarget of PCSoutheast AsiaHealth OrganizationMechanistic methodsPrevalenceBillion peopleSub-SaharanInadequate sanitationAccuracy of and preferences for blood-based versus oral-fluid-based HIV self-testing in Malawi: a cross-sectional study
O’Reilly A, Mavhu W, Neuman M, Kumwenda M, Johnson C, Sinjani G, Indravudh P, Choko A, Hatzold K, Corbett E. Accuracy of and preferences for blood-based versus oral-fluid-based HIV self-testing in Malawi: a cross-sectional study. BMC Infectious Diseases 2024, 22: 979. PMID: 38566003, PMCID: PMC10985843, DOI: 10.1186/s12879-024-09231-1.Peer-Reviewed Original ResearchConceptsBlood-basedHIV-positiveOral fluidFactors associated with preferenceBlood-based testHIV testing servicesMultivariate logistic regressionFacility-based servicesHIV self-testingBackgroundHIV self-testingSelf-testingSelf-administered questionnaireCross-sectional studySemi-structured questionnaireAssociated with choiceHIVSTSociodemographic dataConfirmatory testTesting servicesLogistic regressionSub-Saharan AfricaUrban MalawiSub-SaharanQuestionnaireUrban facilitiesReview of Genetic and Artificial Intelligence approaches to improving Gestational Diabetes Mellitus Screening and Diagnosis in sub-Saharan Africa
Gadhia V, Loyal J. Review of Genetic and Artificial Intelligence approaches to improving Gestational Diabetes Mellitus Screening and Diagnosis in sub-Saharan Africa. The Yale Journal Of Biology And Medicine 2024, 97: 67-72. PMID: 38559462, PMCID: PMC10964814, DOI: 10.59249/zbsc2656.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitus screeningGestational diabetes mellitusSub-Saharan AfricaSingle nucleotide polymorphismsBarriers to successful integrationImplementation of AISub-Saharan African womenSub-SaharanPredictor of gestational diabetes mellitusRisk of gestational diabetes mellitusAssociated with gestational diabetes mellitusDiabetes mellitus screeningEarly identificationBlack South African cohortTrimester of pregnancySouth African cohortSub-Saharan African populationsHealthcare systemImprove screeningResource settingsSub-Saharan African regionField of healthcareGenetic variantsGoogle ScholarAfrican cohortCost-effectiveness of a pediatric operating room installation in Sub-Saharan Africa
Yap A, Halid S, Ukwu N, Laverde R, Park P, Klazura G, Bryce E, Cheung M, Marseille E, Ozgediz D, Ameh E. Cost-effectiveness of a pediatric operating room installation in Sub-Saharan Africa. PLOS Global Public Health 2024, 4: e0001748. PMID: 38536860, PMCID: PMC10971580, DOI: 10.1371/journal.pgph.0001748.Peer-Reviewed Original ResearchDisability-adjusted life yearsPediatric operating roomIncremental cost-effectiveness ratioSub-Saharan AfricaSurgical infrastructureProbabilistic sensitivity analysesOperating roomLocal healthcare systemCost-effective interventionPayor perspectiveCost-effectiveSub-SaharanHealth outcomesPediatric surgical servicesSurgical capacityCost-effectiveness thresholdPatient's familyCost-effectiveness ratioHealthcare systemLack of knowledgeGlobal surgerySurgical deliveryUnited States dollarsLife yearsSurgical servicesCreating a Sustainable Foundation for IR Services and Training in Sub-Saharan Africa: 5-Year Update on the Road2IR Initiative
Alswang J, Mbuguje E, Chan S, Ak M, Naif A, Rukundo I, Minja F, Newsome J, Ramalingam V, Laage Gaupp F. Creating a Sustainable Foundation for IR Services and Training in Sub-Saharan Africa: 5-Year Update on the Road2IR Initiative. Journal Of Vascular And Interventional Radiology 2024, 35: 1049-1056. PMID: 38513756, DOI: 10.1016/j.jvir.2024.03.015.Peer-Reviewed Original ResearchTechnical success rateMinimally invasive procedureInterventional radiology serviceSub-Saharan AfricaClinical outcomesProcedural dataResource-constrained settingsInvasive proceduresIR physiciansPrimary operationTeaching hospitalSuccess rateSub-SaharanStudy periodComplicationsProcedure classNon-vascularHands-on trainingRadiology servicesFive-yearIncreased Stigma, and Physical and Sexual Violence Against Men Who Have Sex with Men and Transgender Women in Sub-Saharan Africa: A Qualitative Evidence Synthesis Analyzing Social and Structural Barriers to HIV Testing and Coping Behaviors
Thapa S, Ogunleye T, Shrestha R, Joshi R, Hannes K. Increased Stigma, and Physical and Sexual Violence Against Men Who Have Sex with Men and Transgender Women in Sub-Saharan Africa: A Qualitative Evidence Synthesis Analyzing Social and Structural Barriers to HIV Testing and Coping Behaviors. Journal Of Homosexuality 2024, 72: 245-271. PMID: 38456684, DOI: 10.1080/00918369.2024.2320237.Peer-Reviewed Original ResearchTransgender womenHIV testing servicesStructural barriersSub-Saharan AfricaSub-SaharanSub-Saharan African countriesSame-sex relationshipsHIV testingTesting servicesFear of discriminationAnalyzing socializationPhysical violenceSex relationshipsHIV testing uptakeLack of trustAfrican countriesQualitative evidence synthesisPoor accessIncreased stigmaRisky behaviorsCriminalsQualitative studyMSMTesting uptakeNon-disclosureMapping the incidence rate of typhoid fever in sub-Saharan Africa
Kim J, Choi J, Kim C, Pak G, Parajulee P, Haselbeck A, Park E, Mogasale V, Jeon H, Browne A, Owusu-Dabo E, Rakotozandrindrainy R, Bassiahi A, Teferi M, Lunguya-Metila O, Dolecek C, Pitzer V, Crump J, Hay S, Marks F. Mapping the incidence rate of typhoid fever in sub-Saharan Africa. PLOS Neglected Tropical Diseases 2024, 18: e0011902. PMID: 38408128, PMCID: PMC10965079, DOI: 10.1371/journal.pntd.0011902.Peer-Reviewed Original ResearchIncidence rateSub-Saharan AfricaRate of typhoid feverTyphoid feverIncidence rate of typhoid feverIncidence rate estimatesEffective intervention programsEstimated incidence ratePublic health problemSub-SaharanHigh-incidence countriesLow-incidence countriesHealth conditionsIntervention programsDisease riskHealth problemsTarget resourcesGeospatial variationAge classesDisease incidenceEnvironmental conditionsPublished articlesSub-national heterogeneityGeospatial covariatesCultures of bloodScoping review of HIV-related intersectional stigma among sexual and gender minorities in sub-Saharan Africa
Dada D, Abu-Ba’are G, Turner D, Mashoud I, Owusu-Dampare F, Apreku A, Ni Z, Djiadeu P, Aidoo-Frimpong G, Zigah E, Nyhan K, Nyblade L, Nelson L. Scoping review of HIV-related intersectional stigma among sexual and gender minorities in sub-Saharan Africa. BMJ Open 2024, 14: e078794. PMID: 38346887, PMCID: PMC10862343, DOI: 10.1136/bmjopen-2023-078794.Peer-Reviewed Original ResearchConceptsSub-Saharan AfricaHIV-related stigmaIntersectional stigmaIntersectional lensHIV vulnerabilityIntersectional approachGender non-conformity stigmaStigma researchScoping ReviewSystems of oppressionMeta-Analysis extensionWorsening mental healthGender minoritiesTransgender individualsHIV risk factorsPreferred Reporting ItemsStigmatised identitySGM populationsStigma driversHIV riskStigmatised populationsService uptakeNegative health effectsSub-SaharanSocioecological levelsHigh prevalence of impaired glucose metabolism among children and adolescents living with HIV in Ghana
Ayanful‐Torgby R, Shabanova V, Essuman A, Boafo E, Aboagye F, Al‐Mahroof Y, Amponsah J, Tetteh J, Amoah L, Paintsil E. High prevalence of impaired glucose metabolism among children and adolescents living with HIV in Ghana. HIV Medicine 2024, 25: 577-586. PMID: 38240173, PMCID: PMC11078607, DOI: 10.1111/hiv.13614.Peer-Reviewed Original ResearchPrevalence of impaired glucose metabolismWaist-to-hip ratioBody mass indexFasting blood sugarImpaired glucose metabolismHOMA-IRCorrelations of Waist-to-hip ratioSub-Saharan AfricaAged 6Glucose metabolismDevelopment of metabolic syndrome in adulthoodAntiretroviral treatment clinicsAssociated with fasting blood sugarWaist-to-hipHighest prevalenceAge groupsCross-sectional studyMetabolic syndrome in adulthoodInsulin resistancePathogenesis of impaired glucose metabolismOlder age groupsEastern Region of GhanaSub-SaharanSyndrome in adulthoodGlucose metabolism markers
2023
The coevolutionary mosaic of bat betacoronavirus emergence risk
Forero-Muñoz N, Muylaert R, Seifert S, Albery G, Becker D, Carlson C, Poisot T. The coevolutionary mosaic of bat betacoronavirus emergence risk. Virus Evolution 2023, 10: vead079. PMID: 38361817, PMCID: PMC10868545, DOI: 10.1093/ve/vead079.Peer-Reviewed Original ResearchSpatially explicit frameworkGeographic mosaic theory of coevolutionHost richnessGeographies of riskExplicit frameworkGeographic mosaic theoryTheory of coevolutionGlobal biogeographySub-Saharan AfricaDisease emergencePathogen evolutionEvolutionary riskSub-SaharanViral emergenceMiddle EastHotspotsSoutheast Asia“If you have light, your heart will be at peace”: A qualitative study of household lighting and social integration in southwestern Uganda
Ponticiello M, Nuwagira E, Tayebwa M, Mugerwa J, Nahabwe H, Nakasita C, Tumuhimbise J, Lam N, Wiens M, Vallarino J, Allen J, Muyanja D, Tsai A, Sundararajan R, Lai P. “If you have light, your heart will be at peace”: A qualitative study of household lighting and social integration in southwestern Uganda. Journal Of Global Health 2023, 13: 04026. PMID: 37052216, PMCID: PMC10099441, DOI: 10.7189/jogh.13.04026.Peer-Reviewed Original ResearchConceptsSocial integrationImprove social integrationSocial healthRural UgandaImprove feelings of safetyLived experienceStigma of povertyLighting interventionQualitative sub-studyRandomized wait-list controlled trialFeelings of safetyImpact of interventionsImproved Self-EsteemOne-on-oneSub-Saharan AfricaSense of well-beingSustainable Development GoalsHousehold relationshipsQualitative interviewsQualitative studyStudy participantsDevelopment GoalsSouthwestern UgandaSub-SaharanIndividual-level
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