Insulin action and binding in isolated hepatocytes from fasted, streptozotocin-diabetic, and older, spontaneously obese rats
Cech J, Freeman R, F. J, Amatruda J. Insulin action and binding in isolated hepatocytes from fasted, streptozotocin-diabetic, and older, spontaneously obese rats. Biochemical Journal 1980, 188: 839-845. PMID: 7008780, PMCID: PMC1161968, DOI: 10.1042/bj1880839.Peer-Reviewed Original ResearchConceptsObese ratsInsulin-stimulated uptakeDose-response curveDiabetic animalsInsulin resistanceAminoisobutyrate uptakeDecreased maximal responseStreptozotocin-diabetic ratsBasal rateYoung control animalsYoung control ratsInsulin receptorControl cellsOld obese ratsConcentrations of insulinDose-response relationshipEnhanced basal rateMaximal insulin responsivenessHalf-maximal responseNumber of receptorsIsolated hepatocytesStreptozotocin-diabeticMore insulinControl ratsInsulin response
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