1982
Glucocorticoid-induced Insulin Resistance
F. J, Amatruda J. Glucocorticoid-induced Insulin Resistance. Journal Of Clinical Investigation 1982, 69: 866-875. PMID: 7042756, PMCID: PMC370141, DOI: 10.1172/jci110526.Peer-Reviewed Original ResearchConceptsAbility of insulinControl animalsInsulin bindingInsulin degradationDexamethasone treatmentNormal ratsInsulin receptorInsulin actionAminoisobutyrate uptakeWeight-matched control animalsGlucocorticoid-induced insulin resistancePrimary culturesAdministration of dexamethasoneDexamethasone-treated animalsPresence of hyperinsulinemiaEffect of insulinCellular insulin receptorsDose-response curveHepatocyte insulin receptorsSignificant hyperinsulinemiaInsulin resistanceAbsence of dexamethasoneLess insulinInsulin concentrationsVivo hyperinsulinemia
1980
Insulin action and binding in isolated hepatocytes from fasted, streptozotocin-diabetic, and older, spontaneously obese rats
Cech J, Freeman R, F. J, Amatruda J. Insulin action and binding in isolated hepatocytes from fasted, streptozotocin-diabetic, and older, spontaneously obese rats. Biochemical Journal 1980, 188: 839-845. PMID: 7008780, PMCID: PMC1161968, DOI: 10.1042/bj1880839.Peer-Reviewed Original ResearchConceptsObese ratsInsulin-stimulated uptakeDose-response curveDiabetic animalsInsulin resistanceAminoisobutyrate uptakeDecreased maximal responseStreptozotocin-diabetic ratsBasal rateYoung control animalsYoung control ratsInsulin receptorControl cellsOld obese ratsConcentrations of insulinDose-response relationshipEnhanced basal rateMaximal insulin responsivenessHalf-maximal responseNumber of receptorsIsolated hepatocytesStreptozotocin-diabeticMore insulinControl ratsInsulin response
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