2023
Maternal diabetes in youth-onset type 2 diabetes is associated with progressive dysglycemia and risk of complications
RD S, SD C, L E, ME G, J K, MM K, R F, B T, JB T, M V, E I. Maternal diabetes in youth-onset type 2 diabetes is associated with progressive dysglycemia and risk of complications. 2023 DOI: 10.1530/ey.20.10.7.Peer-Reviewed Original Research
2022
Maternal Diabetes in Youth-Onset Type 2 Diabetes Is Associated With Progressive Dysglycemia and Risk of Complications
Shah R, Chernausek S, ghormli L, Geffner M, Keady J, Kelsey M, Farrell R, Tesfaldet B, Tryggestad J, Van Name M, Isganaitis E. Maternal Diabetes in Youth-Onset Type 2 Diabetes Is Associated With Progressive Dysglycemia and Risk of Complications. The Journal Of Clinical Endocrinology & Metabolism 2022, 108: 1120-1131. PMID: 36446741, PMCID: PMC10306086, DOI: 10.1210/clinem/dgac663.Peer-Reviewed Original ResearchConceptsYouth-onset type 2 diabetesType 2 diabetesMaternal diabetesHeart rate variabilityGlomerular hyperfiltrationParental diabetesGlycemic controlRate variabilityFuture cardiometabolic diseaseParental diabetes historyYouth-onset T2D.Lower heart rate variabilityRisk of complicationsWorse glycemic controlΒ-cell functionRace/ethnicityDiabetes historyCardiometabolic diseasesDiabetes outcomesPrenatal exposureUS cohortGlycemic outcomesRisk factorsDisease progressionUS CentersGrowth patterns among late preterm infants of mothers with diabetes
Buck CO, Shabanova V, Taylor SN. Growth patterns among late preterm infants of mothers with diabetes. The Journal Of Maternal-Fetal & Neonatal Medicine 2022, 35: 10116-10123. PMID: 36075588, DOI: 10.1080/14767058.2022.2119125.Peer-Reviewed Original ResearchConceptsLate preterm infantsUnexposed infantsPreterm infantsFirst postnatal weekGreater weight gainDM groupMaternal diabetesWeight gainPostnatal weekWeight trajectoriesRetrospective longitudinal analysisAge 2 yearsLong-term riskAge twoCardiometabolic diseasesExposure groupDiabetesInfantsAverage weightGrowth patternHighest average weightTerm riskEarly childhoodFurther studiesPregnancyGenome-Wide De Novo Variants in Congenital Heart Disease Are Not Associated With Maternal Diabetes or Obesity
Morton SU, Pereira AC, Quiat D, Richter F, Kitaygorodsky A, Hagen J, Bernstein D, Brueckner M, Goldmuntz E, Kim RW, Lifton RP, Porter GA, Tristani-Firouzi M, Chung WK, Roberts A, Gelb BD, Shen Y, Newburger JW, Seidman JG, Seidman CE. Genome-Wide De Novo Variants in Congenital Heart Disease Are Not Associated With Maternal Diabetes or Obesity. Circulation Genomic And Precision Medicine 2022, 15: e003500. PMID: 35130025, PMCID: PMC9295870, DOI: 10.1161/circgen.121.003500.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseDamaging de novo variantsMaternal diabetesPrenatal exposureHeart diseaseDe novo variantsParental ageIncidence of CHDNovo variantsCauses of CHDMaternal obesityObese mothersDiabetes riskPatientsCommon anomalyObesityDiabetesAgeWhole-genome sequencingDiseaseMothersGene studiesCauseExposureInfants
2021
Imaging Review of Obstetric Sequelae of Maternal Diabetes Mellitus
Aboughalia H, Pathak P, Basavalingu D, Chapman T, Revzin MV, Sienas LE, Deutsch GH, Katz DS, Moshiri M. Imaging Review of Obstetric Sequelae of Maternal Diabetes Mellitus. RadioGraphics 2021, 42: 302-319. PMID: 34855544, DOI: 10.1148/rg.210164.Peer-Reviewed Original ResearchConceptsFetal lung maturityMaternal complicationsPerinatal morbidityCesarean deliveryCongenital anomaliesLung maturityTwo-vessel umbilical cordBrachial plexus palsyFetal growth restrictionMaternal-fetal medicineTime of deliveryAssociated preeclampsiaFetal complicationsPlacental thickeningMacrosomic fetusesMaternal outcomesPlacental abruptionPreterm laborDiabetic pregnanciesFetal macrosomiaHypertensive diseasePlexus palsyDiabetes mellitusHumeral fracturesMaternal diabetes19-OR: Maternal Diabetes Is Associated with Adverse Diabetes Characteristics and Accelerated Onset of Complications in Youth with Type 2 Diabetes (T2D) in TODAY
ISGANAITIS E, SHAH R, CHERNAUSEK S, FARRELL R, GEFFNER M, KEADY J, KELSEY M, TESFALDET B, TRYGGESTAD J, VAN NAME M. 19-OR: Maternal Diabetes Is Associated with Adverse Diabetes Characteristics and Accelerated Onset of Complications in Youth with Type 2 Diabetes (T2D) in TODAY. Diabetes 2021, 70 DOI: 10.2337/db21-19-or.Peer-Reviewed Original ResearchGlycemic controlAccelerated onsetDaiichi SankyoAdverse diabetes outcomesFuture cardiometabolic healthNegative islet autoantibodiesYouth-onset T2D.Type 2 diabetesMothers of participantsNovo NordiskSuccessive NN intervalsHeart rate variabilityGlomerular hyperfiltrationIslet autoantibodiesCardiometabolic healthDiabetes statusMaternal diabetesKidney diseaseDiabetes careDM diagnosisDohme Corp.Diabetes outcomesPrenatal exposureDiabetes characteristicsDiabetic retinopathy
2020
Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis
Jiang S, Teague A, Tryggestad J, Lyons T, Chernausek S. Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis. Molecular Medicine 2020, 26: 76. PMID: 32762639, PMCID: PMC7409642, DOI: 10.1186/s10020-020-00205-y.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAdultBiomarkersBlood GlucoseCase-Control StudiesDiabetes, GestationalDNA, MitochondrialFemaleFetal BloodHumansLeukocytes, MononuclearMaternal ExposureMesenchymal Stem CellsMitochondriaOrganelle BiogenesisPlacentaPregnancyPrenatal Exposure Delayed EffectsResistinStress, PhysiologicalTrophoblastsConceptsCord blood mononuclear cellsBlood mononuclear cellsSecretion of resistinHuman resistinMononuclear cellsBeWo cellsCultured cord blood mononuclear cellsMeasures of maternal glycemiaMesenchymal stem cellsLong-term health of offspringExposed BeWo cellsImpact fetal developmentPlacental mitochondrial contentCirculation of infantsPlacental trophoblast cellsHuman placental explantsAdipocyte-derived factorsHealth of offspringMaternal glycemiaResponse to high glucoseDiabetic pregnanciesFetal circulationMaternal diabetesCord bloodCord seraMaternal Diabetes During Pregnancy and Early Onset of Cardiovascular Disease in Offspring: Population Based Cohort Study With 40 Years of Follow Up
Yu Y, Arah O, Liew Z, Cnattingius S, Olsen J, Sørensen H, Qin G, Li J. Maternal Diabetes During Pregnancy and Early Onset of Cardiovascular Disease in Offspring: Population Based Cohort Study With 40 Years of Follow Up. Obstetrical & Gynecological Survey 2020, 75: 277-279. DOI: 10.1097/01.ogx.0000666220.44880.94.Peer-Reviewed Original Research
2019
Breastfeeding Initiation as Related to the Interaction of Race/Ethnicity and Maternal Diabetes
Stevens DR, Taylor SN, Roberts JR, Neelon B, Newman RB, Vena JE, Hunt KJ. Breastfeeding Initiation as Related to the Interaction of Race/Ethnicity and Maternal Diabetes. Breastfeeding Medicine 2019, 14: 630-639. PMID: 31364862, PMCID: PMC6857546, DOI: 10.1089/bfm.2019.0065.Peer-Reviewed Original ResearchConceptsBody mass indexPrepregnancy body mass indexRace/ethnicityFull-term birthNon-Hispanic black mothersDiabetes statusMaternal diabetesOdds ratioMaternal prepregnancy body mass indexMaternal diabetes statusMaternal metabolic disordersPopulation-based studyConfidence intervalsBlack mothersGestational diabetesBirth outcomesMass indexClinical variablesNegative health effectsBreastfeeding interventionsStudy populationAdditional adjustmentMetabolic disordersDiabetesHealth effects
2018
Regulation and Role of Human Resistin in Diabetes during Pregnancy
JIANG S, TEAGUE A, TRYGGESTAD J, LYONS T, CHERNAUSEK S. Regulation and Role of Human Resistin in Diabetes during Pregnancy. Diabetes 2018, 67 DOI: 10.2337/db18-1401-p.Peer-Reviewed Original ResearchCord blood mononuclear cellsDiabetic pregnanciesHuman resistinCultured cord blood mononuclear cellsMeasures of maternal glycemiaEffects of maternal diabetesLong-term health of offspringImpact fetal developmentOffspring of diabetic pregnancyPlacental trophoblast cellsBlood mononuclear cellsSecretion of resistinHuman term placentaAdipocyte-derived factorsHealth of offspringMaternal glycemiaResponse to high glucoseFetal circulationMaternal diabetesPlacental functionCord seraFetal developmentResistin levelsTerm placentaResistin concentrations
2017
Effects of maternal diabetes and fetal sex on human placenta mitochondrial biogenesis
Jiang S, Teague A, Tryggestad J, Aston C, Lyons T, Chernausek S. Effects of maternal diabetes and fetal sex on human placenta mitochondrial biogenesis. Placenta 2017, 57: 26-32. PMID: 28864016, PMCID: PMC5659203, DOI: 10.1016/j.placenta.2017.06.001.Peer-Reviewed Original ResearchConceptsMtDNA contentResponse to maternal diabetesMitochondrial biogenesisMitochondrial DNAPGC-1aEffects of maternal diabetesMaternal diabetesRegulator of mitochondrial biogenesisTranscription factor AImpaired mitochondrial biogenesisMitochondria transcription factor ABiogenesis pathwayMetabolic diseasesMtDNAFetal sex-specific differencesCopy numberTFAM levelsGene expressionMale offspringBiogenesisAbnormal placental functionTFAMNon-diabetic womenOffspring sexIndex of mitochondrial biogenesis
2011
Partial Exchange Transfusion for Polycythemia Hyperviscosity Syndrome
Hopewell B, Steiner L, Ehrenkranz R, Bizzarro M, Gallagher P. Partial Exchange Transfusion for Polycythemia Hyperviscosity Syndrome. American Journal Of Perinatology 2011, 28: 557-564. PMID: 21365533, DOI: 10.1055/s-0031-1274504.Peer-Reviewed Original ResearchConceptsPartial exchange transfusionPercent of patientsRisk factorsMaternal diabetesExchange transfusionSignificant complicationsHyperviscosity syndromeNeonatal intensive care unitYale-New Haven HospitalLife-threatening complicationsLong-term followIntensive care unitNeonatal medical recordsPatient demographicsRetrospective reviewCare unitMedical recordsRisk populationsComplicationsPatientsStudy periodSignificant decreaseTransfusionDiabetesSyndrome
2006
Is severe perineal damage increased in women with prior anal sphincter injury?
Edwards H, Grotegut C, Harmanli O, Rapkin D, Dandolu V. Is severe perineal damage increased in women with prior anal sphincter injury? The Journal Of Maternal-Fetal & Neonatal Medicine 2006, 19: 723-727. PMID: 17127495, DOI: 10.1080/14767050600921307.Peer-Reviewed Original ResearchConceptsAnal sphincter lacerationObstetric anal sphincter lacerationGroup of patientsSphincter lacerationTemple University HospitalChart reviewVaginal deliveryUniversity HospitalSubsequent deliverySevere perineal damageAnal sphincter injuryRetrospective chart reviewOperative vaginal deliveryRate of recurrenceRisk of recurrenceUse of episiotomyAugmentation of laborMedical record databaseThird-degree lacerationsInitial lacerationSphincter injuryDegree lacerationsInstrumental deliverySphincter tearsMaternal diabetes
2003
Maternal Diabetes: Effects on Embryonic Vascular Development—A Vascular Endothelial Growth Factor-A-mediated Process
Madri JA, Enciso J, Pinter E. Maternal Diabetes: Effects on Embryonic Vascular Development—A Vascular Endothelial Growth Factor-A-mediated Process. Pediatric And Developmental Pathology 2003, 6: 334-341. PMID: 14692647, DOI: 10.1007/s10024-003-5051-9.Peer-Reviewed Original ResearchConceptsEmbryonic lethal phenotypeGrowth factorVascular endothelial growth factorEndothelial growth factorEpithelial-mesenchymal transformationCardiovascular patterningAberrant organogenesisLethal phenotypeVasculogenesis/angiogenesisPhosphorylation stateTargeted mutationsYolk sacMajor congenital malformationsFactor 1Major birth defectsGrowth factor-1OrganogenesisAdhesion moleculesConceptus culturesMaternal diabetesDiabetic miceCardiovascular abnormalitiesVitelline circulationCongenital malformationsBirth defects
1998
Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats
Jacobs H, Bogue C, Pinter E, Wilson C, Warshaw J, Gross I. Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats. Pediatric Research 1998, 44: 99-104. PMID: 9667378, DOI: 10.1203/00006450-199807000-00016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsButyratesButyric AcidDiabetes Mellitus, ExperimentalEmbryonic and Fetal DevelopmentFemaleGene Expression Regulation, DevelopmentalGenes, HomeoboxGestational AgeHistone Deacetylase InhibitorsLungOrgan Culture TechniquesPregnancyPregnancy in DiabeticsRatsRats, Sprague-DawleyRNA, MessengerTranscription, GeneticConceptsLung developmentLung explantsSurfactant apoproteinExperimental animalsLung mRNA levelsElevated levelsEffect of diabetesFetal rat lung explantsLungs of fetusesRat lung explantsEffect of butyrateAntenatal exposureMaternal diabetesMetabolic abnormalitiesStreptozotocin treatmentLower incidenceNormal ratsDiabetesDexamethasoneLevel of expressionRatsTreatment of explantsSodium butyrateMRNA levelsAlters expression
1994
Butyrate modulates surfactant protein mRNA in fetal rat lung by altering mRNA transcription and stability
Peterec S, Nichols K, Dynia D, Wilson C, Gross I. Butyrate modulates surfactant protein mRNA in fetal rat lung by altering mRNA transcription and stability. American Journal Of Physiology 1994, 267: l9-l15. PMID: 8048547, DOI: 10.1152/ajplung.1994.267.1.l9.Peer-Reviewed Original ResearchConceptsFetal rat lungButyric acid analogueMRNA concentrationsRat lungNa-butyrateSP-A levelsDiabetic pregnanciesMaternal diabetesPulmonary maturationLung maturationMRNA transcriptionBiphasic effectSurfactant protein mRNAsProtein mRNASP-B mRNAAcid analoguesButyrate treatmentLungExposure of explantsFetusesInitial decreaseMRNAGene expressionButyrateMaturation
1986
Congenital heart disease and extracardiac anomalies: Associations and indications for fetal echocardiography
Copel J, Pilu G, Kleinman C. Congenital heart disease and extracardiac anomalies: Associations and indications for fetal echocardiography. American Journal Of Obstetrics And Gynecology 1986, 154: 1121-1132. PMID: 2939723, DOI: 10.1016/0002-9378(86)90773-8.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal MusclesAbnormalities, Drug-InducedAbnormalities, MultipleCentral Nervous SystemChromosome AberrationsChromosome DisordersCongenital AbnormalitiesDigestive System AbnormalitiesEchocardiographyFemaleFetal HeartHeart Defects, CongenitalHumansInfant, NewbornPhenylketonuriasPregnancyPregnancy ComplicationsPregnancy in DiabeticsPrenatal DiagnosisRespiratory System AbnormalitiesUrogenital AbnormalitiesConceptsCongenital heart diseaseHeart diseaseExtracardiac anomaliesFetal echocardiographyCardiac evaluationMaternal diabetesNeonatal managementDiaphragmatic herniaDuodenal atresiaPediatric literatureRenal dysplasiaCorpus callosumDifferential diagnosisEsophageal atresiaMeckel-Gruber syndromeReported associationsEchocardiographyPrenatal identificationSystemic defectsDiseaseAtresiaCoexistent defectsAssociationIndicationsDiabetes
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