2022
Fulminant Viral Hepatitis in Two Siblings with Inherited IL-10RB Deficiency
Korol C, Belkaya S, Alsohime F, Lorenzo L, Boisson-Dupuis S, Brancale J, Neehus A, Vilarinho S, Zobaida A, Halwani R, Al-Muhsen S, Casanova J, Jouanguy E. Fulminant Viral Hepatitis in Two Siblings with Inherited IL-10RB Deficiency. Journal Of Clinical Immunology 2022, 43: 406-420. PMID: 36308662, PMCID: PMC9892130, DOI: 10.1007/s10875-022-01376-5.Peer-Reviewed Original ResearchConceptsEarly onset inflammatory bowel diseaseFulminant viral hepatitisHepatitis A virusIL-10IL-22IL-26Viral hepatitisIFN-λ1Inflammatory bowel diseaseIFN-γ productionIFN-γ activityLife-threatening diseaseImpairs cellular responsesHAV infectionBowel diseaseLymphocyte cytotoxicityIL-18BPIFN-λsDisease-causing variantsHealthy individualsPatientsA virusCellular responsesUnrelated patientsPotent antagonist
2018
DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation
Xiao Q, Wu J, Wang WJ, Chen S, Zheng Y, Yu X, Meeth K, Sahraei M, Bothwell ALM, Chen L, Bosenberg M, Chen J, Sexl V, Sun L, Li L, Tang W, Wu D. DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation. Nature Medicine 2018, 24: 262-270. PMID: 29431745, PMCID: PMC5840007, DOI: 10.1038/nm.4496.Peer-Reviewed Original ResearchMeSH KeywordsAdenomatous Polyposis Coli Proteinbeta CateninCD8-Positive T-LymphocytesCell Line, TumorColorectal NeoplasmsCytotoxicity, ImmunologicGene Expression Regulation, NeoplasticHumansIntercellular Signaling Peptides and ProteinsIntestinal NeoplasmsKiller Cells, NaturalLow Density Lipoprotein Receptor-Related Protein-5MelanomaProgrammed Cell Death 1 ReceptorPTEN PhosphohydrolaseSignal TransductionSTAT5 Transcription FactorTumor EscapeConceptsImmune cell activationLymphocyte cytotoxicityImmune evasionTumor cellsImmunity evasionWnt pathwayNegative regulatorEvasion
2013
The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2
Jessen B, Bode S, Ammann S, Chakravorty S, Davies G, Diestelhorst J, Frei-Jones M, Gahl W, Gochuico B, Griese M, Griffiths G, Janka G, Klein C, Kögl T, Kurnik K, Lehmberg K, Maul-Pavicic A, Mumford A, Pace D, Parvaneh N, Rezaei N, de Saint Basile G, Schmitt-Graeff A, Schwarz K, Karasu G, Zieger B, Stadt U, Aichele P, Ehl S. The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2. Blood 2013, 121: 2943-2951. PMID: 23403622, PMCID: PMC3624940, DOI: 10.1182/blood-2012-10-463166.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Protein Complex 3Adaptor Protein Complex beta SubunitsAdolescentAdultAnimalsChildChild, PreschoolCytotoxicity, ImmunologicFlow CytometryHermanski-Pudlak SyndromeHumansLymphohistiocytosis, HemophagocyticMiceMice, Inbred C57BLMice, KnockoutMutationrab GTP-Binding Proteinsrab27 GTP-Binding ProteinsRisk FactorsT-Lymphocytes, CytotoxicYoung AdultConceptsHermansky-Pudlak syndrome type 2Hemophagocytic lymphohistiocytosisLymphocyte cytotoxicityHPS2 patientsRAB27A mutationsPatients to hemophagocytic lymphohistiocytosisRisk of hemophagocytic lymphohistiocytosisFeatures of hemophagocytic lymphohistiocytosisHematopoietic stem cell transplantationHermansky-PudlakImpaired virus controlPerforin-deficient miceStem cell transplantationType 2Lymphocytic choriomeningitis virusCytotoxicity in vivoChediak-Higashi syndromeCytotoxicity defectsCell transplantationPatient yearsPearl micePatientsGenetic disordersMilder defectsDisease parameters
2012
Syntaxin 11 is required for NK and CD8+ T‐cell cytotoxicity and neutrophil degranulation
D'Orlando O, Zhao F, Kasper B, Orinska Z, Müller J, Hermans‐Borgmeyer I, Griffiths G, Stadt U, Bulfone‐Paus S. Syntaxin 11 is required for NK and CD8+ T‐cell cytotoxicity and neutrophil degranulation. European Journal Of Immunology 2012, 43: 194-208. PMID: 23042080, PMCID: PMC5405866, DOI: 10.1002/eji.201142343.Peer-Reviewed Original ResearchConceptsVesicular traffickingSyntaxin-11NK cellsLymphocyte cytotoxicityT cellsIFN-gActivated CD8(+) T cellsCD8+ T cell cytotoxicityCD8(+) T cellsLevels of IFN-gT cell cytotoxicityImmune cell populationsMacrophage phagocytic functionMast cell activationDefective phenotypesImmune cellsSTX11 mutationsAntigen presentationCytokine productionCytokine secretionImpaired degranulationSTX11Cell activationPhagocytic functionFunctional reconstitution
1993
The Granzyme A Gene: A Marker for Cytolytic Lymphocytes In Vivo
Griffiths G, Alpert S, Hershberger R, Su L, Weissman I. The Granzyme A Gene: A Marker for Cytolytic Lymphocytes In Vivo. 1993, 273-277. DOI: 10.1007/978-1-4684-6814-4_25.Peer-Reviewed Original Research
1980
Successful kidney transplantation despite T lymphocyte cytotoxicity: Role of donor specific blood transfusion
Schweizer R, Bow L, Hosey D, Bartus S. Successful kidney transplantation despite T lymphocyte cytotoxicity: Role of donor specific blood transfusion. Human Immunology 1980, 1: 283-284. DOI: 10.1016/0198-8859(80)90078-6.Peer-Reviewed Original Research
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