Chaotic activation of developmental signalling pathways drives idiopathic pulmonary fibrosis
Froidure A, Marchal-Duval E, Homps-Legrand M, Ghanem M, Justet A, Crestani B, Mailleux A. Chaotic activation of developmental signalling pathways drives idiopathic pulmonary fibrosis. European Respiratory Review 2020, 29: 190140. PMID: 33208483, PMCID: PMC9488512, DOI: 10.1183/16000617.0140-2019.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisActivation of developmental pathwaysChronically injured lungTransforming growth factor-bChronic lung injuryStem cell therapyType 2 cell hyperplasiaSonic hedgehog pathwayRemodelling of lung parenchymaGrowth factor BIdiopathic pulmonary fibrosis fibroblastsRegulation of cell transformationLung repairLung injuryCell therapyExpression of pathwaysActivation of developmental signaling pathwaysLung architectureLung parenchymaDevelopmental signaling pathwaysTranscriptional integrityHedgehog pathwayFibrosisLung
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