2022
CD38 Mediates Lung Fibrosis by Promoting Alveolar Epithelial Cell Aging.
Cui H, Xie N, Banerjee S, Dey T, Liu RM, Antony VB, Sanders YY, Adams TS, Gomez JL, Thannickal VJ, Kaminski N, Liu G. CD38 Mediates Lung Fibrosis by Promoting Alveolar Epithelial Cell Aging. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 459-475. PMID: 35687485, PMCID: PMC12039157, DOI: 10.1164/rccm.202109-2151oc.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisLung fibrosisCD38 expressionAlveolar epithelial cell injuryEpithelial cell injuryEffective therapeutic strategyHuman lung parenchymaIPF lungsLung functionPulmonary fibrosisDisease progressionFibrotic lungsReal-time PCRYoung miceLung parenchymaOld miceCell injuryTherapeutic strategiesFibrosisPharmacological inactivationCD38Single-cell RNA sequencingFlow cytometryWestern blottingOld animalsPhenotypes of Motor Deficit and Pain after Experimental Spinal Cord Injury
Krotov V, Medvediev V, Abdallah I, Bozhenko A, Tatarchuk M, Ishchenko Y, Pichkur L, Savosko S, Tsymbaliuk V, Kopach O, Voitenko N. Phenotypes of Motor Deficit and Pain after Experimental Spinal Cord Injury. Bioengineering 2022, 9: 262. PMID: 35735505, PMCID: PMC9220047, DOI: 10.3390/bioengineering9060262.Peer-Reviewed Original ResearchSpinal cord injuryMotor deficitsMotor dysfunctionSCI ratsCord injuryNociceptive sensitivityExperimental spinal cord injuryModerate spinal cord injuryLong-term rehabilitationPain syndromeSevere complicationsMotor functionIdentical injuryPainInjuryMotor disabilityDysfunctionNeurotraumaOld animalsMechanical modalitiesTissue capabilityCommon outcomeRegression analysisDeficitsRats
2017
The aged rhesus macaque manifests Braak stage III/IV Alzheimer's‐like pathology
Paspalas CD, Carlyle BC, Leslie S, Preuss TM, Crimins JL, Huttner AJ, van Dyck C, Rosene DL, Nairn AC, Arnsten AFT. The aged rhesus macaque manifests Braak stage III/IV Alzheimer's‐like pathology. Alzheimer's & Dementia 2017, 14: 680-691. PMID: 29241829, PMCID: PMC6178089, DOI: 10.1016/j.jalz.2017.11.005.Peer-Reviewed Original ResearchConceptsLate-onset Alzheimer's diseaseCortical pathologyEntorhinal cortexAnimal modelsBraak stage III/IVAlzheimer's diseaseStage III/IVRhesus macaquesProgression of tauAlzheimer-like pathologyPrimary visual cortexSequence of tauDorsolateral prefrontal cortexTau pathologyPreventive strategiesAssociation cortexVisual cortexPrefrontal cortexCortexPathologyDiseaseOld animalsProtein kinase A (PKA) phosphorylationGenetic insultsMacaques
2011
Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition
Condello C, Schain A, Grutzendler J. Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition. Scientific Reports 2011, 1: 19. PMID: 22355538, PMCID: PMC3216507, DOI: 10.1038/srep00019.Peer-Reviewed Original ResearchConceptsPlaque burdenAmyloid depositionAlzheimer's diseaseAD mouse modelPlaque enlargementClinicopathological studyNeuritic dystrophyPathogenic rolePostmortem studiesAmyloid plaquesNew plaquesConsequent neurotoxicityMouse modelOld plaquesQuantitative confocal imagingCognitive statusPlaquesPlaque expansionOld animalsAmyloid-binding dyesNeurotoxicityDiseasePoor correlationBurdenCritical determinant
2006
Orexin neuronal changes in the locus coeruleus of the aging rhesus macaque
Downs JL, Dunn MR, Borok E, Shanabrough M, Horvath TL, Kohama SG, Urbanski HF. Orexin neuronal changes in the locus coeruleus of the aging rhesus macaque. Neurobiology Of Aging 2006, 28: 1286-1295. PMID: 16870307, DOI: 10.1016/j.neurobiolaging.2006.05.025.Peer-Reviewed Original ResearchConceptsLateral hypothalamic areaPoor sleep qualityLocus coeruleusNoradrenergic locus coeruleusSleep qualityNeuron numberRhesus macaquesAge-related decreaseTyrosine hydroxylase mRNAAge-related lossMale rhesus macaquesOrexin innervationOrexin neuronsOrexin neuropeptidesAge-related declineB immunoreactivityHypothalamic areaNeuronal changesElderly humansAxon densityLC contributeHydroxylase mRNANonhuman primatesOld animalsAdult animals
2004
Age‐associated synapse elimination in mouse parasympathetic ganglia
Coggan JS, Grutzendler J, Bishop DL, Cook MR, Gan W, Heym J, Lichtman JW. Age‐associated synapse elimination in mouse parasympathetic ganglia. Developmental Neurobiology 2004, 60: 214-226. PMID: 15266652, DOI: 10.1002/neu.20022.Peer-Reviewed Original ResearchConceptsSynapse eliminationExcitatory postsynaptic potential amplitudeSubmandibular ganglion neuronsPostsynaptic potential amplitudeNumber of synapsesMonths of ageMammalian nervous systemAge-related changesMiniature EPSPsSMG neuronsSynapse efficacyParasympathetic gangliaGanglion neuronsEPSP amplitudeSynaptic contactsSynaptic transmissionSynaptic inputsAged animalsPotential amplitudeNervous systemSynaptic boutonsAxonal processesNeuronsOld animalsPostsynaptic membrane
1999
Insulin resistance and glucose transporter expression during the euglycemic hyperinsulinemic clamp in the lamb
Gelardi N, Rapoza R, Renzulli J, Cowett R. Insulin resistance and glucose transporter expression during the euglycemic hyperinsulinemic clamp in the lamb. American Journal Of Physiology 1999, 277: e1142-e1149. PMID: 10600805, DOI: 10.1152/ajpendo.1999.277.6.e1142.Peer-Reviewed Original ResearchConceptsEuglycemic hyperinsulinemic clampHyperinsulinemic clampAge-matched lambsYoung animalsEndogenous glucose productionInsulin-resistant statesGLUT-4 protein expressionEffect of insulinGLUT-2 expressionGLUT-4 expressionGlucose transporter expressionInsulin resistanceGreater glucose utilizationAcute changesMU xGlucose utilizationGlucose productionYounger groupOlder groupTransporter expressionOld animalsProtein expressionInsulinPercent decrease
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