2023
Methods for mediation analysis with high-dimensional DNA methylation data: Possible choices and comparisons
Clark-Boucher D, Zhou X, Du J, Liu Y, Needham B, Smith J, Mukherjee B. Methods for mediation analysis with high-dimensional DNA methylation data: Possible choices and comparisons. PLOS Genetics 2023, 19: e1011022. PMID: 37934796, PMCID: PMC10655967, DOI: 10.1371/journal.pgen.1011022.Peer-Reviewed Original ResearchConceptsBayesian Sparse Linear Mixed ModelMediation analysisHigh-dimensional mediation analysisMulti-ethnic cohortEpigenetic researchHealth outcomesHigh-dimensional DNA methylation dataLinear mixed modelsDNA methylation dataContinuous outcomesEvaluate DNA methylationDNA methylationMethylation dataDNAm dataMixed modelsDiverse simulationsSeamless implementationModern statistical methodsMediation effectR packageUnited StatesOutcomesThe Promise of Epigenetics Research in the Treatment of Appendiceal Neoplasms
Ladel L, Tan W, Jeyakanthan T, Sailo B, Sharma A, Ahuja N. The Promise of Epigenetics Research in the Treatment of Appendiceal Neoplasms. Cells 2023, 12: 1962. PMID: 37566041, PMCID: PMC10417136, DOI: 10.3390/cells12151962.Peer-Reviewed Original ResearchA systematic review of neuroimaging epigenetic research: calling for an increased focus on development
Walton E, Baltramonaityte V, Calhoun V, Heijmans B, Thompson P, Cecil C. A systematic review of neuroimaging epigenetic research: calling for an increased focus on development. Molecular Psychiatry 2023, 28: 2839-2847. PMID: 37185958, PMCID: PMC10615743, DOI: 10.1038/s41380-023-02067-2.Peer-Reviewed Original ResearchConceptsFunctional neuroimaging measuresBrain-based disordersBrain imaging measuresBrain alterationsNeuroimaging measuresBrain outcomesInvestigate environmental influencesBehavioral outcomesDevelopmental periodEnvironmental influencesSample characteristicsDNA methylationSystematically review evidenceBrainTime of lifeDisordersMeasurement of DNA methylationContext of healthImaging measurementsCandidate-gene approachEpigenetic mechanismsEpigenetic researchMeta-analysisDNA methylation markersYears of age
2011
Evolving Genomic Approaches to Idiopathic Pulmonary Fibrosis: Moving Beyond Genes
Kass DJ, Kaminski N. Evolving Genomic Approaches to Idiopathic Pulmonary Fibrosis: Moving Beyond Genes. Clinical And Translational Science 2011, 4: 372-379. PMID: 22029812, PMCID: PMC3229869, DOI: 10.1111/j.1752-8062.2011.00287.x.Peer-Reviewed Original ResearchConceptsGenomic technologiesIdiopathic pulmonary fibrosisPathogenesis of diseaseGenomic discoveriesSystems biology approachGene expression profilingContribution of microRNAsMost human diseasesGenomic approachesGene networksBiology approachHuman genomeEpigenetic researchGenomic dataExpression profilingHuman diseasesPulmonary fibrosisDiagnosis of IPFGenesLarge collaborative studiesProgressive scarringPeripheral bloodClinical severityLung parenchymaTherapeutic goals
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