2025
Induction of immune tolerance in living related human leukocyte antigen–matched kidney transplantation: A phase 3 randomized clinical trial
Kaufman D, Akkina S, Stegall M, Piper J, Gaber A, Asch W, Busque S, Stites E, De Vera M, Srinivas T, Alonso D, Shah A, Patel A, L. M, Chavin K, DebRoy M, Jittirat A, Costa N, Cooper M, Vranic G, Laftavi M, Saidi R, Collette S, Brennan D, Group M. Induction of immune tolerance in living related human leukocyte antigen–matched kidney transplantation: A phase 3 randomized clinical trial. American Journal Of Transplantation 2025, 25: 1461-1470. PMID: 39922283, DOI: 10.1016/j.ajt.2025.01.044.Peer-Reviewed Original ResearchRecurrent immunoglobulin A nephropathyKidney transplant recipientsImmunoglobulin A nephropathyImmune toleranceStandard of careMixed chimerismHost diseaseTransplant recipientsKidney transplantationClinical trialsPhase 3 randomized clinical trialInduction of immune toleranceInstitutional standard of careDonor mixed chimerismFunctional immune toleranceHematopoietic mixed chimerismNonmyeloablative conditioning protocolTotal lymphoid irradiationRabbit antithymocyte globulinPrimary study endpointHLA-matched kidney transplantsRecipients of kidneysPhase 3 multicenterControlled clinical trialsLymphoid irradiation
2008
Stable Long-Term Donor Engraftment following Reduced-Intensity Hematopoietic Cell Transplantation for Sickle Cell Disease
Krishnamurti L, Kharbanda S, Biernacki M, Zhang W, Baker K, Wagner J, Wu C. Stable Long-Term Donor Engraftment following Reduced-Intensity Hematopoietic Cell Transplantation for Sickle Cell Disease. Transplantation And Cellular Therapy 2008, 14: 1270-1278. PMID: 18940682, DOI: 10.1016/j.bbmt.2008.08.016.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnemia, Sickle CellChildCyclosporineFemaleGraft SurvivalGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansImmunosuppressive AgentsLiving DonorsMaleMycophenolic AcidMyeloablative AgonistsSiblingsTransplantation ChimeraTransplantation ConditioningTransplantation, HomologousConceptsHematopoietic stem cell transplantationSickle cell diseaseRIC regimenCell transplantationCell diseaseEfficacy of HSCTHigh-risk sickle cell diseaseReduced-Intensity Hematopoietic Cell TransplantationAllogeneic hematopoietic stem cell transplantationReduced-intensity conditioning regimensEquine antithymocyte globulinHost disease (GVHD) prophylaxisTotal lymphoid irradiationAcceptable therapeutic optionHematopoietic cell transplantationGroup of patientsStem cell transplantationAntithymocyte globulinLymphoid irradiationConditioning regimenMycophenolate mofetilConditioning regimensDisease prophylaxisDonor engraftmentTherapeutic options
2003
Coronary atherosclerosis in cardiac transplant patients treated with total lymphoid irradiation
Pelletier M, Coady M, Macha M, Oyer P, Robbins R. Coronary atherosclerosis in cardiac transplant patients treated with total lymphoid irradiation. The Journal Of Heart And Lung Transplantation 2003, 22: 124-129. PMID: 12581759, DOI: 10.1016/s1053-2498(02)00493-x.Peer-Reviewed Original ResearchConceptsTotal lymphoid irradiationLymphoid irradiationAllograft rejectionPatients treated with total lymphoid irradiationIncreased incidence of coronary atherosclerosisMultiple episodes of rejectionCoronary atherosclerosisRecurrent allograft rejectionEpisodes of rejectionCoronary artery diseaseIncidence of coronary atherosclerosisCardiac transplantationHeart transplantationCoronary angiogramArtery diseaseIncreased incidenceControl groupMultiple episodesTransplantationPatientsAtherosclerosisRejectionAngiogram
1997
Modified total lymphoid irradiation and low dose corticosteroids in progressive multiple sclerosis
Cook S, Devereux C, Troiano R, Wolansky L, Guarnaccia J, Haffty B, Bansil S, Goldstein J, Sheffet A, Zito G, Jotkowitz A, Boos J, Dowling P, Rohowsky-Kochan C, Volmer T. Modified total lymphoid irradiation and low dose corticosteroids in progressive multiple sclerosis. Journal Of The Neurological Sciences 1997, 152: 172-181. PMID: 9415539, DOI: 10.1016/s0022-510x(97)00189-5.Peer-Reviewed Original ResearchConceptsTotal lymphoid irradiationMultiple sclerosisLymphoid irradiationDuration of MSExpanded Disability Status ScaleProgressive formKaplan-Meier product-limit survival analysisLow-dose corticosteroidsLow-dose prednisoneProgressive multiple sclerosisPrimary study endpointDisability Status ScaleProduct-limit survival analysisDose corticosteroidsDose prednisoneIntravenous methylprednisolonePrednisone therapyTLI groupTLI patientsSystemic immunosuppressionPatient ageStudy endpointStudy entrySham groupStatus Scale
1993
Phenotypic and Functional Analysis of Expanded Natural Killer Cell Subpopulations in Hodgkin’s Disease Patients Treated with Lymphoid Irradiation
Macklis R, Mauch P, Thompson L, Burakoff S, Smith B. Phenotypic and Functional Analysis of Expanded Natural Killer Cell Subpopulations in Hodgkin’s Disease Patients Treated with Lymphoid Irradiation. Oncology 1993, 50: 323-328. PMID: 8497384, DOI: 10.1159/000227203.Peer-Reviewed Original ResearchConceptsNK cell subsetsNK cell compartmentHodgkin's disease patientsDisease patientsLymphoid irradiationNK cellsCell subsetsNatural killer cell subpopulationsSpecific NK cell subsetsLong-term immunosuppressionNK cell assaysCell compartmentSignificant changesCell subpopulationsPatientsCytometric cell sortingLytic activityCell assayImmunophenotypeCell sortingCytotoxicity spectrumImmunosuppressionCellsSubsetCompartments
1989
MS: a CNS and systematic autoimmune disease
Hafler D, Weiner H. MS: a CNS and systematic autoimmune disease. Trends In Immunology 1989, 10: 104-107. PMID: 2472810, DOI: 10.1016/0167-5699(89)90236-3.Peer-Reviewed Original ResearchConceptsPeripheral immune compartmentCentral nervous systemImmune compartmentMultiple sclerosisImmunoregulatory defectsMS patientsAutoimmune diseasesCNS inflammatory responsesTotal lymphoid irradiationProgressive multiple sclerosisT-cell abnormalitiesB cell hyperactivitySystemic lupus erythematosusT cell functionSystematic autoimmune diseaseActivated T cellsLymphoid irradiationDisease activityImmune abnormalitiesSystemic treatmentLupus erythematosusRheumatoid arthritisPeripheral bloodInflammatory diseasesInflammatory response
1987
Suppressor cells induced by total lymphoid irradiation affect proliferation and lymphokine production of murine T helper cell clones
Mate T, Ruddle N. Suppressor cells induced by total lymphoid irradiation affect proliferation and lymphokine production of murine T helper cell clones. International Journal Of Radiation Oncology • Biology • Physics 1987, 13: 61-68. PMID: 2948938, DOI: 10.1016/0360-3016(87)90261-6.Peer-Reviewed Original ResearchConceptsTotal lymphoid irradiationT helper cell clonesSuppressor cellsInterleukin-2Lymphoid irradiationT-helper cell proliferative responsesCell clonesT cell capacityT cell growth factorHelper T cellsT cell populationsCell proliferative responsesMarked inhibitory effectGamma-IFN releaseLympho-reticular tissuesCell growth factorMurine T helper cell clonesNodal irradiationType hypersensitivityAntigen responseImmune suppressionImmunosuppressive effectsLymphokine responsesAntigen presentationT cells
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