2020
PD-L1 Expression in Anal Intraepithelial Neoplasia Versus. Invasive Squamous Cell Carcinoma
Monsrud A, Avadhani V, Mosunjac M, Krishnamurti U. PD-L1 Expression in Anal Intraepithelial Neoplasia Versus. Invasive Squamous Cell Carcinoma. American Journal Of Clinical Pathology 2020, 154: s67-s67. DOI: 10.1093/ajcp/aqaa161.146.Peer-Reviewed Original ResearchInvasive squamous cell carcinomaPD-L1 positivityPD-L1 expressionCases of ISCCSquamous cell carcinomaTumor proportion scoreSquamous intraepithelial lesionsPD-L1Normal mucosaIntraepithelial lesionsCell carcinomaGranular cytoplasmic stainingInvasive carcinomaProportion scoreLow-grade squamous intraepithelial lesionsCytoplasmic stainingPD-L1 positive casesAnal squamous intraepithelial lesionsHigh-grade intraepithelial lesionsGrade squamous intraepithelial lesionNuclear stainingAnal intraepithelial neoplasiaPD-L1 inhibitorsAberrant nuclear stainingAIN 2
2018
Biomarker P16 predicts progression risk of anal low-grade squamous intraepithelial lesions
Liu Y, Blakely M, Sigel K, Thin TH, Hui P, Donovan M, Gaisa MM. Biomarker P16 predicts progression risk of anal low-grade squamous intraepithelial lesions. AIDS 2018, 32: 2309-2316. PMID: 30005024, PMCID: PMC6862769, DOI: 10.1097/qad.0000000000001957.Peer-Reviewed Original ResearchConceptsLow-grade squamous intraepithelial lesionsAnal low-grade squamous intraepithelial lesionsSquamous intraepithelial lesionsHigh-grade squamous intraepithelial lesionsBiomarker p16Intraepithelial lesionsIndex lesionP16 immunohistochemistryProgression riskHigh-risk human papillomavirus DNACD4 T-cell countFormer smoker statusHistory of condylomaT-cell countsHR-HPV DNAYear of diagnosisHuman papillomavirus DNASemi-quantitative scoring systemAssociation of predictorsLogistic regression modelsOnly significant predictorOrdinal logistic regression modelsClinical outcomesUnderwent surveillanceRetrospective study
2015
Cytology as a screening tool for anal squamous intraepithelial lesion for HIV positive men: 10-year experience in an inner city hospital
Johnson G, Nguyen M, Krishnamurti U, Seydafkan S, Flowers L, Ehdaivand S, Mosunjac M. Cytology as a screening tool for anal squamous intraepithelial lesion for HIV positive men: 10-year experience in an inner city hospital. Journal Of The American Society Of Cytopathology 2015, 5: 145-153. PMID: 31042517, DOI: 10.1016/j.jasc.2015.08.003.Peer-Reviewed Original ResearchLow-grade squamous intraepithelial lesionsSquamous intraepithelial lesionsHigh-risk patientsAnal cytologyIntraepithelial lesionsInner-city hospitalHuman papillomavirusAnal intraepithelial neoplasia grade 2High-grade squamous intraepithelial lesionsAnal squamous intraepithelial lesionsAnal cytology specimensPercent of patientsAtypical squamous cellsHIV-positive menHuman immunodeficiency virusHigh-risk populationASC-US casesMethod of biopsyDegree of dysplasiaPositive predictive valueCytology-histology correlationRate of detectionClear guidelinesHPV testingAnal carcinomaGrading of atypia in genital skin lesions: routine microscopic evaluation and use of p16 immunostaining
Ezaldein H, Lott JP, McNiff JM, Hui P, Buza N, Ko CJ. Grading of atypia in genital skin lesions: routine microscopic evaluation and use of p16 immunostaining. Journal Of Cutaneous Pathology 2015, 42: 519-526. PMID: 25951050, DOI: 10.1111/cup.12525.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorCross-Sectional StudiesCyclin-Dependent Kinase Inhibitor p16FemaleGenitalia, FemaleHumansImmunohistochemistryMaleMiddle AgedNeoplasm ProteinsObserver VariationPapillomavirus InfectionsSensitivity and SpecificitySkin DiseasesSquamous Intraepithelial Lesions of the CervixUterine Cervical NeoplasmsConceptsGenital skin lesionsHigh-grade squamous intraepithelial lesionsLow-grade squamous intraepithelial lesionsSquamous intraepithelial lesionsP16 immunostainingSkin lesionsDiagnostic agreementIntraepithelial lesionsUseful adjunctive markerHigh-grade dysplasiaCross-sectional studyRoutine microscopic evaluationDegree of atypiaAdjunctive markerInter-observer agreementPrimary outcomeCervical lesionsHistopathologic assessmentHistopathologic evaluationConsensus diagnosisReactive atypiaEosin stainingOriginal diagnosisAtypiaLesionsPrevalence of Human Papillomavirus Genotypes among African Women with Normal Cervical Cytology and Neoplasia: A Systematic Review and Meta-Analysis
Ogembo RK, Gona PN, Seymour AJ, Park HS, Bain PA, Maranda L, Ogembo JG. Prevalence of Human Papillomavirus Genotypes among African Women with Normal Cervical Cytology and Neoplasia: A Systematic Review and Meta-Analysis. PLOS ONE 2015, 10: e0122488. PMID: 25875167, PMCID: PMC4396854, DOI: 10.1371/journal.pone.0122488.Peer-Reviewed Original ResearchConceptsHigh-grade squamous intraepithelial lesionsLow-grade squamous intraepithelial lesionsInvasive cervical carcinomaNormal cervical cytologySquamous intraepithelial lesionsHuman papillomavirusIntraepithelial lesionsCervical cytologyOverall prevalenceMeta-analysisSystematic reviewHPV type-specific prevalenceAfrican womenCervical neoplastic diseaseHPV genotype prevalencePrevalent human papillomavirusesType-specific prevalenceAtypical squamous cellsCervical cancer morbidityCervical cancer casesHuman papillomavirus genotypesHigh-risk genotypesInternational Prospective RegisterMeta-Analyses (PRISMA) guidelinesPreferred Reporting Items
2011
Use of high‐risk human papillomavirus testing in patients with low‐grade squamous intraepithelial lesions
Levi AW, Harigopal M, Hui P, Schofield K, Chhieng DC. Use of high‐risk human papillomavirus testing in patients with low‐grade squamous intraepithelial lesions. Cancer Cytopathology 2011, 119: 228-234. PMID: 21732551, DOI: 10.1002/cncy.20172.Peer-Reviewed Original ResearchConceptsLow-grade squamous intraepithelial lesionsHR-HPV testingHPV testingCIN 2Colposcopy rateHR-HPVRelative light units/cutoffCervical intraepithelial neoplasia 2High-risk human papillomavirusHR-HPV statusRLU/COIntraepithelial neoplasia 2Hybrid Capture 2Squamous intraepithelial lesionsCIN 1 lesionsLarge teaching hospitalNegative predictive valueLSIL cytologyHPV statusIntraepithelial lesionsCapture 2Human papillomavirusTeaching hospitalCytologic diagnosisSevere lesions
2009
Anal squamous intraepithelial lesions among HIV positive and HIV negative men who have sex with men in Thailand
Li AH, Phanuphak N, Sahasrabuddhe VV, Chaithongwongwatthana S, Vermund SH, Jenkins CA, Shepherd BE, Teeratakulpisarn N, van der Lugt J, Avihingsanon A, Ruxrungtham K, Shikuma C, Phanuphak P, Ananworanich J. Anal squamous intraepithelial lesions among HIV positive and HIV negative men who have sex with men in Thailand. Sexually Transmitted Infections 2009, 85: 503. PMID: 19525263, PMCID: PMC3875384, DOI: 10.1136/sti.2009.036707.Peer-Reviewed Original ResearchConceptsAnal squamous intraepithelial lesionsHigh-grade squamous intraepithelial lesionsLow-grade squamous intraepithelial lesionsHIV-negative MSMSquamous intraepithelial lesionsHIV-positive MSMNegative MSMHIV-negative menIntraepithelial lesionsPositive MSMRisk factorsAnal condylomaNegative menActive antiretroviral therapy (HAART) useAbnormal anal cytologyAnal cancer precursorsAnal Pap smearsAnal precancerous lesionsAntiretroviral therapy useT-cell countsAtypical squamous cellsSignificant risk factorsAnal cytologyAsian HIVTherapy use
2006
Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia
Parham GP, Sahasrabuddhe VV, Mwanahamuntu MH, Shepherd BE, Hicks ML, Stringer EM, Vermund SH. Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia. Gynecologic Oncology 2006, 103: 1017-1022. PMID: 16875716, PMCID: PMC2748907, DOI: 10.1016/j.ygyno.2006.06.015.Peer-Reviewed Original ResearchConceptsHigh-risk HPV typesSquamous intraepithelial lesionsSquamous cell carcinomaHPV typesIntraepithelial lesionsHIV/AIDS care servicesPrevalence of SILHigh-grade squamous intraepithelial lesionsLow-grade squamous intraepithelial lesionsCervical squamous intraepithelial lesionsMultivariable logistic regression modelingNon-pregnant HIVScreening of HIVDevelopment of HPVLogistic regression modelingResource-constrained settingsResource-constrained nationsMedian CD4Abnormal cytologyAntiretroviral therapyCytological lesionsHPV typingIndependent predictorsMedian ageCervical cancer
2003
Atypical squamous cells of undetermined significance in liquid‐based cytologic specimens
Levi AW, Kelly DP, Rosenthal DL, Ronnett BM. Atypical squamous cells of undetermined significance in liquid‐based cytologic specimens. Cancer 2003, 99: 191-197. PMID: 12925979, DOI: 10.1002/cncr.11507.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overColposcopyCost-Benefit AnalysisDNA, ViralFemaleFollow-Up StudiesHumansMiddle AgedModels, StatisticalPapanicolaou TestPapillomaviridaePapillomavirus InfectionsPatient Care PlanningPolymerase Chain ReactionPractice Guidelines as TopicSensitivity and SpecificityTumor Virus InfectionsUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsConceptsLow-grade squamous intraepithelial lesionsSquamous intraepithelial lesionsHigh-grade squamous intraepithelial lesionsAtypical squamous cellsHPV test resultsHigh-grade lesionsASCUS smearsHPV-positive smearsIntraepithelial lesionsSquamous cellsUndetermined significanceHuman papillomavirus (HPV) DNA testingASCUS interpretationHigh-risk HPV typesHPV-positive casesHPV DNA testingHigh-risk typesLiquid-based Pap smearsLow-grade lesionsDNA testingColposcopy triageHPV testingASCUS cytologyHPV typesPap smear
1999
Risk factors for cervical squamous intraepithelial lesions among HIV‐1 seropositive women in Dar es Salaam, Tanzania
Kapiga SH, Msamanga GI, Spiegelman D, Mwakyoma H, Fawzi WW, Hunter DJ. Risk factors for cervical squamous intraepithelial lesions among HIV‐1 seropositive women in Dar es Salaam, Tanzania. International Journal Of Gynecology & Obstetrics 1999, 67: 87-94. PMID: 10636052, DOI: 10.1016/s0020-7292(99)00125-3.Peer-Reviewed Original ResearchConceptsSquamous intraepithelial lesionsCervical squamous intraepithelial lesionsRisk factorsIntraepithelial lesionsPrevalence of SILRisk of SILHigh-grade squamous intraepithelial lesionsLow-grade squamous intraepithelial lesionsHIV-1-seropositive womenMid-upper arm circumferenceNon-significant increased riskFederation of GynecologyDar es SalaamLifetime sexual partnersLymphocyte subsetsSeropositive womenIncreased riskArm circumferenceCervical smearsLive birthsCell countSexual partnersHIVWomenSexual behavior
1996
Atypical reparative change on cervical/vaginal smears may be associated with dysplasia
Rimm D, Gmitro S, Frable W. Atypical reparative change on cervical/vaginal smears may be associated with dysplasia. Diagnostic Cytopathology 1996, 14: 374-379. PMID: 8725141, DOI: 10.1002/(sici)1097-0339(199605)14:4<374::aid-dc17>3.0.co;2-h.Peer-Reviewed Original ResearchConceptsHigh-grade squamous intraepithelial lesionsLow-grade squamous intraepithelial lesionsAtypical reparative changesDiagnosis of ASCUSSquamous intraepithelial lesionsReparative changesIntraepithelial lesionsAtypical repairVaginal smearsSignificant histologic abnormalitiesUniversity Pathology DepartmentAtypical squamous cellsPercentage of casesChronic cervicitisSquamous cellsSquamous metaplasiaHistologic abnormalitiesHistologic findingsClinical managementHistologic changesCytologic diagnosisBethesda SystemClinical concernPathology departmentMedical College
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