2023
Patient experiences with tissue‐based genomic testing during active surveillance for prostate cancer
Leapman M, Sutherland R, Gross C, Ma X, Seibert T, Cooperberg M, Catalona W, Loeb S, Schulman‐Green D. Patient experiences with tissue‐based genomic testing during active surveillance for prostate cancer. BJUI Compass 2023, 5: 142-149. PMID: 38179031, PMCID: PMC10764160, DOI: 10.1002/bco2.277.Peer-Reviewed Original ResearchActive surveillanceProstate cancerGene expression testGenomic testingCancer riskPatient experienceGrade group 2 prostate cancerGleason Grade Group 1Risk prostate cancerGrade group 1Prostate cancer riskProstate cancer managementProstate cancer aggressivenessHereditary cancer riskGermline genetic testsTissue-based testsGenomic test resultsConclusions PatientsInitial biopsyPhysician recommendationPatient knowledgePatient counsellingConventional content analysisCancer managementExpression testPatient experiences with tissue-based genomic testing during active surveillance for prostate cancer.
Leapman M, Sutherland R, Gross C, Ma X, Jeong F, Seibert T, Cooperberg M, Catalona W, Loeb S, Schulman-Green D. Patient experiences with tissue-based genomic testing during active surveillance for prostate cancer. Journal Of Clinical Oncology 2023, 41: 333-333. DOI: 10.1200/jco.2023.41.6_suppl.333.Peer-Reviewed Original ResearchActive surveillanceProstate cancerGene expression testGenomic testingCancer riskPatient experienceGleason Grade Group 1Risk prostate cancerGrade group 1Routine clinical careProstate cancer riskGroup 2 tumorsProstate cancer managementProstate cancer aggressivenessHereditary cancer riskGermline genetic testsTissue-based testsRace/ethnicityInitial biopsyPatient knowledgeMean agePatient counselingCancer managementClinical careExpression test
2022
Prominent Pseudoacini in Focal Nodular Hyperplasia
Wang D, González IA, Russo PA, Jain D, Zhang X. Prominent Pseudoacini in Focal Nodular Hyperplasia. The American Journal Of Surgical Pathology 2022, 46: 1380-1385. PMID: 35749760, DOI: 10.1097/pas.0000000000001931.Peer-Reviewed Original ResearchConceptsFocal nodular hyperplasiaHepatocellular carcinomaNodular hyperplasiaFNH casesPotential diagnostic pitfallInspissated bileChronic cholestasisInitial biopsyPathologic featuresClinicopathologic correlationDiagnostic challengeNeedle biopsyDifferential diagnosisHepatocellular neoplasmsHepatocellular adenomaDiagnostic pitfallsMorphologic featuresLobular parenchymaStaining patternPseudoaciniBiliary transdifferentiationBiopsyHyperplasiaLesionsHepatocytes
2021
Prevalence and Predictors of Missed Dysplasia on Index Barrett’s Esophagus Diagnosing Endoscopy in a Veteran Population
Nguyen T, Thrift A, George R, Rosen D, El-Serag H, Ketwaroo G. Prevalence and Predictors of Missed Dysplasia on Index Barrett’s Esophagus Diagnosing Endoscopy in a Veteran Population. Clinical Gastroenterology And Hepatology 2021, 20: e876-e889. PMID: 33839273, PMCID: PMC8900254, DOI: 10.1016/j.cgh.2021.04.008.Peer-Reviewed Original ResearchConceptsBarrett's esophagusIndex esophagogastroduodenoscopyIndefinite dysplasiaBE diagnosisLong-segment Barrett's esophagusProportion of patientsSegment Barrett's esophagusDysplastic Barrett's esophagusLogistic regression modelsBE lengthDefinite dysplasiaHouston VANDBE patientsClose followInitial biopsyDysplasia surveillanceBE patientsEndoscopic samplingRisk factorsOdds ratioEsophagogastroduodenoscopyRetrospective analysisPatientsVeteran populationDysplasia
2019
Clinicopathologic Factors Associated With Response to Neoadjuvant Anti-HER2–Directed Chemotherapy in HER2-Positive Breast Cancer
Meisel J, Zhao J, Suo A, Zhang C, Wei Z, Taylor C, Aneja R, Krishnamurti U, Li Z, Nahta R, O'Regan R, Li X. Clinicopathologic Factors Associated With Response to Neoadjuvant Anti-HER2–Directed Chemotherapy in HER2-Positive Breast Cancer. Clinical Breast Cancer 2019, 20: 19-24. PMID: 31806448, DOI: 10.1016/j.clbc.2019.09.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorBreastBreast NeoplasmsCarcinoma, Ductal, BreastChemotherapy, AdjuvantDNA Copy Number VariationsDrug Resistance, NeoplasmFeasibility StudiesFemaleHumansLymphocytes, Tumor-InfiltratingMastectomyMiddle AgedNeoadjuvant TherapyPredictive Value of TestsProgression-Free SurvivalReceptor, ErbB-2Receptors, EstrogenReceptors, ProgesteroneTumor BurdenConceptsTumor-infiltrating lymphocytesHER2-positive breast cancerNeoadjuvant therapyHER2/CEP17 ratioBreast cancerClinicopathologic featuresTumor sizeEstrogen receptorKi-67High HER2/CEP17 ratioCEP17 ratioHER2 immunohistochemistry 3Pathologic complete responseProgesterone receptor expressionSmaller tumor sizeBreast cancer responseHigh Ki-67Low estrogen receptorHER2 copy numberRCB-IIPatient ageClinicopathologic factorsComplete responseInitial biopsyExcisional specimensAn Algorithm for the Management of Residual Head and Neck Melanoma In Situ Using Topical Imiquimod: A Pilot Study.
Tsay C, Kim S, Norwich-Cavanaugh A, Hsia HC, Narayan D. An Algorithm for the Management of Residual Head and Neck Melanoma In Situ Using Topical Imiquimod: A Pilot Study. Annals Of Plastic Surgery 2019, 82: s199-s201. PMID: 30855388, DOI: 10.1097/sap.0000000000001840.Peer-Reviewed Original ResearchConceptsTopical imiquimodNeck melanomaSurgical excisionCure rateAtypical squamous cell carcinomaComparable cure ratesSquamous cell carcinomaDuration of treatmentLength of treatmentFrequency of treatmentStage T1aActive inflammationStandard therapyInitial biopsyResidual inflammationPatient adherencePositive marginsResidual diseaseCell carcinomaCertain patientsSkin biopsiesComplete excisionFunctional impairmentInclusion criteriaDifficult lesions
2017
Interstitial inflammation and interstitial fibrosis and tubular atrophy predict renal survival in lupus nephritis
Wilson PC, Kashgarian M, Moeckel G. Interstitial inflammation and interstitial fibrosis and tubular atrophy predict renal survival in lupus nephritis. Clinical Kidney Journal 2017, 11: 207-218. PMID: 29644061, PMCID: PMC5888814, DOI: 10.1093/ckj/sfx093.Peer-Reviewed Original ResearchRenal survivalWorse renal survivalInterstitial inflammationLupus nephritisInterstitial fibrosisTubular atrophyInflammation gradeClass IVEnd-stage renal diseaseRenal Pathology Society classificationCox proportional hazards modelBiopsy-proven lupusChronic glomerular lesionsProportional hazards modelDose-dependent mannerBaseline characteristicsSerum creatinineInitial biopsyRenal diseaseClinical outcomesGlomerular lesionsStratifies riskMedical recordsSociety classificationMultivariable modelActive Surveillance in Younger Men With Prostate Cancer
Leapman MS, Cowan JE, Nguyen HG, Shinohara KK, Perez N, Cooperberg MR, Catalona WJ, Carroll PR. Active Surveillance in Younger Men With Prostate Cancer. Journal Of Clinical Oncology 2017, 35: jco.2016.68.005. PMID: 28346806, PMCID: PMC5466007, DOI: 10.1200/jco.2016.68.0058.Peer-Reviewed Original ResearchConceptsBiopsy-based Gleason scoreActive surveillanceAssociation of ageProstate cancerDefinitive treatmentRadical prostatectomyYounger patientsGleason scoreMultivariable Cox proportional hazards regressionYounger ageLow-risk prostate cancerCox proportional hazards regressionGleason score upgradeInitial active surveillanceRelated end pointsCox regression analysisKaplan-Meier methodYounger patient ageProportional hazards regressionPrimary study objectiveInitial biopsyMedian agePatient ageHazards regressionBiochemical outcomes
2015
Atypical Small Acinar Proliferation: Repeat Biopsy and Detection of High Grade Prostate Cancer
Leone A, Rotker K, Butler C, Mega A, Li J, Amin A, Schiff SF, Pareek G, Golijanin D, Renzulli JF. Atypical Small Acinar Proliferation: Repeat Biopsy and Detection of High Grade Prostate Cancer. Prostate Cancer 2015, 2015: 810159. PMID: 26451257, PMCID: PMC4584238, DOI: 10.1155/2015/810159.Peer-Reviewed Original ResearchAtypical small acinar proliferationRisk prostate cancerHigh-risk prostate cancerRepeat biopsyProstate cancerProstate biopsyDiagnosis of ASAPIntermediate-risk prostate cancerHigh-grade prostate cancerSubsequent prostate biopsySmall acinar proliferationPatients of patientsMulti-institutional cohortSubsequent prostate cancerGrade prostate cancerGG 3Gleason grade 3Initial biopsyPatient characteristicsClinicopathologic featuresAcinar proliferationSubsequent diagnosisGrade 3BiopsyPatients
2005
Ileostomy Adenocarcinomas in the Setting of Ulcerative Colitis
Achneck HE, Wong IY, Kim PJ, Fernandes MA, Walther Z, Seymour NE, Jain D. Ileostomy Adenocarcinomas in the Setting of Ulcerative Colitis. Journal Of Clinical Gastroenterology 2005, 39: 396-400. PMID: 15815208, DOI: 10.1097/01.mcg.0000159216.39795.4a.Peer-Reviewed Case Reports and Technical NotesConceptsUlcerative colitisIleostomy siteLongstanding ulcerative colitisCases of adenocarcinomaSignet ring cellsAbundant extracellular mucinFamilial adenomatous polyposis coliIleostomy adenocarcinomaKock ileostomyMarked inflammationTotal proctocolectomyInitial biopsySubsequent biopsyCrohn's diseaseColon resectionNew ileostomyCytologic atypiaPrior historyExtracellular mucinAdenocarcinomaColitisIleostomyRare occurrenceDiseaseAdenomatous polyposis coli
2001
Dysplasia as a predictive marker for invasive carcinoma in Barrett esophagus: A follow-up study based on 138 cases from a diagnostic variability study
Montgomery E, Goldblum J, Greenson J, Haber M, Lamps L, Lauwers G, Lazenby A, Lewin D, Robert M, Washington K, Zahurak M, Hart J. Dysplasia as a predictive marker for invasive carcinoma in Barrett esophagus: A follow-up study based on 138 cases from a diagnostic variability study. Human Pathology 2001, 32: 379-388. PMID: 11331954, DOI: 10.1053/hupa.2001.23511.Peer-Reviewed Original ResearchConceptsHigh-grade dysplasiaLow-grade dysplasiaBarrett's esophagusInvasive carcinomaMajority diagnosisCases of HGDCases of LGDCases of BEEndoscopic biopsy specimensKaplan-Meier statisticsInitial biopsyEndoscopic surveillanceUlcerated areaGastrointestinal pathologyBiopsy specimenPredictive markerBiopsy diagnosisBiopsy specimensIntramucosal carcinomaPrecursor lesionsIND casesPowerful prognosticatorCarcinomaMorphologic evaluationUlcerated cases
1998
Clinical and pathologic tumor characteristics of prostate cancer as a function of the number of biopsy cores: a retrospective study
Naughton C, Smith D, Humphrey P, Catalona W, Keetch D. Clinical and pathologic tumor characteristics of prostate cancer as a function of the number of biopsy cores: a retrospective study. Urology 1998, 52: 808-813. PMID: 9801104, DOI: 10.1016/s0090-4295(98)00344-6.Peer-Reviewed Original ResearchConceptsProstate cancerBiopsy coresCore biopsySextant core biopsiesProstate volumeTotal prostate-specific antigen valuesProstate-specific antigen valuesMore biopsy coresMore biopsy sessionsPathologic tumor characteristicsPathologic tumor featuresSix-core biopsyTotal biopsy coresTRUS prostate volumeNegative prostate biopsyClinical prostate cancerMore biopsy samplesProstate cancer detectionPSA densityProspective trialInitial biopsyPathologic characteristicsProstatic volumeSerum tPSATumor characteristics
1997
Clinical significance of repeat sextant biopsies in prostate cancer patients
Stroumbakis N, Cookson M, Reuter V, Fair W. Clinical significance of repeat sextant biopsies in prostate cancer patients. Urology 1997, 49: 113-118. PMID: 9123730, DOI: 10.1016/s0090-4295(97)00178-7.Peer-Reviewed Original ResearchConceptsProstate-specific antigenOrgan-confined rateMargin-positive rateProstate cancerPSA densityRebiopsy resultsRepeat biopsySextant biopsyFinal surgical margin statusRandom systematic core biopsiesGreater prostate volumeNegative repeat biopsyAndrogen deprivation therapySurgical margin statusLower clinical stageProstate cancer patientsSignificant prostate cancerBiopsy-proven prostate cancerDeprivation therapyPositive rebiopsyConsecutive patientsInitial biopsyMargin statusProstate volumeT stage
1996
Repeat biopsy strategy in men with isolated prostatic intraepithelial neoplasia on prostate needle biopsy.
Shepherd D, Keetch D, Humphrey P, Smith D, Stahl D. Repeat biopsy strategy in men with isolated prostatic intraepithelial neoplasia on prostate needle biopsy. Journal Of Urology 1996, 156: 460-2; discussion 462-3. PMID: 8683703, DOI: 10.1097/00005392-199608000-00038.Peer-Reviewed Original ResearchConceptsHigh-grade prostatic intraepithelial neoplasiaGrade prostatic intraepithelial neoplasiaProstatic intraepithelial neoplasiaIntraepithelial neoplasiaRepeat biopsyNeedle biopsyBiopsy techniqueSide of cancerProstate needle biopsyLocation of cancerInitial biopsySystematic biopsyMen 31Biopsy strategyBiopsyNeoplasiaCancerProstateQuadrant locationStrongest predictorPatientsMenSame sideMalignancyDiseaseRepeat Biopsy Strategy in Men with Isolated Prostatic Intraepithelial Neoplasia on Prostate Needle Biopsy
Shepherd D, Keetch D, Humphrey P, Smith D, Stahl D. Repeat Biopsy Strategy in Men with Isolated Prostatic Intraepithelial Neoplasia on Prostate Needle Biopsy. Journal Of Urology 1996, 156: 460-463. DOI: 10.1016/s0022-5347(01)65881-6.Peer-Reviewed Original ResearchConceptsHigh-grade prostatic intraepithelial neoplasiaGrade prostatic intraepithelial neoplasiaProstatic intraepithelial neoplasiaIntraepithelial neoplasiaRepeat biopsyNeedle biopsyBiopsy techniqueSide of cancerProstate needle biopsyLocation of cancerPercent of casesInitial biopsySystematic biopsyMen 31Biopsy strategyBiopsyNeoplasiaCancerProstateQuadrant locationPatientsStrongest predictorMenSame sideMalignancy
1995
Morphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate
Keetch D, Humphrey P, Stahl D, Smith D, Catalona W. Morphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate. Journal Of Urology 1995, 154: 347-351. DOI: 10.1016/s0022-5347(01)67044-7.Peer-Reviewed Original ResearchConceptsProstatic intraepithelial neoplasiaHigh-grade prostatic intraepithelial neoplasiaGrade prostatic intraepithelial neoplasiaSerum PSA concentrationRepeat biopsyIntraepithelial neoplasiaProstate needle biopsyProstate-specific antigenNeedle biopsyInitial biopsyProstate cancerNumber of fociElevated serum PSA concentrationInitial prostate needle biopsyPSA concentrationMen 50 yearsPredictors of cancerDigital rectal examinationInitial biopsy specimenCancer detection rateFinding of cancerSignificance of gradeClinical followupPSA densityPatient ageMorphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate
Keetch D, Humphrey P, Stahl D, Smith D, Catalona W. Morphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate. Journal Of Urology 1995, 154: 347-351.. PMID: 7541850, DOI: 10.1097/00005392-199508000-00003.Peer-Reviewed Original ResearchConceptsProstatic intraepithelial neoplasiaHigh-grade prostatic intraepithelial neoplasiaGrade prostatic intraepithelial neoplasiaSerum PSA concentrationRepeat biopsyIntraepithelial neoplasiaProstate needle biopsyProstate-specific antigenNeedle biopsyInitial biopsyProstate cancerNumber of fociElevated serum PSA concentrationInitial prostate needle biopsyPSA concentrationMen 50 yearsPredictors of cancerDigital rectal examinationInitial biopsy specimenCancer detection rateFinding of cancerSignificance of gradeClinical followupPSA densityPatient age
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