2024
Effectiveness of primary repair for low anorectal malformations in Uganda
Oyania F, Ullrich S, Hellmann Z, Stephens C, Kotagal M, Commander S, Shui A, Situma M, Odongo C, Kituuka O, Bajunirwe F, Ozgediz D, Poenaru D. Effectiveness of primary repair for low anorectal malformations in Uganda. Pediatric Surgery International 2024, 40: 315. PMID: 39560775, PMCID: PMC12032398, DOI: 10.1007/s00383-024-05905-8.Peer-Reviewed Original ResearchConceptsThree-stage repairTwo-stage repairPrimary repairLength of hospital stayLow anorectal malformationPost-operative complicationsLonger treatment durationLength of treatmentNon-inferiority analysisResource-limited settingsBackgroundAnorectal malformationsNeonatal surgeryProspective armRetrospective armAnorectal malformationsPostoperative complicationsSurgeon experienceColostomy closureHospital stayLive birthsSurgical accessColostomy formationUgandan childrenNon-inferiorityClinical trials
2020
Associations between stopping prescriptions for opioids, length of opioid treatment, and overdose or suicide deaths in US veterans: observational evaluation
Oliva E, Bowe T, Manhapra A, Kertesz S, Hah J, Henderson P, Robinson A, Paik M, Sandbrink F, Gordon A, Trafton J. Associations between stopping prescriptions for opioids, length of opioid treatment, and overdose or suicide deaths in US veterans: observational evaluation. The BMJ 2020, 368: m283. PMID: 32131996, PMCID: PMC7249243, DOI: 10.1136/bmj.m283.Peer-Reviewed Original ResearchConceptsLength of treatmentVeterans Health AdministrationOpioid treatmentHealth AdministrationLong patientsObservational evaluationRisk of deathHazards regression modelsFocus of guidelinesLong-term useOpioid cessationOpioid prescriptionsOpioid analgesicsOutpatient prescriptionsPlace patientsSafe prescribingPatient deathUS veteransNon-proportional hazards regression modelsPatient's perspectiveFiscal year 2014OpioidsPatientsOverdoseGreater risk
2019
An Algorithm for the Management of Residual Head and Neck Melanoma In Situ Using Topical Imiquimod: A Pilot Study.
Tsay C, Kim S, Norwich-Cavanaugh A, Hsia HC, Narayan D. An Algorithm for the Management of Residual Head and Neck Melanoma In Situ Using Topical Imiquimod: A Pilot Study. Annals Of Plastic Surgery 2019, 82: s199-s201. PMID: 30855388, DOI: 10.1097/sap.0000000000001840.Peer-Reviewed Original ResearchConceptsTopical imiquimodNeck melanomaSurgical excisionCure rateAtypical squamous cell carcinomaComparable cure ratesSquamous cell carcinomaDuration of treatmentLength of treatmentFrequency of treatmentStage T1aActive inflammationStandard therapyInitial biopsyResidual inflammationPatient adherencePositive marginsResidual diseaseCell carcinomaCertain patientsSkin biopsiesComplete excisionFunctional impairmentInclusion criteriaDifficult lesions
2018
Factors Associated With Postmarketing Research for Approved Indications for Novel Medicines Approved by Both the FDA and EMA Between 2005 and 2010: A Multivariable Analysis
Zeitoun J, Ross JS, Atal I, Vivot A, Downing NS, Baron G, Ravaud P. Factors Associated With Postmarketing Research for Approved Indications for Novel Medicines Approved by Both the FDA and EMA Between 2005 and 2010: A Multivariable Analysis. Clinical Pharmacology & Therapeutics 2018, 104: 1000-1007. PMID: 29377075, DOI: 10.1002/cpt.1038.Peer-Reviewed Original Research
2017
Evaluation of an Integrated, Multidisciplinary Program to Address Unsafe Use of Opioids Prescribed for Pain
Becker WC, Edmond SN, Cervone DJ, Manhapra A, Sellinger JJ, Moore BA, Edens EL. Evaluation of an Integrated, Multidisciplinary Program to Address Unsafe Use of Opioids Prescribed for Pain. Pain Medicine 2017, 19: 1419-1424. PMID: 28371816, DOI: 10.1093/pm/pnx041.Peer-Reviewed Original ResearchConceptsPreliminary efficacyUnsafe useSubstance abuse/dependenceMultidisciplinary care teamSubstance use disorder diagnosisPrimary care physiciansAdvanced practice nursesUrine drug testingLength of treatmentStructured clinical assessmentNurse case managersAbuse/dependenceHealth system levelHigh-complexity patientsElectronic progress notesOpioid prescribedOpioid receiptCare physiciansPractice nursesPrimary careCare coordinationCare teamClinical assessmentCare modelClinic processes
2014
Clinical Trial Evidence Supporting FDA Approval of Novel Therapeutic Agents, 2005-2012
Downing NS, Aminawung JA, Shah ND, Krumholz HM, Ross JS. Clinical Trial Evidence Supporting FDA Approval of Novel Therapeutic Agents, 2005-2012. JAMA 2014, 311: 368-377. PMID: 24449315, PMCID: PMC4144867, DOI: 10.1001/jama.2013.282034.Peer-Reviewed Original ResearchConceptsPivotal efficacy trialsNovel therapeutic agentsClinical trial evidencePivotal trialsEfficacy trialsTherapeutic agentsEnd pointTrial evidenceMedian numberAvailable FDA documentsSingle pivotal trialTrial end pointsSurrogate end pointsNumber of patientsLength of treatmentCross-sectional analysisPrimary outcomeClinical outcomesTrial completion ratesClinical benefitPlacebo comparatorSurrogate outcomesMAIN OUTCOMEDrug AdministrationUS Food
2009
HCV Response in Patients With End Stage Renal Disease Treated With Combination Pegylated Interferon α-2a and Ribavirin
Hakim W, Sheikh S, Inayat I, Caldwell C, Smith D, Lorber M, Friedman A, Jain D, Bia M, Formica R, Mehal W. HCV Response in Patients With End Stage Renal Disease Treated With Combination Pegylated Interferon α-2a and Ribavirin. Journal Of Clinical Gastroenterology 2009, 43: 477-481. PMID: 19142165, PMCID: PMC3715868, DOI: 10.1097/mcg.0b013e318180803a.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseHepatitis C virusCombination therapyRenal diseasePosttreatment rateSide effectsSerious adverse side effectsDose of ribavirinNon-ESRD patientsSafe therapeutic optionEarly virologic responseProspective observational studyMonths of treatmentStage renal diseaseCases of anemiaInitial response rateLength of treatmentInterferon α-2aAdverse side effectsPO weeklyVirologic responseESRD patientsHCV infectionESRD populationHCV response
1999
Infertility Treatment and Informed Consent
HOUMARD B, SEIFER D. Infertility Treatment and Informed Consent. Obstetrics And Gynecology 1999, 93: 252-257. DOI: 10.1097/00006250-199902000-00018.Peer-Reviewed Original ResearchOvulation inductionCurrent practice patternsInfertility treatmentOvarian cancerReproductive endocrinologistsInformed consentIntrauterine inseminationPractice patternsMost physiciansBoard-certified reproductive endocrinologistsReproductive technologiesPatients of risksOvarian cancer riskLength of treatmentLogistic regression analysisMajority of physiciansAssisted Reproductive TechnologyInvasive therapyCancer riskVerbal consentPossible associationCancerEndocrinologistsPhysiciansCommon changesInfertility treatment and informed consent: current practices of reproductive endocrinologists.
Houmard BS, Seifer DB. Infertility treatment and informed consent: current practices of reproductive endocrinologists. Obstetrics And Gynecology 1999, 93: 252-7. PMID: 9932565, DOI: 10.1016/s0029-7844(98)00389-5.Peer-Reviewed Original ResearchConceptsOvulation inductionCurrent practice patternsInfertility treatmentOvarian cancerReproductive endocrinologistsInformed consentIntrauterine inseminationPractice patternsMost physiciansBoard-certified reproductive endocrinologistsReproductive technologiesPatients of risksOvarian cancer riskLength of treatmentLogistic regression analysisMajority of physiciansAssisted Reproductive TechnologyInvasive therapyCancer riskVerbal consentPossible associationEndocrinologistsCancerPhysiciansCommon changes
1992
Listening to our clinical partners: Informing researchers about children's fears and phobias
Silverman W, Kearley C. Listening to our clinical partners: Informing researchers about children's fears and phobias. Journal Of Behavior Therapy And Experimental Psychiatry 1992, 23: 71-76. PMID: 1460102, DOI: 10.1016/0005-7916(92)90003-2.Peer-Reviewed Original ResearchConceptsTypes of fearFears/phobiasIntensity of fearLength of treatmentLength of historyType of treatmentChildren's fearsClinical psychologistsTreatment characteristicsParental involvementPhobiaFearFuture researchClinical partnersNational sampleTreatmentTreatment methodsEmpirical baseChildrenImportant linePsychologistsGrazianoCliniciansFindings
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