2018
Intrahepatic Cholangiocarcinomas Have Histologically and Immunophenotypically Distinct Small and Large Duct Patterns
Sigel C, Drill E, Zhou Y, Basturk O, Askan G, Pak L, Vakiani E, Wang T, Boerner T, Do R, Simpson A, Jarnagin W, Klimstra D. Intrahepatic Cholangiocarcinomas Have Histologically and Immunophenotypically Distinct Small and Large Duct Patterns. The American Journal Of Surgical Pathology 2018, 42: 1334-1345. PMID: 30001234, PMCID: PMC6657522, DOI: 10.1097/pas.0000000000001118.Peer-Reviewed Original ResearchMeSH KeywordsAgedBile Duct NeoplasmsBile Ducts, IntrahepaticBiomarkers, TumorBiopsyCholangiocarcinomaDatabases, FactualFemaleHumansImmunohistochemistryImmunophenotypingIn Situ HybridizationMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPhenotypeProgression-Free SurvivalRetrospective StudiesConceptsPT stageIntrahepatic cholangiocarcinomaSmall ductsAssociated with mucin productionCA19-9 stainingRecurrence-free survivalResected intrahepatic cholangiocarcinomaPrimary sclerosing cholangitisAssociated with subtypesRNA in situ hybridizationPositive tumorsPerineural invasionPeriductal infiltrationHistological typeFrequent alcohol useSclerosing cholangitisImmunophenotypic characteristicsS100P expressionExtracellular mucinChronic hepatitisHistologic associationDuct patternMultivariate analysisRisk factorsMucin production
2005
Ileostomy Adenocarcinomas in the Setting of Ulcerative Colitis
Achneck HE, Wong IY, Kim PJ, Fernandes MA, Walther Z, Seymour NE, Jain D. Ileostomy Adenocarcinomas in the Setting of Ulcerative Colitis. Journal Of Clinical Gastroenterology 2005, 39: 396-400. PMID: 15815208, DOI: 10.1097/01.mcg.0000159216.39795.4a.Peer-Reviewed Case Reports and Technical NotesConceptsUlcerative colitisIleostomy siteLongstanding ulcerative colitisCases of adenocarcinomaSignet ring cellsAbundant extracellular mucinFamilial adenomatous polyposis coliIleostomy adenocarcinomaKock ileostomyMarked inflammationTotal proctocolectomyInitial biopsySubsequent biopsyCrohn's diseaseColon resectionNew ileostomyCytologic atypiaPrior historyExtracellular mucinAdenocarcinomaColitisIleostomyRare occurrenceDiseaseAdenomatous polyposis coli
2003
Pathogenesis of Colloid (Pure Mucinous) Carcinoma of Exocrine Organs
Adsay V, Merati K, Nassar H, Shia J, Sarkar F, Pierson C, Cheng J, Visscher D, Hruban R, Klimstra D. Pathogenesis of Colloid (Pure Mucinous) Carcinoma of Exocrine Organs. The American Journal Of Surgical Pathology 2003, 27: 571-578. PMID: 12717243, DOI: 10.1097/00000478-200305000-00002.Peer-Reviewed Original ResearchConceptsStroma-facing surfaceDuctal carcinomaNormal ductsImmunohistochemical stainingMucigen granulesLakes of mucinConventional ductal carcinomaExocrine organsPoorly differentiated areasCell-stroma interactionsTumor suppressor activityCC cellsSurface glycoproteinColloid carcinomaExtracellular mucinConventional carcinomasMalignant cellsTumor cellsGrowth of CCBasal lamina formationExpression frequencyMUC2 expressionNormal tissuesStromaSuppressor activity
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