2024
Crosstalk between CD8+ T cells and mesenchymal stromal cells in intestine homeostasis and immunity
Chen Y, Sun H, Luo Z, Mei Y, Xu Z, Tan J, Xie Y, Li M, Xia J, Yang B, Su B. Crosstalk between CD8+ T cells and mesenchymal stromal cells in intestine homeostasis and immunity. Advances In Immunology 2024, 162: 23-58. PMID: 38866438, DOI: 10.1016/bs.ai.2024.02.001.Peer-Reviewed Original ResearchCD8+ T cellsMesenchymal stromal cell populationT cellsStromal cell populationsMHC II moleculesMesenchymal stromal cellsStromal cellsFunction of CD8+ T cellsCD103+ dendritic cellsMHC-IIIntestinal homeostasisCell populationsPotential pathophysiological impactGut-associated lymphoid tissueIgA+ plasma cellsDiseases of inflammationDead cell debrisTissue residencyDendritic cellsFood antigensIL-33Plasma cellsIntestinal toleranceLymphoid tissueImmunostimulatory agentsDifferential Regulation of the Type 2 Cytokines, IL-4 and IL-13, and the Alarmins, IL-33 and TSLPA, in Airway Inflammation and Remodeling
Asrat S, Srivatsan S, Buonagurio B, Nagashima K, Scott G, Gayvert K, Lim W, Ben L, Le Floc’h A, Murphy A, Sleeman M, Orengo J. Differential Regulation of the Type 2 Cytokines, IL-4 and IL-13, and the Alarmins, IL-33 and TSLPA, in Airway Inflammation and Remodeling. 2024, a3276-a3276. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a3276.Peer-Reviewed Original Research
2023
The VCAM1–ApoE pathway directs microglial chemotaxis and alleviates Alzheimer’s disease pathology
Lau S, Wu W, Wong H, Ouyang L, Qiao Y, Xu J, Lau J, Wong C, Jiang Y, Holtzman D, Fu A, Ip N. The VCAM1–ApoE pathway directs microglial chemotaxis and alleviates Alzheimer’s disease pathology. Nature Aging 2023, 3: 1219-1236. PMID: 37735240, PMCID: PMC10570140, DOI: 10.1038/s43587-023-00491-1.Peer-Reviewed Original ResearchConceptsDanger-associated molecular patternsAlzheimer's diseaseMicroglial chemotaxisAmeliorate AD pathologyDisease pathologyAlzheimer's disease pathologyAmyloid-betaFunctional screeningPlaque-associatedMicroglial clearanceAD pathologyExtrinsic signalsPhagocytic clearanceExacerbate disease pathologyMolecular patternsIL-33ChemotaxisMicroglial functionAlzheimerVCAM1Interleukin-33Higher cerebrospinal fluid levelsApoPathwayMicroglia
2021
IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2
Goldberg EL, Shchukina I, Youm YH, Ryu S, Tsusaka T, Young KC, Camell CD, Dlugos T, Artyomov MN, Dixit VD. IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2. Cell Metabolism 2021, 33: 2277-2287.e5. PMID: 34473956, PMCID: PMC9067336, DOI: 10.1016/j.cmet.2021.08.004.Peer-Reviewed Original ResearchConceptsOld miceType 2 innate lymphoid cellsInnate lymphoid cellsTissue-resident cellsCore body temperatureAdoptive transferIL-33ILC2 numbersTissue inflammationAged miceImmunometabolic responsesMetabolic impairmentLymphoid cellsDietary restrictionImmune systemILC2Functional defectsMiceBody temperatureFailureCellsInflammationTranscriptomic analysisInfectionStress responseThe Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis
García-Arellano S, Hernández-Palma L, Cerpa-Cruz S, Sánchez-Zuno G, Herrera-Godina M, Muñoz-Valle J. The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis. Molecules 2021, 26: 4968. PMID: 34443554, PMCID: PMC8398282, DOI: 10.3390/molecules26164968.Peer-Reviewed Original ResearchConceptsSecretion of IL-25Peripheral blood mononuclear cellsMacrophage migration inhibitory factorIL-25IL-33IL-31Rheumatoid arthritisRA patientsPeripheral blood mononuclear cells of patientsPeripheral blood mononuclear cells of RA patientsAutoimmune inflammatory joint diseaseImmune-modulatory cytokinesBlood mononuclear cellsIL-33 secretionMigration inhibitory factorCytokine dysregulationSystemic inflammationInflammatory joint diseaseMononuclear cellsImmunomodulatory effectsStudy groupPatient treatmentInhibitory factorJoint destructionPatients
2017
TH17 cells express ST2 and are controlled by the alarmin IL-33 in the small intestine
Pascual-Reguant A, Sarmadi J, Baumann C, Noster R, Cirera-Salinas D, Curato C, Pelczar P, Huber S, Zielinski CE, Löhning M, Hauser AE, Esplugues E. TH17 cells express ST2 and are controlled by the alarmin IL-33 in the small intestine. Mucosal Immunology 2017, 10: 1431-1442. PMID: 28198366, DOI: 10.1038/mi.2017.5.Peer-Reviewed Original ResearchConceptsPro-inflammatory TH17 cellsIntestinal epithelial cellsTh17 cellsSmall intestineIL-33IL-33/ST2 axisPro-inflammatory T cellsAlarmin IL-33Alarmin interleukin-33IL-33 receptorPro-inflammatory cytokinesAbsence of ST2Beneficial host responseIL-10Interleukin-33Autoimmune diseasesTissue inflammationInflammatory responseImmunosuppressive propertiesT cellsImmune responseInflamed tissuesHost responseImmune systemRegulatory phenotype
2016
Snapshots of CD4 + T cell plasticity in the pathogenesis of allergic asthma
Chae WJ, Bothwell AL. Snapshots of CD4 + T cell plasticity in the pathogenesis of allergic asthma. Journal Of Thoracic Disease 2016, 8: e1010-e1012. PMID: 27747048, PMCID: PMC5059289, DOI: 10.21037/jtd.2016.08.19.Peer-Reviewed Original ResearchThymic stromal lymphopoietinHouse dust miteAllergic asthmaDendritic cellsType 2 inflammatory diseasesT helper type 2 cellsNaïve CD4 T cellsCD4 T cellsHumoral immune responseTh2 effector cellsT cell plasticityType 2 cellsLung epithelial cellsIL-25Lung eosinophiliaIL-33Effector cellsEnvironmental allergensTh2 cytokinesDust miteInflammatory diseasesT cellsImmune responseB cellsEpithelial cells
2015
Effect of TNF-α inhibitors on transcriptional levels of pro-inflammatory interleukin-33 and Toll-like receptors-2 and -9 in psoriatic plaques
VAGELI DP, EXARCHOU A, ZAFIRIOU E, DOUKAS PG, DOUKAS S, ROUSSAKI-SCHULZE A. Effect of TNF-α inhibitors on transcriptional levels of pro-inflammatory interleukin-33 and Toll-like receptors-2 and -9 in psoriatic plaques. Experimental And Therapeutic Medicine 2015, 10: 1573-1577. PMID: 26622528, PMCID: PMC4577938, DOI: 10.3892/etm.2015.2688.Peer-Reviewed Original ResearchTLR-2Psoriatic plaquesTNF-α inhibitorsIL-33PASI scoreTLR-9MRNA levelsPsoriasis Area Severity Index (PASI) scoreTNF-α inhibitor treatmentToll-like receptor 2Reverse transcription-quantitative polymerase chain reactionOpen-label studyTranscription-quantitative polymerase chain reactionWeeks of treatmentSeverity Index scorePro-inflammatory moleculesToll-like receptorsIL-1 receptorInnate immune responseElevated IL-33TNF-α treatmentMRNA expression ratioEtanercept groupPlaque psoriasisSignificant positive Pearson correlation
2011
Targeting ST2L Potentiates CpG-Mediated Therapeutic Effects in a Chronic Fungal Asthma Model
Ramaprakash H, Shibata T, Duffy KE, Ismailoglu UB, Bredernitz RM, Moreira AP, Coelho AL, Das AM, Fursov N, Chupp GL, Hogaboam CM. Targeting ST2L Potentiates CpG-Mediated Therapeutic Effects in a Chronic Fungal Asthma Model. American Journal Of Pathology 2011, 179: 104-115. PMID: 21640974, PMCID: PMC3123853, DOI: 10.1016/j.ajpath.2011.03.032.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAspergillosis, Allergic BronchopulmonaryAspergillus fumigatusAsthmaBlotting, WesternBronchial HyperreactivityCase-Control StudiesChemokine CXCL9Chronic DiseaseDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFemaleFibrosisHumansImmunoenzyme TechniquesImmunoglobulin GLungMiceMice, Inbred C57BLOligodeoxyribonucleotidesReceptors, Interleukin-1Reverse Transcriptase Polymerase Chain ReactionRNA, MessengerToll-Like Receptor 9ConceptsAsthmatic miceExperimental asthmaDendritic cellsTherapeutic effectDay 28Live A. fumigatus conidiaControl dendritic cellsMucus cell metaplasiaKey pathological featureCell-associated receptorsA. fumigatus conidiaProtein expression levelsAirway hyperresponsivenessCXCL9 levelsFungal asthmaPeribronchial fibrosisAsthma modelIL-12p70Time-dependent mannerAllergic inflammationAsthma severityCell metaplasiaIL-33Therapeutic blockadeC57BL/6 mice
2009
Inflammasomes in viral infection
Ichinohe T, Iwasaki A. Inflammasomes in viral infection. Uirusu 2009, 59: 13. PMID: 19927984, DOI: 10.2222/jsv.59.13.Peer-Reviewed Original ResearchConceptsNOD-like receptorsProinflammatory cytokine interleukin-1betaRole of inflammasomesInfluenza virus infectionCytokine interleukin-1betaInnate immune responseCaspase-1 activationIL-33IL-18NLRP3 inflammasomeVirus infectionImmune responseInterleukin-1betaAdaptive immunityInflammasome activationMicrobial motifsDamage-associated signalsViral infectionInflammasomeMultiprotein complexesAdaptor proteinInfectionCertain virusesCell deathIntracellular sensors
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