2025
Targeting eRNA‐Producing Super‐Enhancers Regulates TNFα Expression and Mitigates Chronic Inflammation in Mice and Patient‐Derived Immune Cells
Cho M, Kim S, Lee J, Kwon O, Woo W, Lee E, Park H, Lee Y, Dho S, Kim T, Park M, Flavell R, Kim L. Targeting eRNA‐Producing Super‐Enhancers Regulates TNFα Expression and Mitigates Chronic Inflammation in Mice and Patient‐Derived Immune Cells. Advanced Science 2025, e05214. PMID: 40692264, DOI: 10.1002/advs.202505214.Peer-Reviewed Original ResearchChronic inflammatory diseaseTNFA expressionTNFa levelsChronic inflammationPatient-derived immune cellsInflammatory diseasesRheumatoid arthritisTumor necrosis factor-alphaMitigate chronic inflammationImmune cell activationSuper-enhancersAntisense oligonucleotide (ASO)-mediated knockdownImmune cell dysregulationModel of rheumatoid arthritisNecrosis factor-alphaLipopolysaccharide (LPS)-induced sepsisPro-inflammatory moleculesEnhancer RNAsImmune cellsFactor-alphaCell dysregulationCell activationLPS responseHuman homologRA symptoms
2023
Maresin1 prevents sepsis-induced acute liver injury by suppressing NF-κB/Stat3/MAPK pathways, mitigating inflammation
Sun S, Wang L, Wang J, Chen R, Pei S, Yao S, Lin Y, Yao C, Xia H. Maresin1 prevents sepsis-induced acute liver injury by suppressing NF-κB/Stat3/MAPK pathways, mitigating inflammation. Heliyon 2023, 9: e21883. PMID: 38027581, PMCID: PMC10665730, DOI: 10.1016/j.heliyon.2023.e21883.Peer-Reviewed Original ResearchSepsis-induced acute liver injuryAcute liver injuryAnti-inflammatory effectsLiver injuryNeutrophil infiltrationBacterial loadSurvival rateDocosahexaenoic acidNormal saline 1Peritoneal lavage fluidPro-inflammatory moleculesTreatment of sepsisUncontrolled inflammatory responseAnti-inflammatory moleculesSepsis-induced injuryEffects of MaR1Body weight changesSepsis-related diseasesDose-dependent mannerSaline 1Septic miceCecal ligationLavage fluidLiver functionAcute inflammation
2020
Functional heterogeneity of alveolar macrophage population based on expression of CXCL2
Xu-Vanpala S, Deerhake ME, Wheaton JD, Parker ME, Juvvadi PR, MacIver N, Ciofani M, Shinohara ML. Functional heterogeneity of alveolar macrophage population based on expression of CXCL2. Science Immunology 2020, 5 PMID: 32769172, PMCID: PMC7717592, DOI: 10.1126/sciimmunol.aba7350.Peer-Reviewed Original ResearchConceptsPulmonary fungal infectionAlveolar macrophagesFungal infectionsAM subpopulationsPharmacological intervention targetPro-inflammatory moleculesLung-resident macrophagesAnti-inflammatory moleculesExpression of CXCL2Strong inflammatory responseAlveolar macrophage populationComplement component 1qDistinct metabolic profilesC1q expressionInterleukin-10Inflammatory responseSentinel cellsPhagocytic capacityMacrophage populationsCXCL2InfectionMetabolic profileIntervention targetsSubpopulationsAM population
2018
Uremia induces upregulation of cerebral tissue oxidative/inflammatory cascade, down-regulation of Nrf2 pathway and disruption of blood brain barrier.
Jing W, Jabbari B, Vaziri ND. Uremia induces upregulation of cerebral tissue oxidative/inflammatory cascade, down-regulation of Nrf2 pathway and disruption of blood brain barrier. American Journal Of Translational Research 2018, 10: 2137-2147. PMID: 30093950, PMCID: PMC6079125.Peer-Reviewed Original ResearchImpaired blood-brain barrierBlood-brain barrierCerebral cortexBrain barrierNF-κBBody weightChronic kidney disease (CKD) resultsInducible NO synthase isoformCentral nervous system disordersOxidative stressElevated serum ureaPro-inflammatory moleculesEndothelial junctional complexesNuclear translocationReduced body weightMale Sprague-DawleyTissue oxidative stressNervous system disordersNO synthase (NOS) isoformsCKD groupCKD ratsFibrosis mediatorsWestern blot analysisRenal functionArterial pressureImpaired type I interferon regulation in the blood transcriptome of recurrent asthma exacerbations
Gomez JL, Diaz MP, Nino G, Britto CJ. Impaired type I interferon regulation in the blood transcriptome of recurrent asthma exacerbations. BMC Medical Genomics 2018, 11: 21. PMID: 29486764, PMCID: PMC5830339, DOI: 10.1186/s12920-018-0340-3.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsAsthma exacerbationsInterferon-stimulated genesRespiratory infectionsIL-15Vivo cohortToll-like receptor 2STAT1 responseRecurrent asthma exacerbationsAcute asthma exacerbationPro-inflammatory moleculesType I interferon regulationBlood mononuclear cellsPro-inflammatory signatureTranscriptomic signaturesType I interferonFold changeAdult asthmaAcute phaseMononuclear cellsImmunologic genesExacerbationIndependent cohortReceptor 2I interferon
2015
Effect of TNF-α inhibitors on transcriptional levels of pro-inflammatory interleukin-33 and Toll-like receptors-2 and -9 in psoriatic plaques
VAGELI DP, EXARCHOU A, ZAFIRIOU E, DOUKAS PG, DOUKAS S, ROUSSAKI-SCHULZE A. Effect of TNF-α inhibitors on transcriptional levels of pro-inflammatory interleukin-33 and Toll-like receptors-2 and -9 in psoriatic plaques. Experimental And Therapeutic Medicine 2015, 10: 1573-1577. PMID: 26622528, PMCID: PMC4577938, DOI: 10.3892/etm.2015.2688.Peer-Reviewed Original ResearchTLR-2Psoriatic plaquesTNF-α inhibitorsIL-33PASI scoreTLR-9MRNA levelsPsoriasis Area Severity Index (PASI) scoreTNF-α inhibitor treatmentToll-like receptor 2Reverse transcription-quantitative polymerase chain reactionOpen-label studyTranscription-quantitative polymerase chain reactionWeeks of treatmentSeverity Index scorePro-inflammatory moleculesToll-like receptorsIL-1 receptorInnate immune responseElevated IL-33TNF-α treatmentMRNA expression ratioEtanercept groupPlaque psoriasisSignificant positive Pearson correlation
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