2023
The VCAM1–ApoE pathway directs microglial chemotaxis and alleviates Alzheimer’s disease pathology
Lau S, Wu W, Wong H, Ouyang L, Qiao Y, Xu J, Lau J, Wong C, Jiang Y, Holtzman D, Fu A, Ip N. The VCAM1–ApoE pathway directs microglial chemotaxis and alleviates Alzheimer’s disease pathology. Nature Aging 2023, 3: 1219-1236. PMID: 37735240, PMCID: PMC10570140, DOI: 10.1038/s43587-023-00491-1.Peer-Reviewed Original ResearchConceptsDanger-associated molecular patternsAlzheimer's diseaseMicroglial chemotaxisAmeliorate AD pathologyDisease pathologyAlzheimer's disease pathologyAmyloid-betaFunctional screeningPlaque-associatedMicroglial clearanceAD pathologyExtrinsic signalsPhagocytic clearanceExacerbate disease pathologyMolecular patternsIL-33ChemotaxisMicroglial functionAlzheimerVCAM1Interleukin-33Higher cerebrospinal fluid levelsApoPathwayMicroglia
2017
TH17 cells express ST2 and are controlled by the alarmin IL-33 in the small intestine
Pascual-Reguant A, Sarmadi J, Baumann C, Noster R, Cirera-Salinas D, Curato C, Pelczar P, Huber S, Zielinski CE, Löhning M, Hauser AE, Esplugues E. TH17 cells express ST2 and are controlled by the alarmin IL-33 in the small intestine. Mucosal Immunology 2017, 10: 1431-1442. PMID: 28198366, DOI: 10.1038/mi.2017.5.Peer-Reviewed Original ResearchConceptsPro-inflammatory TH17 cellsIntestinal epithelial cellsTh17 cellsSmall intestineIL-33IL-33/ST2 axisPro-inflammatory T cellsAlarmin IL-33Alarmin interleukin-33IL-33 receptorPro-inflammatory cytokinesAbsence of ST2Beneficial host responseIL-10Interleukin-33Autoimmune diseasesTissue inflammationInflammatory responseImmunosuppressive propertiesT cellsImmune responseInflamed tissuesHost responseImmune systemRegulatory phenotype
2013
Bee Venom Phospholipase A2 Induces a Primary Type 2 Response that Is Dependent on the Receptor ST2 and Confers Protective Immunity
Palm NW, Rosenstein RK, Yu S, Schenten DD, Florsheim E, Medzhitov R. Bee Venom Phospholipase A2 Induces a Primary Type 2 Response that Is Dependent on the Receptor ST2 and Confers Protective Immunity. Immunity 2013, 39: 976-985. PMID: 24210353, PMCID: PMC3852615, DOI: 10.1016/j.immuni.2013.10.006.Peer-Reviewed Original ResearchMeSH KeywordsAnaphylaxisAnimalsBee VenomsCrotalid VenomsGenes, ReporterImmunity, InnateImmunoglobulin EImmunoglobulin GInsect ProteinsInterleukin-1 Receptor-Like 1 ProteinInterleukin-33Interleukin-4InterleukinsLymphocyte ActivationLysophospholipidsMelittenMembrane LipidsMiceMice, Inbred BALB CMice, KnockoutMyeloid Differentiation Factor 88OvalbuminPhospholipases A2PhospholipidsReceptors, IgEReceptors, InterleukinTh2 CellsConceptsInnate immune systemBee venom phospholipase A2Components of venomPhospholipase A2Immune responseGroup 2 Innate Lymphoid Cell ActivationVenom phospholipase A2Immune systemInnate lymphoid cell activationType 2 immune responsesLymphoid cell activationType 2 responsesProtective immune responseConfer protective immunityIgE responseInterleukin-33Receptor ST2Protective immunityCell type responsesCell activationLethal doseMajor allergenBee venomAllergensVenom toxins
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