2016
Snapshots of CD4 + T cell plasticity in the pathogenesis of allergic asthma
Chae WJ, Bothwell AL. Snapshots of CD4 + T cell plasticity in the pathogenesis of allergic asthma. Journal Of Thoracic Disease 2016, 8: e1010-e1012. PMID: 27747048, PMCID: PMC5059289, DOI: 10.21037/jtd.2016.08.19.Peer-Reviewed Original ResearchThymic stromal lymphopoietinHouse dust miteAllergic asthmaDendritic cellsType 2 inflammatory diseasesT helper type 2 cellsNaïve CD4 T cellsCD4 T cellsHumoral immune responseTh2 effector cellsT cell plasticityType 2 cellsLung epithelial cellsIL-25Lung eosinophiliaIL-33Effector cellsEnvironmental allergensTh2 cytokinesDust miteInflammatory diseasesT cellsImmune responseB cellsEpithelial cells
2011
The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma
Zheng T, Yu J, Oh MH, Zhu Z. The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma. Allergy Asthma And Immunology Research 2011, 3: 67-73. PMID: 21461244, PMCID: PMC3062798, DOI: 10.4168/aair.2011.3.2.67.Peer-Reviewed Original ResearchPathogenesis of ADAtopic dermatitisAtopic marchAllergic rhinitisMechanisms of ADIgE-mediated sensitizationPruritic skin lesionsT helper 1More effective treatmentsAdaptive immune systemEpidermal barrier functionImmunological sequelaeEnvironmental allergensTh2 paradigmBarrier disruptionInflammatory diseasesSkin lesionsEffective treatmentEpithelial barrierImmune systemDisease initiationBarrier functionPrimary defectLongitudinal studyRhinitis
2010
Transgenic modelling of cytokine polarization in the lung
Dela Cruz CS, Kang M, Cho W, Lee CG. Transgenic modelling of cytokine polarization in the lung. Immunology 2010, 132: 9-17. PMID: 21091906, PMCID: PMC3015070, DOI: 10.1111/j.1365-2567.2010.03376.x.Peer-Reviewed Original ResearchConceptsCytokine polarizationT helper type 17 cytokinesT helper type 2T helper type 1Type 1Type 17 cytokinesHelper type 2Type 2 cytokinesHelper type 1Human lung diseasesVariety of cytokinesCytokine milieuPulmonary inflammationEnvironmental allergensLung diseaseTissue phenotypeInjury modelT-betCommon siteCertain cytokinesEffector functionsTransgenic miceIndividual cytokinesPathophysiological consequencesType 2
2006
Antenatal risk factors, cytokines and the development of atopic disease in early childhood
Chung E, Miller R, Wilson M, McGeady S, Culhane J. Antenatal risk factors, cytokines and the development of atopic disease in early childhood. Archives Of Disease In Childhood Fetal & Neonatal 2006, 92: f68. PMID: 17185433, PMCID: PMC2675311, DOI: 10.1136/adc.2006.106492.Peer-Reviewed Original ResearchConceptsAtopic diseasesRisk factorsAntenatal exposureT helper cell type 1T helper cell type 2 cytokinesPediatric atopic diseaseNeonatal immune responsesAntenatal risk factorsType 2 cytokinesCell type 1Early childhoodTh2 pathwayCytokine responsesEnvironmental allergensCord bloodIntrauterine environmentImmune responseGenetic predispositionPsychosocial factorsType 1DiseaseCytokinesChildhoodExposureCurrent understanding
2000
Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4
Herrick C, MacLeod H, Glusac E, Tigelaar R, Bottomly K. Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4. Journal Of Clinical Investigation 2000, 105: 765-775. PMID: 10727445, PMCID: PMC377464, DOI: 10.1172/jci8624.Peer-Reviewed Original ResearchConceptsTh2 responsesIL-13IL-4Th2-type immune responseIL-4-deficient miceTh2-promoting cytokinesOVA-specific IgG1Bronchoalveolar lavage fluidWild-type miceAllergen encounterTh2 sensitizationAirway challengeTh2 activationAllergen exposureAtopic individualsBAL fluidEnvironmental allergensWT miceLavage fluidPrimary exposureVivo depletionAnatomic sitesImmune responseAnimal modelsMice
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