Effect of TNF-α inhibitors on transcriptional levels of pro-inflammatory interleukin-33 and Toll-like receptors-2 and -9 in psoriatic plaques
VAGELI DP, EXARCHOU A, ZAFIRIOU E, DOUKAS PG, DOUKAS S, ROUSSAKI-SCHULZE A. Effect of TNF-α inhibitors on transcriptional levels of pro-inflammatory interleukin-33 and Toll-like receptors-2 and -9 in psoriatic plaques. Experimental And Therapeutic Medicine 2015, 10: 1573-1577. PMID: 26622528, PMCID: PMC4577938, DOI: 10.3892/etm.2015.2688.Peer-Reviewed Original ResearchTLR-2Psoriatic plaquesTNF-α inhibitorsIL-33PASI scoreTLR-9MRNA levelsPsoriasis Area Severity Index (PASI) scoreTNF-α inhibitor treatmentToll-like receptor 2Reverse transcription-quantitative polymerase chain reactionOpen-label studyTranscription-quantitative polymerase chain reactionWeeks of treatmentSeverity Index scorePro-inflammatory moleculesToll-like receptorsIL-1 receptorInnate immune responseElevated IL-33TNF-α treatmentMRNA expression ratioEtanercept groupPlaque psoriasisSignificant positive Pearson correlation
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