2022
VE607 stabilizes SARS-CoV-2 Spike in the “RBD-up” conformation and inhibits viral entry
Ding S, Ullah I, Gong SY, Grover J, Mohammadi M, Chen Y, Vézina D, Beaudoin-Bussières G, Verma VT, Goyette G, Gaudette F, Richard J, Yang D, Smith AB, Pazgier M, Côté M, Abrams C, Kumar P, Mothes W, Uchil P, Finzi A, Baron C. VE607 stabilizes SARS-CoV-2 Spike in the “RBD-up” conformation and inhibits viral entry. IScience 2022, 25: 104528. PMID: 35677392, PMCID: PMC9164512, DOI: 10.1016/j.isci.2022.104528.Peer-Reviewed Original ResearchSARS-CoV-2 infectionAuthentic SARS-CoV-2K18-hACE2 miceS-ACE2 interactionsDevelopment of immunotherapySARS-CoV-2 spikeSARS-CoV-2SARS-CoV-1Prophylactic treatmentLow micromolar concentrationsViral replicationACE2 receptorPseudoviral particlesViral entrySpike glycoproteinPotential targetCOVID-19Drug developmentInfectionACE2 interfaceHost cellsMicromolar concentrationsReceptorsTreatmentRBD
2016
The Dual NOD1/NOD2 Agonism of Muropeptides Containing a Meso-Diaminopimelic Acid Residue
Dagil Y, Arbatsky N, Alkhazova B, L’vov V, Mazurov D, Pashenkov M. The Dual NOD1/NOD2 Agonism of Muropeptides Containing a Meso-Diaminopimelic Acid Residue. PLOS ONE 2016, 11: e0160784. PMID: 27513337, PMCID: PMC4981496, DOI: 10.1371/journal.pone.0160784.Peer-Reviewed Original ResearchConceptsMeso-DAPNucleotide-Binding Oligomerization DomainMeso-diaminopimelic acidGram-negative peptidoglycanFragments of peptidoglycanHEK293T cellsCRISPR/Cas9-mediated knockoutGram-negative bacteriaInnate immune responseActivating nucleotide-binding oligomerization domainOverexpression systemOligomerization domainMuropeptidesActivate NOD1Non-terminal positionNOD1Cell typesNOD2 geneNOD2PeptidoglycanResiduesPeptide chainKnockoutBiological activityMicromolar concentrations
1992
Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity
Chen H, Pellegrini J, Aggarwal S, Lei S, Warach S, Jensen F, Lipton. Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. Journal Of Neuroscience 1992, 12: 4427-4436. PMID: 1432103, PMCID: PMC6576016, DOI: 10.1523/jneurosci.12-11-04427.1992.Peer-Reviewed Original ResearchConceptsNMDA receptor-mediated neurotoxicityMK-801Open channel blockTherapeutic advantageLow micromolar concentrationsNMDA open-channel blockersHypoxic-ischemic brain injuryN-methyl-D-aspartate (NMDA) responsesTherapeutic potentialRetinal ganglion cell neuronsRat stroke modelGanglion cell neuronsLevels of glutamateNMDA receptor stimulationCultures of ratConsiderable therapeutic potentialMechanism of actionOpen channel blockerMicromolar concentrationsClinical entityBrain injuryNMDA antagonistsNMDA receptorsExcessive activationStroke model
1991
Unsaturated phosphatidylcholines inhibit superoxide production in human neutrophils
Yoshida K, Mohsenin V. Unsaturated phosphatidylcholines inhibit superoxide production in human neutrophils. Life Sciences 1991, 49: 1359-1365. PMID: 1656156, DOI: 10.1016/0024-3205(91)90200-u.Peer-Reviewed Original Research
1987
Modulation of neuronal activity in the hippocampus by 5-hydroxytryptamine and 5-hydroxytryptamine1a selective drugs
Peroutka S, Mauk M, Kocsis J. Modulation of neuronal activity in the hippocampus by 5-hydroxytryptamine and 5-hydroxytryptamine1a selective drugs. Neuropharmacology 1987, 26: 139-146. PMID: 2884586, DOI: 10.1016/0028-3908(87)90201-2.Peer-Reviewed Original ResearchConceptsTVX Q 7821Hippocampal slice preparationSlice preparationDose-dependent mannerMicromolar concentrationsApplication of drugsPopulation spikesRadioligand techniquesOH-DPATSchaffer collateralsHippocampal membranesNeuronal activityPyramidal layerKetanserinBaseline levelsBuspironeInitial increaseDPATSelective drugsDrugsField potentialsPhysiological effectsPopulationSimilar affinityBenzisothiazol-3
1980
Potentiation of the cGMP‐induced Guinea pig acrosome reaction by zinc
Santos‐Sacchi J, Gordon M, Williams W. Potentiation of the cGMP‐induced Guinea pig acrosome reaction by zinc. Journal Of Experimental Zoology 1980, 213: 289-291. PMID: 6257821, DOI: 10.1002/jez.1402130217.Peer-Reviewed Original Research
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