2025
Exposure to unpredictable childhood environments is associated with amygdala activation during early extinction in adulthood
Duda J, Keding T, Kribakaran S, Odriozola P, Kitt E, Cohodes E, Zacharek S, McCauley S, Haberman J, Joormann J, Gee D. Exposure to unpredictable childhood environments is associated with amygdala activation during early extinction in adulthood. Developmental Cognitive Neuroscience 2025, 74: 101578. PMID: 40493990, PMCID: PMC12179744, DOI: 10.1016/j.dcn.2025.101578.Peer-Reviewed Original ResearchUnpredictable childhood environmentsChildhood unpredictabilityExtinction learningAmygdala activationChildhood environmentAssociated with amygdala activationBasolateral amygdala activityChildhood trauma exposureSkin conductance responsesCross-species researchThreat cuesTrauma exposureNeural regionsSafety learningEarly adversityHealthy young adultsCurrent anxietyAssociated with activationConductance responsesCaregiving environmentAffective functioningHealthy neurodevelopmentNeural activityTargeted clinical interventionsIn adulthood
2017
Characterising youth with callous–unemotional traits and concurrent anxiety: evidence for a high-risk clinical group
Cecil C, McCrory E, Barker E, Guiney J, Viding E. Characterising youth with callous–unemotional traits and concurrent anxiety: evidence for a high-risk clinical group. European Child & Adolescent Psychiatry 2017, 27: 885-898. PMID: 29222633, PMCID: PMC6013514, DOI: 10.1007/s00787-017-1086-8.Peer-Reviewed Original ResearchConceptsCallous-unemotional traitsTrauma historyHigh callous-unemotional traitsCo-occurring anxietyGreater attachment insecurityLevels of irritabilityHigh-risk youthSevere childhood maltreatmentAttachment insecurityADHD symptomatologyAttachment styleAffective functioningCU traitsPsychological distressAntisocial behaviorCommunity sampleAffective dysregulationHigh anxietyChildhood maltreatmentConcurrent anxietyClinical groupsSubstance useAnxietyPsychiatric symptomatologyYouth
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