Exposure to unpredictable childhood environments is associated with amygdala activation during early extinction in adulthood
Duda J, Keding T, Kribakaran S, Odriozola P, Kitt E, Cohodes E, Zacharek S, McCauley S, Haberman J, Joormann J, Gee D. Exposure to unpredictable childhood environments is associated with amygdala activation during early extinction in adulthood. Developmental Cognitive Neuroscience 2025, 74: 101578. PMID: 40493990, PMCID: PMC12179744, DOI: 10.1016/j.dcn.2025.101578.Peer-Reviewed Original ResearchUnpredictable childhood environmentsChildhood unpredictabilityExtinction learningAmygdala activationChildhood environmentAssociated with amygdala activationBasolateral amygdala activityChildhood trauma exposureSkin conductance responsesCross-species researchThreat cuesTrauma exposureNeural regionsSafety learningEarly adversityHealthy young adultsCurrent anxietyAssociated with activationConductance responsesCaregiving environmentAffective functioningHealthy neurodevelopmentNeural activityTargeted clinical interventionsIn adulthood
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