2020
Choice of P2Y12 inhibitor and clinical outcomes in the AUGUSTUS study: support for an individualised approach
Storey R, Alexander J, Wojdyla D, Mehran R, Vora A, Goodman S, Aronson R, Windecker S, Granger C, Lopes R. Choice of P2Y12 inhibitor and clinical outcomes in the AUGUSTUS study: support for an individualised approach. European Heart Journal 2020, 41: ehaa946.1450. DOI: 10.1093/ehjci/ehaa946.1450.Peer-Reviewed Original ResearchP2Y12 inhibitorsStent thrombosisClinical outcomesPatient's risk of bleedingST ratesTreated with clopidogrelRisk of bleedingDefinite/probable stent thrombosisAspirin cessationCRNM bleedingBleeding riskMedian ageRandomized patientsElective PCIBaseline characteristicsAtrial fibrillationBleeding rateP2Y12TicagrelorIschaemic eventsClopidogrelVKAIndividualised choicePatient riskPatients
2019
Effects of high dose atorvastatin before elective percutaneous coronary intervention on highly sensitive troponin T and one year major cardiovascular events; a randomized clinical trial
Pourhosseini H, Lashkari R, Aminorroaya A, Soltani D, Jalali A, Tajdini M. Effects of high dose atorvastatin before elective percutaneous coronary intervention on highly sensitive troponin T and one year major cardiovascular events; a randomized clinical trial. IJC Heart & Vasculature 2019, 22: 96-101. PMID: 30671535, PMCID: PMC6328087, DOI: 10.1016/j.ijcha.2018.12.003.Peer-Reviewed Original ResearchGroup AGroup BElective PCIPatients of group ACompared to group BAssociated with worse outcomesElective percutaneous coronary interventionHigh dose atorvastatinMedian Follow-UpElevated cardiac enzymesSensitivity troponin THigh-dose treatmentOccurrence of MACEPretreatment of patientsProportional hazards regression modelsMajor cardiovascular eventsHazards regression modelsPercutaneous coronary interventionDose atorvastatinCardiac enzymesDaily dosageStable anginaWorse outcomesCardiovascular eventsFollow-up
2015
Percutaneous Coronary Intervention Utilization and Appropriateness across the United States
Thomas MP, Parzynski CS, Curtis JP, Seth M, Nallamothu BK, Chan PS, Spertus JA, Patel MR, Bradley SM, Gurm HS. Percutaneous Coronary Intervention Utilization and Appropriateness across the United States. PLOS ONE 2015, 10: e0138251. PMID: 26379053, PMCID: PMC4575022, DOI: 10.1371/journal.pone.0138251.Peer-Reviewed Original ResearchConceptsAppropriate use criteriaHospital referral regionsPCI utilizationQuintile 5PCI ratesQuintiles 1PCI appropriatenessPercutaneous coronary intervention useMedicare Limited Data SetRisk-adjusted mortalityNCDR CathPCI RegistryElective PCICathPCI RegistryInappropriate indicationsPatient characteristicsStudy cohortAppropriate indicationsPCI proceduresHeart AssociationCardiovascular AngiographyStudy populationAmerican CollegeReferral regionsSubstantial geographic variationIntervention utilization
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