2023
Acquired Disorders of Hypomagnesemia
Rosner M, Ha N, Palmer B, Perazella M. Acquired Disorders of Hypomagnesemia. Mayo Clinic Proceedings 2023, 98: 581-596. PMID: 36872194, DOI: 10.1016/j.mayocp.2022.12.002.Peer-Reviewed Original ResearchConceptsReduced glomerular filtration rateBody storesBody magnesium storesGlomerular filtration rateSerum magnesium levelsTotal body storesDevelopment of symptomsIntravenous replacementOrgan dysfunctionMagnesium disordersRenal lossMagnesium replacementFiltration rateSevere casesMagnesium storesHypomagnesemiaClinical experienceClinical practiceMagnesium levelsAcquired disordersAmphotericin BMagnesium handlingOptimal managementMedicationsLaboratory assessment
2009
Renal FcRn Reclaims Albumin but Facilitates Elimination of IgG
Sarav M, Wang Y, Hack B, Chang A, Jensen M, Bao L, Quigg R. Renal FcRn Reclaims Albumin but Facilitates Elimination of IgG. Journal Of The American Society Of Nephrology 2009, 20: 1941-1952. PMID: 19661163, PMCID: PMC2736763, DOI: 10.1681/asn.2008090976.Peer-Reviewed Original ResearchConceptsElimination of IgGFcRn(-/-Renal lossFcRn(-/-) miceMinimal urinary excretionSerum albumin levelWild-type miceWild-type kidneysSerum concentrations of albuminProximal tubular epitheliumWild-type controlsDevelopment of hypoalbuminemiaNeonatal Fc receptorLoss of IgGLoss of albuminSerum levelsAlbumin levelsIncreased to wild-type levelsUrinary excretionSerum concentrationsFc receptorsTubular epitheliumConcentrations of albuminPlasma protein poolKidney
2008
A translocation causing increased α-Klotho level results in hypophosphatemic rickets and hyperparathyroidism
Brownstein CA, Adler F, Nelson-Williams C, Iijima J, Li P, Imura A, Nabeshima Y, Reyes-Mugica M, Carpenter TO, Lifton RP. A translocation causing increased α-Klotho level results in hypophosphatemic rickets and hyperparathyroidism. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 3455-3460. PMID: 18308935, PMCID: PMC2265125, DOI: 10.1073/pnas.0712361105.Peer-Reviewed Original ResearchConceptsHypophosphatemic ricketsAlpha-KlothoExcessive renal lossPhosphate levelsParathyroid massRenal failureRenal osteodystrophyFGF23 levelsMajor complicationsParathyroid hyperplasiaKidney failureRenal lossBeta-glucuronidase activityNormal responseHyperparathyroidismEnergy homeostasisRicketsBone formationSkeletal abnormalitiesPhysiologic processesPhosphate homeostasisHyperphosphatemiaPatientsHyperplasiaBone defects
1994
Optimal renal preservation with timely percutaneous intervention: a changing concept in the management of blunt renal trauma in children in the 1990s
GILL B, PALMER L, REDA E, FRANCO I, KOGAN S, LEVITT S. Optimal renal preservation with timely percutaneous intervention: a changing concept in the management of blunt renal trauma in children in the 1990s. BJU International 1994, 74: 370-374. PMID: 7953270, DOI: 10.1111/j.1464-410x.1994.tb16629.x.Peer-Reviewed Original ResearchConceptsBlunt renal traumaGrade II injuriesRenal traumaRenal preservationPercutaneous interventionMajor blunt renal injuriesBlunt renal injuriesMajor blunt injuriesMajor renal lacerationsResults of treatmentRenal lacerationsConservative therapyConservative managementRenal injuryBlunt injuryPercutaneous drainageSignificant morbidityPedicle injurySecondary complicationsGrade IIIRenal lossComplete resolutionPartial nephrectomyTreatment recommendationsGrade I
1981
Adverse effects of liquid protein fast on the handling of magnesium, calcium and phosphorus
Licata A, Lantigua R, Amatruda J, Lockwood D. Adverse effects of liquid protein fast on the handling of magnesium, calcium and phosphorus. The American Journal Of Medicine 1981, 71: 767-772. PMID: 7304647, DOI: 10.1016/0002-9343(81)90362-4.Peer-Reviewed Original ResearchConceptsUrinary lossMagnesium levelsUrinary titratable acid excretionFecal lossSerum bicarbonate levelsSerum calcium levelsTitratable acid excretionMeq of potassiumNegative mineral balanceSkeletal storesMetabolic wardUrinary calciumObese subjectsSerum phosphorusRenal lossUrinary ammoniumDietary intakeHandling of magnesiumExcretion of phosphorusMineral metabolismSerum valuesAcid excretionBicarbonate levelsCalcium levelsLiquid protein
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