2024
Acute Effects of Growth Hormone on the Cellular Immunologic Landscape in Pediatric Patients
Gujral J, Kidd B, Becker C, Golden E, Lee H, Kim-Schulze S, Yau M, Dudley J, Rapaport R. Acute Effects of Growth Hormone on the Cellular Immunologic Landscape in Pediatric Patients. Cureus 2024, 16: e57383. PMID: 38566781, PMCID: PMC10984134, DOI: 10.7759/cureus.57383.Peer-Reviewed Original ResearchTime-of-flight mass cytometryComplete blood countGrowth hormoneImmune systemDendritic cellsPediatric patientsAcute effectsAcute effects of growth hormoneMonocyte countProspective study of pediatric patientsStudy of pediatric patientsMass cytometryEffects of growth hormoneGH stimulation testsComplete blood count analysisAbsolute lymphocyte countWhite blood cell countAbsolute neutrophil countAbsolute monocyte countAbsolute eosinophil countTertiary care centerBlood cell countTotal white blood cell countGH statusGH response
2003
The influence of insulin on circulating ghrelin
Flanagan DE, Evans ML, Monsod TP, Rife F, Heptulla RA, Tamborlane WV, Sherwin RS. The influence of insulin on circulating ghrelin. AJP Endocrinology And Metabolism 2003, 284: e313-e316. PMID: 12531744, DOI: 10.1152/ajpendo.00569.2001.Peer-Reviewed Original ResearchConceptsGhrelin productionGrowth hormone secretagogue receptorSuppression of ghrelinAction of ghrelinHyperglycemic glucose clampInfluence of insulinGhrelin releaseGhrelin levelsGH responseGH secretionGH axisInsulin infusionSecretagogue receptorGlucose clampGhrelinHypoglycemiaEnergy homeostasisPhysiological regulatorSignificant riseInsulinGHNovel peptideAdditional effectClampGlucose
2002
Cortisol modulation of 5-HT-mediated growth hormone release in recovered depressed patients
Bhagwagar Z, Hafizi S, Cowen P. Cortisol modulation of 5-HT-mediated growth hormone release in recovered depressed patients. Journal Of Affective Disorders 2002, 72: 249-255. PMID: 12450642, DOI: 10.1016/s0165-0327(01)00467-0.Peer-Reviewed Original ResearchConceptsGrowth hormone releaseDepressed patientsMajor depressionHormone releaseStress-induced cortisol secretionBrain serotonin functionPlasma GH levelsEffects of cortisolEffect of hydrocortisoneCross-over designStressful life eventsGH responseGH levelsSingle doseCortisol secretionGH releaseHealthy controlsSerotonin functionRecurrent depressionTRP infusionHealthy volunteersCortisol modulationDepressive symptomatologyDepressed subjectsEuthymic subjects
2000
Growth hormone response to clonidine in adversely reared young adult primates: relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations
Coplan J, Smith E, Trost R, Scharf B, Altemus M, Bjornson L, Owens M, Gorman J, Nemeroff C, Rosenblum L. Growth hormone response to clonidine in adversely reared young adult primates: relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations. Psychiatry Research 2000, 95: 93-102. PMID: 10963795, DOI: 10.1016/s0165-1781(00)00173-6.Peer-Reviewed Original ResearchConceptsCSF CRF concentrationsVariable foraging demandGrowth hormone responseGH responseCRF concentrationsCerebrospinal fluid corticotropin-releasing factor concentrationsHormone responseCorticotropin-releasing factor concentrationsAdult primatesDosage of clonidineYoung adult primatesAdrenergic agonist clonidineCorticotropin-releasing factorAgonist clonidineNeuroendocrine abnormalitiesPersistent elevationPrevious primate studiesGH releaseGH-like immunoreactivitySignificant inverse relationshipKetamine anesthesiaClonidineCRF activityHuman patientsFactor concentrations
1998
The Acid-Labile Subunit of Human Ternary Insulin-Like Growth Factor Binding Protein Complex in Serum: Hepatosplanchnic Release, Diurnal Variation, Circulating Concentrations in Healthy Subjects, and Diagnostic Use in Patients with Growth Hormone Deficiency
Juul A, Møller S, Mosfeldt-Laursen E, Rasmussen M, Scheike T, Pedersen S, Kastrup K, Yu H, Mistry J, Rasmussen S, Müller J, Henriksen J, Skakkebæk N. The Acid-Labile Subunit of Human Ternary Insulin-Like Growth Factor Binding Protein Complex in Serum: Hepatosplanchnic Release, Diurnal Variation, Circulating Concentrations in Healthy Subjects, and Diagnostic Use in Patients with Growth Hormone Deficiency. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 4408-4415. PMID: 9851786, DOI: 10.1210/jcem.83.12.5311.Peer-Reviewed Original ResearchConceptsAcid-labile subunitIGFBP-3GH deficiencyALS levelsHepatosplanchnic releaseNormal age-related rangesChildhood-onset GH deficiencyInsulin-like growth factorAge-related rangeSignificant arteriovenous gradientNormal GH responseGH secretory statusConcentrations of IGFLiver vein catheterizationGrowth hormone deficiencyCirculating ConcentrationsGH responseGHD patientsVein catheterizationSecretory statusArteriovenous gradientHormone deficiencyHealthy subjectsDiagnostic utilityIGF
1997
Restoration of detectable melatonin after entrainment to a 24-hour schedule in a ‘free-running’ man
Oren D, Giesen H, Wehr T. Restoration of detectable melatonin after entrainment to a 24-hour schedule in a ‘free-running’ man. Psychoneuroendocrinology 1997, 22: 39-52. PMID: 9141150, DOI: 10.1016/s0306-4530(96)00038-8.Peer-Reviewed Original ResearchConceptsGRF-44Multiple endocrine abnormalitiesInfusion of TRHPineal gland secretionNocturnal melatonin secretionAbnormal endocrine functionCircadian rhythm disordersSleep-wake disordersGH responseThyrotropin levelsEndocrine abnormalitiesCRH infusionEndocrine challengesDifferential diagnosisAbnormal responseGonadal axesEndocrine functionRhythm disordersSerum melatoninGrowth hormoneMelatonin secretionDaily exposureCircadian profileMelatoninLux light
1990
Growth hormone and prolactin response to methylphenidate in children with attention deficit disorder
Shaywitz B, Shaywitz S, Sebrechts M, Anderson G, Cohen D, Jatlow P, Young J. Growth hormone and prolactin response to methylphenidate in children with attention deficit disorder. Life Sciences 1990, 46: 625-633. PMID: 2308471, DOI: 10.1016/0024-3205(90)90131-a.Peer-Reviewed Original Research
1981
Plasma free MHPG and neuroendocrine responses to challenge doses of clonidine in Tourette's Syndrome: Preliminary report
Young J, Cohen D, Hattox S, Kavanagh M, Anderson G, Shaywitz B, Maas J. Plasma free MHPG and neuroendocrine responses to challenge doses of clonidine in Tourette's Syndrome: Preliminary report. Life Sciences 1981, 29: 1467-1475. PMID: 6946271, DOI: 10.1016/0024-3205(81)90012-6.Peer-Reviewed Original ResearchConceptsFree MHPGPlasma free MHPGTourette syndromeChallenge doseNeuroendocrine responsesDoses of clonidineSingle oral dosesClonidine administrationResponsive patientsGH responseOral dosesMaintenance treatmentThyroxine indexClonidineTS patientsPatientsMHPGSyndromeT patientsNeuropsychiatric patientsPilot studyPreliminary reportMetabolic responseFurther investigationDose
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