2024
Mouse Models of Hereditary Xerocytosis-Associated PIEZO1 Mutations Reveal Genotype-Phenotype Differences in Hematological Defects and Iron Loading
Finberg K, Peres Diaz L, Shan P, Chua E, Lalwani K, Gallagher P. Mouse Models of Hereditary Xerocytosis-Associated PIEZO1 Mutations Reveal Genotype-Phenotype Differences in Hematological Defects and Iron Loading. Blood 2024, 144: 3851-3851. DOI: 10.1182/blood-2024-203740.Peer-Reviewed Original ResearchRed cell distribution widthHereditary xerocytosisSpleen weight/body weight ratioRed blood cell countMean corpuscular volumeCompared to wild-typeHematological defectsMouse modelHeart weight/body weight ratioWild-typeIron loadingComplete blood count analysisRed blood cell turnoverSerum transferrin saturationC57BL/6 genetic backgroundSerum hepcidin levelsLiver iron loadingYoung adult miceGenotype-phenotype differencesCell distribution widthMean corpuscular hemoglobinGain-of-function mutationsBlood count analysisNon-heme iron concentrationsRed cell indicesAcute Effects of Growth Hormone on the Cellular Immunologic Landscape in Pediatric Patients
Gujral J, Kidd B, Becker C, Golden E, Lee H, Kim-Schulze S, Yau M, Dudley J, Rapaport R. Acute Effects of Growth Hormone on the Cellular Immunologic Landscape in Pediatric Patients. Cureus 2024, 16: e57383. PMID: 38566781, PMCID: PMC10984134, DOI: 10.7759/cureus.57383.Peer-Reviewed Original ResearchTime-of-flight mass cytometryComplete blood countGrowth hormoneImmune systemDendritic cellsPediatric patientsAcute effectsAcute effects of growth hormoneMonocyte countProspective study of pediatric patientsStudy of pediatric patientsMass cytometryEffects of growth hormoneGH stimulation testsComplete blood count analysisAbsolute lymphocyte countWhite blood cell countAbsolute neutrophil countAbsolute monocyte countAbsolute eosinophil countTertiary care centerBlood cell countTotal white blood cell countGH statusGH response
2022
Toxicity Assessment of Mesoporous Silica Nanoparticles upon Intravenous Injection in Mice: Implications for Drug Delivery
MacCuaig W, Samykutty A, Foote J, Luo W, Filatenkov A, Li M, Houchen C, Grizzle W, McNally L. Toxicity Assessment of Mesoporous Silica Nanoparticles upon Intravenous Injection in Mice: Implications for Drug Delivery. Pharmaceutics 2022, 14: 969. PMID: 35631554, PMCID: PMC9148138, DOI: 10.3390/pharmaceutics14050969.Peer-Reviewed Original ResearchPre-existing lesionsIntravenous injectionChronic injectionsTreatment groupsBlood chemistryComplete blood count analysisStandard blood chemistryBlood count analysisMultiple intravenous injectionsModerate exacerbationsAdministered treatmentVascular conditionsMinor exacerbationsVital organsFurther evaluationTreatment of diseasesMinimal toxicityTranslational potentialNano-delivery systemsExacerbationFurther studiesInjectionLesionsMiceVivo toxicity
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