2010
Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: A pilot study
Coplan JD, Abdallah CG, Kaufman J, Gelernter J, Smith EL, Perera TD, Dwork AJ, Kaffman A, Gorman JM, Rosenblum LA, Owens MJ, Nemeroff CB. Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: A pilot study. Psychoneuroendocrinology 2010, 36: 289-293. PMID: 20692103, PMCID: PMC3017732, DOI: 10.1016/j.psyneuen.2010.07.011.Peer-Reviewed Original ResearchConceptsEarly life stressCSF CRF concentrationsCRF concentrationsCerebrospinal fluid corticotropin-releasing factor concentrationsCorticotropin-releasing factor concentrationsPilot studyNonhuman primate modelCorticotropin-releasing factorYears of ageEarly life adversitySerotonin transporter gene polymorphismPersistent elevationTransporter gene polymorphismPrimate modelMajor depressionCSF samplesDepressive symptomsGene polymorphismsAllele groupFactor concentrationsLFD conditionsMale bonnet macaquesChildhood abuseSubsequent developmentBonnet macaques
2001
Variable foraging demand rearing: sustained elevations in cisternal cerebrospinal fluid corticotropin-releasing factor concentrations in adult primates
Coplan J, Smith E, Altemus M, Scharf B, Owens M, Nemeroff C, Gorman J, Rosenblum L. Variable foraging demand rearing: sustained elevations in cisternal cerebrospinal fluid corticotropin-releasing factor concentrations in adult primates. Biological Psychiatry 2001, 50: 200-204. PMID: 11513819, DOI: 10.1016/s0006-3223(01)01175-1.Peer-Reviewed Original ResearchConceptsCerebrospinal fluid corticotropin-releasing factor concentrationsCorticotropin-releasing factor concentrationsFactor concentrationsCSF CRFAdult primatesYoung adult primatesYoung adulthoodCisternal CSF samplesCSF samplesCRF functionControl groupCRF valuesSignificant positive correlationAd libitumPresent studyJuvenile primatesPositive correlationAdulthoodPrimatesCRFElevation
2000
Growth hormone response to clonidine in adversely reared young adult primates: relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations
Coplan J, Smith E, Trost R, Scharf B, Altemus M, Bjornson L, Owens M, Gorman J, Nemeroff C, Rosenblum L. Growth hormone response to clonidine in adversely reared young adult primates: relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations. Psychiatry Research 2000, 95: 93-102. PMID: 10963795, DOI: 10.1016/s0165-1781(00)00173-6.Peer-Reviewed Original ResearchConceptsCSF CRF concentrationsVariable foraging demandGrowth hormone responseGH responseCRF concentrationsCerebrospinal fluid corticotropin-releasing factor concentrationsHormone responseCorticotropin-releasing factor concentrationsAdult primatesDosage of clonidineYoung adult primatesAdrenergic agonist clonidineCorticotropin-releasing factorAgonist clonidineNeuroendocrine abnormalitiesPersistent elevationPrevious primate studiesGH releaseGH-like immunoreactivitySignificant inverse relationshipKetamine anesthesiaClonidineCRF activityHuman patientsFactor concentrations
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