2015
Origin of fibrosing cells in systemic sclerosis
Ebmeier S, Horsley V. Origin of fibrosing cells in systemic sclerosis. Current Opinion In Rheumatology 2015, 27: 555-562. PMID: 26352735, PMCID: PMC4639394, DOI: 10.1097/bor.0000000000000217.Peer-Reviewed Original ResearchConceptsSystemic sclerosisEndothelial cellsInjury-induced fibrosisEpithelial cellsProgressive fibrosisAutoimmune diseasesTreatment optionsEffective therapyInjury modelFibrosis modelChronic natureAnimal modelsTissue stromaSclerosisCell originFibrosisUnknown originVariety of tissuesCellular originRecent evidenceFibrocytesDiseasePericytesSpecific organsAdipocytes
2009
Gadolinium‐containing magnetic resonance image contrast agent promotes fibrocyte differentiation
Vakil V, Sung JJ, Piecychna M, Crawford JR, Kuo P, Abu‐Alfa A, Cowper SE, Bucala R, Gomer RH. Gadolinium‐containing magnetic resonance image contrast agent promotes fibrocyte differentiation. Journal Of Magnetic Resonance Imaging 2009, 30: 1284-1288. PMID: 19937928, PMCID: PMC2787835, DOI: 10.1002/jmri.21800.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsNephrogenic systemic fibrosisSerum amyloid PFibrocyte differentiationDifferentiation of monocytesNSF patientsBlood mononuclear cellsHemodialysis patientsInterleukin-12Mononuclear cellsPurified monocytesFibroblast-like cellsFibrotic lesionsHealthy controlsSystemic fibrosisAmyloid PContrast agentsPatientsMonocytesDifferentiation inhibitorWiley-LissFibrocytesOmniscanDifferentiation protocolsCells
2007
Culture and Analysis of Circulating Fibrocytes
Quan TE, Bucala R. Culture and Analysis of Circulating Fibrocytes. Methods In Molecular Medicine 2007, 135: 423-434. PMID: 17951676, DOI: 10.1007/978-1-59745-401-8_28.Peer-Reviewed Original ResearchConceptsPeripheral bloodDifferent mammalian speciesMammalian speciesMatrix proteinsHematopoetic originPeripheral blood fibrocytesCultured cellsFlow cytometry analysisUnique surface phenotypeCell surface markersModel systemCirculating FibrocytesWound repairCytometry analysisBlood fibrocytesMononuclear cellsSurface phenotypeWound chambersGrowth characteristicsCellsBuffy coatFibrocytesSurface markersBloodSpecies
2006
Nephrogenic systemic fibrosis (nephrogenic fibrosing dermopathy)
Galan A, Cowper SE, Bucala R. Nephrogenic systemic fibrosis (nephrogenic fibrosing dermopathy). Current Opinion In Rheumatology 2006, 18: 614-617. PMID: 17053507, DOI: 10.1097/01.bor.0000245725.94887.8d.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNephrogenic systemic fibrosisSystemic fibrosisNephrogenic fibrosing dermopathyRenal insufficiencyClinical awarenessSystemic diseaseClinical spectrumTreatment optionsFibrogenic factorsEffective therapyFatal disorderEnigmatic disorderClinical reportsCardinal featuresFibrosisSpecific causesDisordersPathogenesisFibrocytesFuture studiesCauseRheumatologistsPatientsEtiopathogenesisRegistryThe role of circulating fibrocytes in fibrosis
Quan TE, Cowper SE, Bucala R. The role of circulating fibrocytes in fibrosis. Current Rheumatology Reports 2006, 8: 145-150. PMID: 16569374, DOI: 10.1007/s11926-006-0055-x.Peer-Reviewed Original ResearchConceptsPulmonary fibrosisFunctions of fibrocytesAreas of inflammationSerum amyloid PTissue repair responseFibrocyte traffickingInflammatory cytokinesPeripheral bloodMalignant potentialFibrotic lesionsStromal responseIL-1Skin lesionsPathologic fibrosisNew therapiesAmyloid PHypertrophic scarsTissue damageMatrix metalloproteinasesFibrosisRemodeling responseTumor invasionFibrocytesContractile myofibroblastsExperimental model
2004
Circulating fibrocytes: collagen-secreting cells of the peripheral blood
Quan TE, Cowper S, Wu SP, Bockenstedt LK, Bucala R. Circulating fibrocytes: collagen-secreting cells of the peripheral blood. The International Journal Of Biochemistry & Cell Biology 2004, 36: 598-606. PMID: 15010326, DOI: 10.1016/j.biocel.2003.10.005.Peer-Reviewed Original ResearchConceptsNephrogenic fibrosing dermopathyAntigen-presenting cellsNaïve T cellsNew disease entityPresentation of antigensImportant etiopathogenic roleRenal insufficiencyUnique cell populationFibrosing disorderLocal tissue environmentImmunological markersInflammatory cytokinesPeripheral bloodEtiopathogenic roleFibrotic lesionsGranuloma formationAntigen presentationDisease entityT cellsHypertrophic scarsMatrix metalloproteinasesRemodeling responseFibrocytesContractile myofibroblastsCollagen-secreting cells
2000
Peripheral blood fibrocytes: Mesenchymal precursor cells and the pathogenesis of fibrosis
Chesney J, Bucala R. Peripheral blood fibrocytes: Mesenchymal precursor cells and the pathogenesis of fibrosis. Current Rheumatology Reports 2000, 2: 501-505. PMID: 11123104, DOI: 10.1007/s11926-000-0027-5.Peer-Reviewed Original ResearchConceptsPeripheral blood fibrocytesBlood fibrocytesTissue injuryDistinct cell surface phenotypePersistent T-cell activationNaïve T cellsPathogenesis of fibrosisCell surface phenotypeT cell activationCognate immunityAutoimmune disordersConnective tissue cellsImmunohistochemical studyForeign antigensT cellsSurface phenotypeMesenchymal precursor cellsScar formationFibrotic tissueFibrocytesGrowth factorPrecursor cellsNovel populationMatrix depositionInjuryMacaque blood‐derived antigen‐presenting cells elicit SIV‐specific immune responses
Zhu Y, Koo K, Bradshaw J, Sutton W, Kuller L, Bucala R, Anderson D, Mossman S, Villinger F, Haigwood N. Macaque blood‐derived antigen‐presenting cells elicit SIV‐specific immune responses. Journal Of Medical Primatology 2000, 29: 182-192. PMID: 11085581, DOI: 10.1034/j.1600-0684.2000.290312.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibody FormationAntigen-Presenting CellsAntigens, CDAntigens, CD34Antigens, ViralCells, CulturedDendritic CellsGenes, ReporterGreen Fluorescent ProteinsHumansImmunity, CellularImmunoglobulinsLuminescent ProteinsMacaca fascicularisMembrane GlycoproteinsMonocytesSAIDS VaccinesSimian Acquired Immunodeficiency SyndromeSimian immunodeficiency virusTransfectionTransplantation, AutologousConceptsMonocyte-derived dendritic cellsDendritic cellsAntigen-presenting cellsInterleukin-4Autologous monocyte-derived dendritic cellsSIV-specific immune responsesAutologous dendritic cellsDC marker CD83Macaque dendritic cellsGranulocyte-macrophage colonyMurine fibrocytesSIV vaccinesSIV antigensHumoral responseAntigen presentationImmune responseCharacteristic cellular morphologyDNA expression vectorsFibrocytesMacaca fascicularisSIVProtein expression plasmidsMacaquesExpression plasmidCells
1999
Interaction of Borrelia burgdorferi with Peripheral Blood Fibrocytes, Antigen-Presenting Cells with the Potential for Connective Tissue Targeting
Grab D, Lanners H, Martin L, Chesney J, Cai C, Adkisson H, Bucala R. Interaction of Borrelia burgdorferi with Peripheral Blood Fibrocytes, Antigen-Presenting Cells with the Potential for Connective Tissue Targeting. Molecular Medicine 1999, 5: 46-54. PMID: 10072447, PMCID: PMC2230375, DOI: 10.1007/bf03402138.Peer-Reviewed Original ResearchConceptsPeripheral blood fibrocytesBlood fibrocytesDifferent cell typesB. burgdorferiB. burgdorferi bindsInteraction of BorreliaMolecular mechanismsOspB proteinsAntigen presenting cellsCell typesFibroblast-like cellsCellular interactionsCell membraneJoint connective tissuesCollagen type ILyme arthritisPresent antigensInflammatory processT cellsFunctional capacityCellular collagenImmune systemFlow cytometryFibrocytesConnective tissue
1994
Circulating Fibrocytes Define a New Leukocyte Subpopulation That Mediates Tissue Repair
Bucala R, Spiegel L, Chesney J, Hogan M, Cerami A. Circulating Fibrocytes Define a New Leukocyte Subpopulation That Mediates Tissue Repair. Molecular Medicine 1994, 1: 71-81. PMID: 8790603, PMCID: PMC2229929, DOI: 10.1007/bf03403533.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBone MarrowBone Marrow CellsCD4 AntigensCell AdhesionCells, CulturedCentrifugationChimeraCollagenConnective TissueCytoskeletonDNA-Binding ProteinsDose-Response Relationship, RadiationFemaleFibroblastsFlow CytometryFluorescent Antibody TechniqueHumansImmunohistochemistryLeukocytesMaleMiceMice, Inbred BALB CMicroscopy, ElectronMolecular Sequence DataNuclear ProteinsPhenotypeSex-Determining Region Y ProteinTime FactorsTranscription FactorsTransplantation, HeterologousVimentinWound HealingConceptsTissue injuryLeukocyte subpopulationsScar formationLong-term remodelingFibroblast-like propertiesNormal wound repairConnective tissue scarConnective tissue elementsCell typesFibrotic responseTissue scarWound chambersPathological fibrotic responsesHost responseInjuryConnective tissueFibrocytesWound repairFibroblast propertiesTissue repairTissue elementsDistinctive phenotypeSubpopulationsTissueNovel cell types
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