2019
The challenges of primary biliary cholangitis: What is new and what needs to be done
Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D, Vierling JM, Adams D, Alpini G, Banales JM, Beuers U, Björnsson E, Bowlus C, Carbone M, Chazouillères O, Dalekos G, De Gottardi A, Harada K, Hirschfield G, Invernizzi P, Jones D, Krawitt E, Lanzavecchia A, Lian ZX, Ma X, Manns M, Mavilio D, Quigley EM, Sallusto F, Shimoda S, Strazzabosco M, Swain M, Tanaka A, Trauner M, Tsuneyama K, Zigmond E, Gershwin ME. The challenges of primary biliary cholangitis: What is new and what needs to be done. Journal Of Autoimmunity 2019, 105: 102328. PMID: 31548157, DOI: 10.1016/j.jaut.2019.102328.Peer-Reviewed Original ResearchConceptsPrimary biliary cholangitisAnti-mitochondrial autoantibodiesBiochemical cholestasisBiliary cholangitisBiliary epitheliumUrsodeoxycholic acidPBC-specific anti-nuclear antibodiesBile acidsToxic hydrophobic bile acidsAutoimmune liver diseaseSecond-line treatmentFirst-line treatmentAnti-nuclear antibodiesReliable disease markersEarly disease stagesCholestatic biochemical profileNew therapeutic approachesHydrophobic bile acidsAutoimmune originSeronegative casesLiver histologyAutoimmune attackFemale preponderanceHistologic confirmationImmunologic pathways
2017
Microbiota control immune regulation in humanized mice
Gülden E, Vudattu NK, Deng S, Preston-Hurlburt P, Mamula M, Reed JC, Mohandas S, Herold BC, Torres R, Vieira SM, Lim B, Herazo-Maya JD, Kriegel M, Goodman AL, Cotsapas C, Herold KC. Microbiota control immune regulation in humanized mice. JCI Insight 2017, 2: e91709. PMID: 29093268, PMCID: PMC5752290, DOI: 10.1172/jci.insight.91709.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAnimalsAntibodies, AntinuclearAntibodies, Monoclonal, HumanizedAutoimmune DiseasesB7-2 AntigenCD11b AntigenCD11c AntigenCD3 ComplexCD8-Positive T-LymphocytesCytokinesDisease Models, AnimalGastrointestinal MicrobiomeGastrointestinal TractGraft RejectionHumansImmunosuppressive AgentsImmunotherapyInterferon-gammaInterleukin-10Interleukin-27Leukocytes, MononuclearMiceMice, KnockoutMucous MembraneSkin TransplantationSTAT5 Transcription FactorT-LymphocytesTransplantation, HeterologousConceptsT cellsIL-10Humanized miceHuman peripheral blood mononuclear cellsPeripheral blood mononuclear cellsIL-27 expressionIL-10 levelsAnti-nuclear antibodiesEffector T cellsLevels of IFNCentral memory cellsLess IL-10Markers of efficacyBlood mononuclear cellsExpression of CD86Immune regulatory pathwaysIL-10 inductionHuman immune cellsHuman stool samplesImmunosuppressive medicationsIL-27Xenograft rejectionImmune therapyMononuclear cellsAntibiotic treatment
2016
Role of the transcription factor Ikaros in development of autoimmune disease
Schjerven H, Frietze S, Hai S, Hermiston M, Kogan S, Muschen M. Role of the transcription factor Ikaros in development of autoimmune disease. The Journal Of Immunology 2016, 196: 47.14-47.14. DOI: 10.4049/jimmunol.196.supp.47.14.Peer-Reviewed Original ResearchAnti-nuclear antibodiesAutoimmune diseasesB cellsB cell developmentSerum anti-nuclear antibodiesAuto-reactive B cellsReactive B cellsEx vivo analysisSpleen B cellsEx vivo studySecond signalBCR stimulationEarly B cell developmentRecent genome-wide association studiesVivo analysisMouse modelGenetic predispositionIkaros mutant miceTranscription factor IkarosMouse strainsDiseaseVivo studiesTargeted deletionZinc finger 1Autoimmunity
2015
Circadian Clock Protein CRY Controls B-Cell Intrinsic Tolerance
Cao Q, Zhao X, Gery S, Chen Z, Deng R, Sun H, Lin D, Zhao Z, Said J, Li Q, Muschen M, Evans R, Koeffler H. Circadian Clock Protein CRY Controls B-Cell Intrinsic Tolerance. Blood 2015, 126: 1029. DOI: 10.1182/blood.v126.23.1029.1029.Peer-Reviewed Original ResearchB cell toleranceDKO miceB cellsRheumatoid arthritisMultiple sclerosisWT miceCell toleranceSerum anti-nuclear antibodiesHigher serum IgG concentrationsMature recirculating B cellsPeripheral B cell toleranceAnti-nuclear antibodiesPre-B cell numbersWild-type miceSerum IgG concentrationB2 B cellsRecirculating B cellsAdaptive immune systemSplenic B cellsImmune toleranceSevere autoimmunitySjögren's syndromeAutoimmune disordersMassive infiltrationComplement 3
2014
Aberant expansion of CXCR5+ memory CD4 T cells in SLE patients (HUM7P.307)
Choi J, Kim S, Kang I, Craft J. Aberant expansion of CXCR5+ memory CD4 T cells in SLE patients (HUM7P.307). The Journal Of Immunology 2014, 192: 184.16-184.16. DOI: 10.4049/jimmunol.192.supp.184.16.Peer-Reviewed Original ResearchCD4 T cellsSLE patientsT cellsTfh cellsB cellsB collaborationB cell helper functionFollicular helper T cellsMemory CD4 T cellsMemory Tfh cellsTh17-like subsetsAnti-nuclear antibodiesHelper T cellsB cell responsesHuman lupus patientsSecondary lymphoid organsMemory B cellsAutoreactive B cellsSuch cellsDistinct Th1Autoantibody titersDisease activityLupus patientsIL-21Lymphoid organs
2008
Prevalence and patterns of anti‐nuclear antibodies in Korean children with juvenile idiopathic arthritis according to ILAR criteria
Shin J, Kim K, Chun J, Lee T, Kim K, Kim H, Kim D. Prevalence and patterns of anti‐nuclear antibodies in Korean children with juvenile idiopathic arthritis according to ILAR criteria. Scandinavian Journal Of Rheumatology 2008, 37: 348-351. PMID: 18666025, DOI: 10.1080/03009740801998762.Peer-Reviewed Original ResearchConceptsAnti-nuclear antibodiesAnti-nuclear antibody titreElevated erythrocyte sedimentation ratePatterns of anti-nuclear antibodiesJuvenile idiopathic arthritisDisease activityFollow-upPersistently elevated erythrocyte sedimentation rateAnti-nuclear antibody testIdiopathic arthritisMarkers of disease activitySubtypes of juvenile idiopathic arthritisAssociated with female sexPattern of immunofluorescence stainingNegative HLA-B27Erythrocyte sedimentation rateInternational League of AssociationsIndirect immunofluorescence methodHEp-2 cellsNuclear fluorescence patternMedian ageDisease remissionANA titresClinical outcomesKorean patients
2002
A Case of Bronchus-Associated Lymphoid Tissue(BALT) Lymphoma in the Lung of the Patient with Primary Sjogren's Syndrome
Kang M, Lee J, Lee S, Son J, Kim D, Lee M, Hyun I, Jung K. A Case of Bronchus-Associated Lymphoid Tissue(BALT) Lymphoma in the Lung of the Patient with Primary Sjogren's Syndrome. Tuberculosis And Respiratory Diseases 2002, 52: 179-185. DOI: 10.4046/trd.2002.52.2.179.Peer-Reviewed Original ResearchPrimary Sjogren's syndromeSjogren's syndromeOpen lung biopsy specimenB-cell lymphoma originatingThin-section CT scansCD 20 antigenAnti-nuclear antibodiesWhole lung fieldMalignant lymphoma cellsBALT lymphomaInspiratory cracklesReticulonodular densitiesDry mouthExertional dyspneaLymphoma originatingDry eyeHistological diagnosisHistological findingsLung zonesPhysical examinationBasal lungBiopsy specimenBronchiolar epitheliumChest radiographsLung fields
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