2025
Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Ethical, Regulatory, and Socioeconomic Dimensions of Theranostic Digital Twins
Strigari L, Schwarz J, Bradshaw T, Brosch-Lenz J, Currie G, El-Fakhri G, Jha A, Mežinska S, Pandit-Taskar N, Roncali E, Shi K, Uribe C, Yusufaly T, Zaidi H, Rahmim A, Saboury B. Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Ethical, Regulatory, and Socioeconomic Dimensions of Theranostic Digital Twins. Journal Of Nuclear Medicine 2025, 66: jnumed.124.268186. PMID: 39848769, PMCID: PMC12051771, DOI: 10.2967/jnumed.124.268186.Peer-Reviewed Original ResearchRadiopharmaceutical therapyNuclear oncologySociety of Nuclear MedicinePredictive dosimetryDosimetric informationTreatment planningTreatment outcomesLack of reimbursementTreatment personalizationDose responseTreatment optimizationEtiological mechanismsRobust security measuresPatient consentReal-world systemsNuclear medicineCross-border data sharingPatientsTreatmentEthical approval
2024
Association of gestational weight gain rate with infant birth weight and cesarean delivery: A prospective cohort study in Nepal
Nepal J, Chaudhary K, Adhikari B, Shrestha A, Shrestha A, Kapri S, Rawal S. Association of gestational weight gain rate with infant birth weight and cesarean delivery: A prospective cohort study in Nepal. PLOS Global Public Health 2024, 4: e0003546. PMID: 39527584, PMCID: PMC11554211, DOI: 10.1371/journal.pgph.0003546.Peer-Reviewed Original ResearchGestational weight gainGestational weight gain rateBody mass indexInfant birth weightCesarean deliveryBirth weightInstitute of Medicine reportGestational weight gain recommendationsPre-pregnancy body mass indexExcessive GWG rateProspective cohort studyPeri-urban hospitalLow birth weightLow-income countriesMedicine reportEthical approvalPre-pregnancyWeight gainCohort studyAverage birth weightMass indexProspective cohortDelivery modeNeonatal outcomesInstitutional review boardEvaluation of Self-vision Assessment Charts in Schools of Eastern Nepal: A Multi Method Study
Shrestha A, Thakur S, Roshan A, Singh S, Pokhrel A, Bohara A, Poudel L, Thakur C, Adhikari A, Timsina P, Acharya Y, Karn R. Evaluation of Self-vision Assessment Charts in Schools of Eastern Nepal: A Multi Method Study. Journal Of Nepal Medical Association 2024, 62: 725-733. PMCID: PMC11931339, DOI: 10.31729/jnma.8796.Peer-Reviewed Original ResearchMulti-method studyEye care programsAssessment chartIn-depth interviewsFramework analysisEastern NepalCare programImprove healthInformation sessionsEthical approvalQuantitative dataParticipants' experiencesMethods studyQuestionnaire surveyVision assessmentChart useHealth expertsPerceived impactExpressed satisfactionHome remediesEye issuesRegular useQualitative dataVision impairmentInstitutional review boardPost-traumatic stress disorder symptoms following exposure to acute psychological trauma in children aged 8–16 years in South Africa: protocol for the Sinethemba longitudinal study
Sharp T, Chideya Y, Giuliani A, Hunt X, Tomlinson M, Seedat S, Creswell C, Fearon P, Hamilton-Giachritsis C, Hiller R, Meiser-Stedman R, Du Toit S, Stewart J, Halligan S. Post-traumatic stress disorder symptoms following exposure to acute psychological trauma in children aged 8–16 years in South Africa: protocol for the Sinethemba longitudinal study. BMJ Open 2024, 14: e085129. PMID: 38991675, PMCID: PMC11624694, DOI: 10.1136/bmjopen-2024-085129.Peer-Reviewed Original ResearchConceptsMental health outcomesPost-traumatic stress disorderChildren aged 8Caregiver supportHealth outcomesAssociation of psychosocial factorsAdverse mental health outcomesAged 8Traumatic eventsChildren’s post-traumatic stress disorderDepartment of HealthMiddle-income countriesTrauma-related mental healthPsychological risk factorsHigh-income countriesStress disorder symptomsFollow-up assessmentPost-traumatic stress disorder symptomsCape TownMotor vehicle accidentsHealthcare clinicsPsychosocial factorsMental healthPsychological recoveryEthical approvalEnhancing emotion regulation with an in situ socially assistive robot among LGBTQ+ youth with self-harm ideation: protocol for a randomised controlled trial
Williams A, Cleare S, Borschmann R, Tench C, Gross J, Hollis C, Chapman-Nisar A, Naeche N, Townsend E, Slovak P, Youth O, Creswell C, Fonagy P, Arseneault L, Lloyd E, De Alcantara Mendes J, Holter C, Jirotka M, Lazar Z, Patalay P, Kelly Y, Kandola A, Sonuga-Barke E, Livingstone S, Kostryka-Allchorne K, Bourgaize J, Stoilova M, O’Connor R, Auer D, Lee S, Jawahar N, Etherson M, Greenhalgh C, Sayal K, Warren J, Wanniarachchi V, Glover K, Stallard P, Hall C, Lucassen M, Merry S, Stasiak K, Babbage C, Khan K, Parker A, Lockwood J, Gregory J, Nielsen E, Vallejos E, Woodcock R, Doherty S, Willingham L. Enhancing emotion regulation with an in situ socially assistive robot among LGBTQ+ youth with self-harm ideation: protocol for a randomised controlled trial. BMJ Open 2024, 14: e079801. PMID: 38195171, PMCID: PMC10806609, DOI: 10.1136/bmjopen-2023-079801.Peer-Reviewed Original ResearchConceptsSelf-harm ideationSelf-harmEmotion dysregulationEmotion regulationRandomised controlled trialsWaitlist controlEnhance emotion regulationExperiences of self-harmSocially assistive robotsSelf-Harm QuestionnaireSelf-harm thoughtsControlled TrialsPeer-reviewed open access journalsLGBTQ+ youthPeople’s own viewsAssistive robotsControl participantsIntervention participantsAcceptable interventionSemistructured interviewsLinear mixed modelsPreliminary evidenceEthical approvalKing's College LondonSecondary outcomes
2023
How do smoking, vaping, and nicotine affect people with epilepsy and seizures? A scoping review protocol
Narrett J, Khan W, Funaro M, Moeller J. How do smoking, vaping, and nicotine affect people with epilepsy and seizures? A scoping review protocol. PLOS ONE 2023, 18: e0288120. PMID: 37418386, PMCID: PMC10328254, DOI: 10.1371/journal.pone.0288120.Peer-Reviewed Original ResearchConceptsSmoking cessationTobacco useReview protocolBurden of comorbiditiesType of epilepsyJoanna Briggs Institute ManualPopulation of personsPeer-reviewed journalsSeizure frequencyNicotine replacementControl seizuresPreventable deathsSide effectsSmokingEthical approvalEpilepsyHealth outcomesPrevalent diseaseSeizuresPersonalized careDirect further researchEvidence synthesisMajor causeSystematic screeningAPA PsycInfoCSF‐Targeted Proteomics Indicate Amyloid‐Beta Ratios in Patients with Alzheimer’s Dementia Spectrum
Behzad M, Zirak N, Madani G, Baidoo L, Rezaei A, Karbasi S, Sadeghi M, Shafie M, Mayeli M, Initiative A. CSF‐Targeted Proteomics Indicate Amyloid‐Beta Ratios in Patients with Alzheimer’s Dementia Spectrum. International Journal Of Alzheimer's Disease 2023, 2023: 5336273. PMID: 36793451, PMCID: PMC9925239, DOI: 10.1155/2023/5336273.Peer-Reviewed Original ResearchAlzheimer's Disease Assessment ScaleMild cognitive impairmentClinical Dementia RatingMini Mental State ExamCognitive scoresAlzheimer's diseaseEarly stages of Alzheimer's diseaseMild cognitive impairment groupAssociated with clinical dementia ratingDisease Assessment ScaleStages of Alzheimer's diseaseMental State ExamCognitive AssessmentCognitive impairmentCognitive declineState ExamDementia spectrumDementia RatingAD spectrumGroup of peptidesAssessment ScaleProteomics researchCerebrospinal fluidEthical approvalADAS-13Scoping review protocol of multicomponent interventions to address cardiometabolic disease risk among Pacific Islander children
Choy C, Nyhan K, Savusa K, Soti-Ulberg C, Rosen R, Naseri T, Hawley N, Sharifi M. Scoping review protocol of multicomponent interventions to address cardiometabolic disease risk among Pacific Islander children. PLOS ONE 2023, 18: e0280888. PMID: 36689458, PMCID: PMC9870166, DOI: 10.1371/journal.pone.0280888.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPacific Islander childrenCMD risk factorsMulticomponent interventionRisk factorsCardiometabolic disease risk factorsDisease risk factorsCardiometabolic disease riskClinical trial registrationPreferred Reporting ItemsJoanna Briggs Institute ManualFormal ethical approvalTRIAL REGISTRATIONCochrane LibraryHigh prevalenceEligible interventionsStudy populationEthical approvalReporting ItemsCMD riskDisease riskIntervention componentsProQuest DissertationsReview protocolEvidence mappingEvidence synthesis
2022
Protocol for the development of SPIRIT and CONSORT extensions for randomised controlled trials with surrogate primary endpoints: SPIRIT-SURROGATE and CONSORT-SURROGATE
Manyara AM, Davies P, Stewart D, Weir CJ, Young A, Butcher NJ, Bujkiewicz S, Chan AW, Collins GS, Dawoud D, Offringa M, Ouwens M, Ross JS, Taylor RS, Ciani O. Protocol for the development of SPIRIT and CONSORT extensions for randomised controlled trials with surrogate primary endpoints: SPIRIT-SURROGATE and CONSORT-SURROGATE. BMJ Open 2022, 12: e064304. PMID: 36220321, PMCID: PMC9557267, DOI: 10.1136/bmjopen-2022-064304.Peer-Reviewed Original ResearchConceptsSurrogate endpointsPeer-reviewed publicationsSurrogate primary endpointOpen-access peer-reviewed publicationPATIENTS/PARTICIPANTSCompleteness of reportingTranslation of effectsPhase 1Primary endpointPrimary outcomeTrial findingsEthical approvalCONSORT extensionSuch trialsEthics CommitteeEndpointHealth benefitsTrialsPhase 3Final outcomePhase 2Transparent reportingOutcomesPhase 4Additional itemsOnline randomised factorial trial of electronic Screening and Brief Intervention for alcohol use in pregnancy: a study protocol
Ondersma SJ, Todd L, Jablonski S, Ahuja C, Gilstad-Hayden K, Goyert G, Loree A, Heffner J, Yonkers KA. Online randomised factorial trial of electronic Screening and Brief Intervention for alcohol use in pregnancy: a study protocol. BMJ Open 2022, 12: e062735. PMID: 35922101, PMCID: PMC9352990, DOI: 10.1136/bmjopen-2022-062735.Peer-Reviewed Original ResearchConceptsPregnant womenBrief interventionAlcohol useFactorial trialHealth Institutional Review BoardAdverse perinatal outcomesFetal alcohol spectrum disordersUnhealthy alcohol useDose-response effectPrenatal alcohol exposureSpectrum of conditionsAlcohol spectrum disordersInstitutional review boardText messagingPeer-reviewed journalsPerinatal outcomesWeeks' gestationBirth outcomesPossible additional benefitsStudy protocolAlcohol exposureAlcohol abstinenceBooster sessionsEthical approvalPrimary analysisEarly integrated palliative care in patients newly diagnosed with cancer in Ethiopia: a randomised controlled trial and cost–consequence analysis
Reid E, Abathun E, Diribi J, Mamo Y, Wondemagegnhu T, Hall P, Fallon M, Grant L. Early integrated palliative care in patients newly diagnosed with cancer in Ethiopia: a randomised controlled trial and cost–consequence analysis. The Lancet Global Health 2022, 10: s13. DOI: 10.1016/s2214-109x(22)00142-5.Peer-Reviewed Original ResearchStandard cancer careIntegrated palliative carePatient-reported outcomesPalliative careCancer careCost-consequence analysisHealth care costsStudy visitMedical careEarly integrated palliative careHome-based palliative careTotal health care costsPalliative care interventionsOutpatient oncology clinicsPalliative care costsEnd of studyNon-communicable diseasesPocket paymentsMiddle-income countriesOncology clinicOutcome scoresMean ageCare interventionsPatientsEthical approvalAssessing vaccine hesitancy in Arab countries in the Middle East and North Africa (MENA) region: a scoping review protocol
Galal B, Lazieh S, Al-Ali S, Khoshnood K. Assessing vaccine hesitancy in Arab countries in the Middle East and North Africa (MENA) region: a scoping review protocol. BMJ Open 2022, 12: e045348. PMID: 35149559, PMCID: PMC8844954, DOI: 10.1136/bmjopen-2020-045348.Peer-Reviewed Original ResearchConceptsVaccine hesitancyVaccine-preventable disease outbreaksPeer-reviewed open access journalsCOVID-19 vaccinePreferred Reporting ItemsJoanna Briggs Institute ManualMeta-Analyses extensionGreat public health interestPublic health interestScoping Reviews guidelinesVaccine uptakeReporting ItemsEthical approvalSystematic reviewReview protocolStudy titleGoogle ScholarHealth interestSpecific populationsParticipant interventionHesitancyGlobal healthReview guidelinesGrey literatureVaccinationImpulsivity mediates the relationship between childhood maltreatment and quality of life: Does social support make it different?
Gao T, Mei S, Li M, O'Donnell K, Caron J, Meng X. Impulsivity mediates the relationship between childhood maltreatment and quality of life: Does social support make it different? Personality And Individual Differences 2022, 184: 111208. DOI: 10.1016/j.paid.2021.111208.Peer-Reviewed Original ResearchQuality of lifeChildhood maltreatmentLarge community-based cohortSocial supportCommunity-based cohortCross-sectional studyEthical approvalInformed consentStudy sampleAdaptive coping strategiesHistory of maltreatmentCohortHigh impulsivityIntervention effortsEffect of impulsivityAssociationImpulsivityMaltreatmentMediation analysisCoping strategies
2021
Gender disparities among medical students choosing to pursue careers in medical research: a secondary cross-sectional cohort analysis
Snyder A, Xiang D, Smith A, Esswein S, Toubat O, Di Capua J, Kwan JM, Daye D. Gender disparities among medical students choosing to pursue careers in medical research: a secondary cross-sectional cohort analysis. BMC Medical Education 2021, 21: 591. PMID: 34823508, PMCID: PMC8620216, DOI: 10.1186/s12909-021-03004-z.Peer-Reviewed Original ResearchConceptsCross-sectional cohort analysisCohort analysisMore female respondentsAcademic medical centerProportion of womenChi-square testGender disparitiesMedical studentsMedical CenterEthical approvalPatient careMedical researchMore male respondentsMale respondentsFemale respondentsDemographic characteristicsWomenMore male studentsUniversity of PennsylvaniaSelection factorsCramer's VEqual numberMenGender differencesImpact of structured basic life-support course on nurses' cardiopulmonary resuscitation knowledge and skills: Experience of a paediatric department in low-resource country
Umuhoza C, Chen L, Unyuzumutima J, McCall N. Impact of structured basic life-support course on nurses' cardiopulmonary resuscitation knowledge and skills: Experience of a paediatric department in low-resource country. African Journal Of Emergency Medicine 2021, 11: 366-371. PMID: 34367898, PMCID: PMC8327485, DOI: 10.1016/j.afjem.2021.03.014.Peer-Reviewed Original ResearchCentre Hospitalier Universitaire de KigaliOne-rescuer CPRInvestigational Review BoardPediatric departmentCardiopulmonary resuscitation knowledgePublic tertiary care hospitalNurses' baseline knowledgeTertiary level public hospitalTertiary care hospitalPediatric Nurses' KnowledgeBLS trainingBag-mask deviceLow-resource countriesBaseline knowledgeEducational intervention studyBasic life support trainingLife support courseLife support trainingBasic life support courseCare hospitalNurses' knowledgeResuscitation knowledgeEthical approvalAdvanced nursing degreesIntervention studiesConsensus-based approach to managing opioids, including opioid misuse and opioid use disorder, in patients with serious illness: protocol for a modified Delphi process
King C, Arnold R, Dao E, Kapo J, Liebschutz J, Meier D, Paice J, Ritchie C, Czajkowski K, Khodyakov D, Merlin J. Consensus-based approach to managing opioids, including opioid misuse and opioid use disorder, in patients with serious illness: protocol for a modified Delphi process. BMJ Open 2021, 11: e045402. PMID: 34011593, PMCID: PMC8137210, DOI: 10.1136/bmjopen-2020-045402.Peer-Reviewed Original ResearchConceptsOpioid use disorderOpioid misuseSerious illnessInstitutional review boardUse disordersBenefits of opioidsOpioid-related harmsPalliative care cliniciansInstitutional Research BoardPittsburgh Institutional Review BoardOpioid therapyPain managementCare cliniciansPalliative careClinical guidanceEthical approvalIllnessReview boardCliniciansDelphi processPatient casesImplementation toolkitRound 1OpioidsFinal consensusQuality criteria for randomized controlled studies: obstetrical journal guidelines
Anderson K, Romero R, Odibo AO, Rouse D, Marsh M, Acharya G, Chitty L, Ortmann O, Geary M, Gratacos E, Gallagher PG, Gupta J, Renzo GCD, Maulik D, de Costa C, Saade G, Dudenhausen JW, Berghella V. Quality criteria for randomized controlled studies: obstetrical journal guidelines. American Journal Of Obstetrics & Gynecology MFM 2021, 3: 100334. PMID: 33607321, PMCID: PMC8324065, DOI: 10.1016/j.ajogmf.2021.100334.Peer-Reviewed Original ResearchConceptsReporting Trials guidelinesTrials guidelinesConsolidated StandardsEthics committee approvalData sharing statementTRIAL REGISTRATIONProspective registrationCommittee approvalEthical approvalRegistration numberInformed consentPlanned subgroup analysisTop medical journalsMedical journalsPeer-reviewed medical journalsResearch protocolOriginal clinical researchTop general medicineGynecology journalsPeer-reviewed journalsPrimary outcomeSubgroup analysisGeneral medical journalsElectronic submission systemObstetrics
2020
Evidence for Better Lives Study: a comparative birth-cohort study on child exposure to violence and other adversities in eight low- and middle-income countries - foundational research (study protocol)
Valdebenito S, Murray A, Hughes C, Băban A, Fernando A, Madrid B, Ward C, Osafo J, Dunne M, Sikander S, Walker S, Van Thang V, Tomlinson M, Fearon P, Shenderovich Y, Marlow M, Chathurika D, Taut D, Eisner M. Evidence for Better Lives Study: a comparative birth-cohort study on child exposure to violence and other adversities in eight low- and middle-income countries - foundational research (study protocol). BMJ Open 2020, 10: e034986. PMID: 33039982, PMCID: PMC7552842, DOI: 10.1136/bmjopen-2019-034986.Peer-Reviewed Original ResearchConceptsBiological stress markersPregnant womenStress markersDry blood spot samplesPrenatal intimate partner violenceBirth cohort studyPredictors of exposureBlood spot samplesAdverse childhood experiencesHigh-quality longitudinal dataLast trimesterLater healthEpidemiological estimatesEthical approvalHealth servicesEffective interventionsRecruiting sitesPhysical healthChildren's exposureSubstance useParticipant recruitmentPrenatal stageIntimate partner violenceSpot samplesLongitudinal studyTelerehabilitation to Address the Rehabilitation Gap in Anterior Cruciate Ligament Care: Survey of Patients
Dunphy E, Gardner EC. Telerehabilitation to Address the Rehabilitation Gap in Anterior Cruciate Ligament Care: Survey of Patients. JMIR Formative Research 2020, 4: e19296. PMID: 32945776, PMCID: PMC7532455, DOI: 10.2196/19296.Peer-Reviewed Original ResearchStages of carePhysical therapyACL reconstructionAnterior cruciate ligament reconstructionMedicine Institutional Review BoardAcceptability of telerehabilitationCruciate ligament reconstructionUse of telerehabilitationSurvey of patientsPhysical therapy careOpinions of patientsEvidence-based rehabilitationSTATA version 15Time of recruitmentInstitutional review boardQuality of reportingTelerehabilitation interventionTherapy inputACL surgeryLigament reconstructionManual therapyUnmanaged painPatientsRecreational athletesEthical approvalWorksite intervention study to prevent diabetes in Nepal: a randomised trial protocol
Pyakurel P, Shrestha A, Karmacharya BM, Budhathoki SS, Chaudhari RK, Tamrakar D, Shrestha A, Karmacharya RM, Shrestha A, Sharma S, Sharma SK, Spiegelman D. Worksite intervention study to prevent diabetes in Nepal: a randomised trial protocol. Open Heart 2020, 7: e001236. PMID: 32847993, PMCID: PMC7451278, DOI: 10.1136/openhrt-2019-001236.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersBlood GlucoseDiabetes MellitusGlycated HemoglobinHealth BehaviorHealth Knowledge, Attitudes, PracticeHealthy LifestyleHumansMaleMiddle AgedMulticenter Studies as TopicNepalOccupational Health ServicesPatient Education as TopicPrediabetic StatePrimary PreventionRandomized Controlled Trials as TopicRisk Reduction BehaviorTime FactorsTreatment OutcomeConceptsBehavioral interventionsControl periodDiabetes risk reductionMonth control periodNepal Health Research CouncilBehavioral intervention groupWorksite intervention studiesT-testHealth Research CouncilInstitutional review boardTwo-sample t-testBlood sugarTrial protocolIntervention groupEthical approvalControl groupIntervention studiesType 2More monthsReview boardInterventionDiabetesParticipant changesPublic healthRisk reduction
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply