2023
Stress Ulcer Prophylaxis in Mechanically Ventilated Patients With Acute Myocardial Infarction
Banna S, Schenck C, Shahu A, Thomas A, Heck C, Tangredi R, Ali T, Miller P. Stress Ulcer Prophylaxis in Mechanically Ventilated Patients With Acute Myocardial Infarction. JACC Advances 2023, 3: 100750. PMID: 38939822, PMCID: PMC11198220, DOI: 10.1016/j.jacadv.2023.100750.Peer-Reviewed Original ResearchInvasive mechanical ventilationProton pump inhibitorsStress ulcer prophylaxisAcute myocardial infarctionUlcer prophylaxisVentilator-associated pneumoniaMyocardial infarctionVentilator daysST-segment elevation myocardial infarctionBackground Proton pump inhibitorsLess ventilator-associated pneumoniaVizient Clinical Data BaseObservation cohort studyProportion of patientsElevation myocardial infarctionMultivariable logistic regressionClostridium difficile infectionLower hospitalization costsClinical data baseCardiogenic shockHospital mortalityCohort studyMultivariate adjustmentHospitalization costsMechanical ventilation
2018
Stress Gastritis and Stress Ulcers: Prevention and Treatment
Kodadek L, Jones C. Stress Gastritis and Stress Ulcers: Prevention and Treatment. 2018, 231-239. DOI: 10.1007/978-3-319-71712-8_21.ChaptersStress gastritisUlcer prophylaxisMucosal injuryIll patientsStress ulcersEarly enteral nutritionRoutine pharmacologic prophylaxisStress ulcer prophylaxisClostridium difficile colitisGastrointestinal mucosal injuryVentilator-associated pneumoniaLife-threatening hemorrhageTraumatic brain injuryComplex drug interactionsPharmacologic prophylaxisDifficile colitisEnteral nutritionRespiratory failureProphylactic regimensICU patientsMultisystem traumaGuideline recommendationsMultimodal treatmentICU practiceBrain injury
1997
Comparison of Omeprazole and Ranitidine for Stress Ulcer Prophylaxis
Levy M, Seelig C, Robinson N, Ranney J. Comparison of Omeprazole and Ranitidine for Stress Ulcer Prophylaxis. Digestive Diseases And Sciences 1997, 42: 1255-1259. PMID: 9201091, DOI: 10.1023/a:1018810325370.Peer-Reviewed Original ResearchConceptsStress ulcer prophylaxisUlcer prophylaxisRisk factorsComparison of omeprazoleImportant gastrointestinal bleedingAPACHE II scoreHigh-risk patientsSeverity of illnessOmeprazole-treated groupNumber of patientsICU stayVentilator dependenceGastrointestinal bleedingII scoreImportant bleedingOral omeprazoleNasogastric routeStudy groupMortality ratePatientsOmeprazoleBleedingRanitidineProphylaxisSignificant differences
1991
Nosocomial Pneumonia and the Role of Gastric pH A Meta-Analysis
Cook D, Laine L, Guyatt G, Raffin T. Nosocomial Pneumonia and the Role of Gastric pH A Meta-Analysis. CHEST Journal 1991, 100: 7-13. PMID: 1676361, DOI: 10.1378/chest.100.1.7.Peer-Reviewed Original ResearchConceptsStress ulcer prophylaxisUse of sucralfateIncidence of pneumoniaUlcer prophylaxisNosocomial pneumoniaIll patientsGastric pHHistamine-2 receptor antagonistsLarger prospective randomized trialsPercent risk reductionTrial of prophylaxisProspective randomized trialsComputerized bibliographic searchDuplicate independent reviewEffect of antacidIndependent reviewProphylactic therapyRandomized trialsDecreased incidenceControl therapyOdds ratioCommon odds ratioLower incidenceMethodologic deficienciesPneumonia
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