2021
The influence of biological age and sex on long-term outcome after percutaneous coronary intervention for ST-elevation myocardial infarction.
Rathod KS, Jones DA, Jain AK, Lim P, MacCarthy PA, Rakhit R, Lockie T, Kalra S, Dalby MC, Malik IS, Whitbread M, Firoozi S, Bogle R, Redwood S, Cooper J, Gupta A, Lansky A, Wragg A, Mathur A, Ahluwalia A. The influence of biological age and sex on long-term outcome after percutaneous coronary intervention for ST-elevation myocardial infarction. Am J Cardiovasc Dis 2021, 11: 659-678. PMID: 34849299, PMCID: PMC8611266.Peer-Reviewed Original ResearchST-segment elevation myocardial infarctionCause mortalityFemale sexCox analysisMyocardial infarctionST-elevation myocardial infarctionAge-matched menObservational cohort studyElevation myocardial infarctionPercutaneous coronary interventionKaplan-Meier analysisLong-term outcomesProportional hazards modelSub-group analysisHigh mortality rateYears of agePost-PCIPrimary PCICoronary interventionSTEMI patientsCohort studyMultivariate adjustmentPrimary outcomeUnivariate predictorsMenopausal years
2019
Anti‐inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid‐induced insulin resistance
Camporez JP, Lyu K, Goldberg EL, Zhang D, Cline GW, Jurczak MJ, Dixit VD, Petersen KF, Shulman GI. Anti‐inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid‐induced insulin resistance. The Journal Of Physiology 2019, 597: 3885-3903. PMID: 31206703, PMCID: PMC6876753, DOI: 10.1113/jp277270.Peer-Reviewed Original ResearchConceptsObesity-induced insulin resistanceHigh-fat dietEctopic lipid contentWhite adipose tissue lipolysisInsulin resistanceAdipose tissue lipolysisMale miceInsulin sensitivityFemale miceInsulin-stimulated suppressionWAT inflammationTissue lipolysisRodent studiesTumor necrosis factor αWhole-body insulin sensitivityLipid-induced insulin resistanceMetabolic homeostasisAge-matched menInterleukin-6 concentrationsSkeletal muscleAnti-inflammatory effectsType 2 diabetesInsulin-mediated suppressionSexual dimorphic responseNecrosis factor α
2015
Mortality Rates Associated With Odontoid and Subaxial Cervical Spine Fractures.
Miller CP, Golinvaux NS, Brubacher JW, Bohl DD, Deng Y, Grauer JN. Mortality Rates Associated With Odontoid and Subaxial Cervical Spine Fractures. The American Journal Of Orthopedics 2015, 44: e173-9. PMID: 26047001.Peer-Reviewed Original ResearchConceptsCervical spine fracturesSpine fracturesSex-matched counterpartsMortality rateSubaxial fracturesGeneral populationSubaxial cervical spine fracturesAge-matched dataAge-matched menNational Death IndexMortality of menRetrospective reviewDeath IndexEmergency departmentCervical spineLevel IDeath recordsElderly personsOlder individualsSurvivalMonthsDevastating consequencesFracturesAgeMen
2014
Gender‐specific Research for Emergency Diagnosis and Management of Ischemic Heart Disease: Proceedings from the 2014 Academic Emergency Medicine Consensus Conference Cardiovascular Research Workgroup
Safdar B, Nagurney JT, Anise A, DeVon HA, D'Onofrio G, Hess EP, Hollander JE, Legato MJ, McGregor AJ, Scott J, Tewelde S, Diercks DB. Gender‐specific Research for Emergency Diagnosis and Management of Ischemic Heart Disease: Proceedings from the 2014 Academic Emergency Medicine Consensus Conference Cardiovascular Research Workgroup. Academic Emergency Medicine 2014, 21: 1350-1360. PMID: 25413468, PMCID: PMC6402042, DOI: 10.1111/acem.12527.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseIschemic heart diseaseHeart diseaseCardiac ischemiaSymptomatic coronary artery diseaseObstructive coronary artery diseaseSex-specific pathophysiologyCoronary artery dissectionAge-matched menSex-specific riskPatient-centered outcomesPatient-provider communicationHealth care practitionersEmergency medical servicesGender-specific researchAcademic Emergency Medicine consensus conferencePerson meetingsBasic science researchArtery dissectionCardiovascular outcomesMonthly conference callsMicrovascular dysfunctionArtery diseasePatient outcomesCardiac biomarkersMenopause and metabolic syndrome in obese individuals with binge eating disorder
Udo T, McKee SA, White MA, Masheb RM, Barnes RD, Grilo CM. Menopause and metabolic syndrome in obese individuals with binge eating disorder. Eating Behaviors 2014, 15: 182-185. PMID: 24854801, PMCID: PMC4032475, DOI: 10.1016/j.eatbeh.2014.01.003.Peer-Reviewed Original ResearchConceptsAge-matched menPostmenopausal womenPremenopausal womenMetabolic syndromeMetabolic abnormalitiesPoor glycemic controlElevated total cholesterolLow HDL levelsChronic medical conditionsHigh-risk populationSymptoms of BEDMetabolic functionsObese menObese womenBlood pressureGlycemic controlTotal cholesterolHDL levelsObese individualsMenopausal transitionGlucose levelsMedical conditionsEarly interventionTreatment studiesElevated levels
2002
What is “biochemical failure” in prostate cancer?
Lagu T, Wells C, Penson D, Concato J. What is “biochemical failure” in prostate cancer? Journal Of Clinical Epidemiology 2002, 55: 631. DOI: 10.1016/s0895-4356(02)00425-0.Peer-Reviewed Original ResearchProstate-specific antigenPSA failureMedian timeType of treatmentPSA slopeProstate cancerPost-treatment prostate-specific antigenVeterans Affairs Healthcare SystemAge-matched menProportion of menBiochemical failureSurgical failureTreatment failureSurrogate endpointsTherapeutic radiationAbility of providersVA sitesActual therapyPatientsClinical phenomenaCancerKappa statisticsHealthcare systemMenAmerican Society
2000
Comparison of the percent free prostate-specific antigen levels in the serum of healthy men and in men with recurrent prostate cancer after radical prostatectomy
Scorilas A, Yu H, Soosaipillai A, Gregorakis A, Diamandis E. Comparison of the percent free prostate-specific antigen levels in the serum of healthy men and in men with recurrent prostate cancer after radical prostatectomy. Clinica Chimica Acta 2000, 292: 127-138. PMID: 10686282, DOI: 10.1016/s0009-8981(99)00211-9.Peer-Reviewed Original ResearchConceptsPercent free PSAProstate cancer patientsFree PSAProstate cancerCancer patientsRadical prostatectomyPercent free prostate-specific antigen levelsCancer aggressivenessFree prostate specific antigen levelsProstate-specific antigen levelProstate cancer screening programsAge-matched menCancer screening programsRecurrent prostate cancerBenign prostatic hyperplasiaProstate cancer aggressivenessAntigen levelsTotal PSAGleason scoreHealthy menProstatic hyperplasiaProstatic diseaseScreening programPatientsPathological indicators
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