2020
Analysis of Opioid-Seeking Behavior Through the Intravenous Self-Administration Reinstatement Model in Rats
Fattore L, Fadda P, Zanda M, Fratta W. Analysis of Opioid-Seeking Behavior Through the Intravenous Self-Administration Reinstatement Model in Rats. Methods In Molecular Biology 2020, 2201: 231-245. PMID: 32975804, DOI: 10.1007/978-1-0716-0884-5_21.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAnalgesics, OpioidAnimalsBehavior ControlBehavior, AddictiveConditioning, OperantCuesDisease Models, AnimalDrug-Seeking BehaviorHeroinInfusions, IntravenousMaleOpioid-Related DisordersRatsRats, Sprague-DawleyRats, WistarReinforcement, PsychologyRewardSelf AdministrationSubstance-Related DisordersConceptsNeurobiological mechanismsAnimal model of relapseExtinction-reinstatement modelHeroin-seeking behaviorReinstatement animal modelRelapse-like behaviorModel of relapseRelapse to heroinVulnerability to relapseNose poke responsesPanel press responseNonhuman primatesReinstatement modelDrug seekingLever pressOperant respondingDrug abstinenceAddiction researchVulnerability factorsPress responseSubstance useOperant responseAnimal modelsIndividual slipsSelf-Administered
2019
Cholinergic Receptor Blockade in the VTA Attenuates Cue-Induced Cocaine-Seeking and Reverses the Anxiogenic Effects of Forced Abstinence
Nunes EJ, Bitner L, Hughley SM, Small KM, Walton SN, Rupprecht LE, Addy NA. Cholinergic Receptor Blockade in the VTA Attenuates Cue-Induced Cocaine-Seeking and Reverses the Anxiogenic Effects of Forced Abstinence. Neuroscience 2019, 413: 252-263. PMID: 31271832, PMCID: PMC6661179, DOI: 10.1016/j.neuroscience.2019.06.028.Peer-Reviewed Original ResearchConceptsCue-induced cocaineAnxiety-related behaviorDrug relapseOpen arm timeCholinergic receptor blockadeCocaine abstinenceVentral tegmental areaSubstance abuseSelf-administer intravenous cocaineMuscarinic receptor antagonist scopolaminePeriod of abstinenceAnxiogenic effectsReceptor blockadeCholinergic mechanismsCocaine-naïve ratsNicotinic acetylcholine receptor antagonist mecamylamineMale Sprague-Dawley ratsDrug abstinenceSprague-Dawley ratsDose-dependent increaseCocaine-naive ratsAntagonist scopolamineEPM behaviorSaline ratsAbstinence
2018
A randomized clinical trial of the Recovery Line among methadone treatment patients with ongoing illicit drug use
Moore BA, Buono FD, Lloyd DP, Printz DMB, Fiellin DA, Barry DT. A randomized clinical trial of the Recovery Line among methadone treatment patients with ongoing illicit drug use. Journal Of Substance Use And Addiction Treatment 2018, 97: 68-74. PMID: 30577901, PMCID: PMC6310054, DOI: 10.1016/j.jsat.2018.11.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitive Behavioral TherapyCombined Modality TherapyFemaleHumansIllicit DrugsMaleMethadoneMiddle AgedNarcoticsOpiate Substitution TreatmentOutcome and Process Assessment, Health CareSelf ReportSelf-Help GroupsSelf-ManagementSubstance Abuse DetectionSubstance-Related DisordersTelephoneConceptsMethadone treatment patientsIllicit drug useDrug useTreatment patientsUrine screensOngoing illicit drug useDrug abstinencePrevious small trialsClinical efficacy trialsSelf-reported abstinenceRandomized clinical trialsIllicit drugsSubstance use disordersSelf-management systemCognitive behavioral therapyAdjunctive treatmentPrimary outcomeMethadone treatmentSmall trialsClinical trialsEfficacy trialsAbstinence outcomesUse disordersPatient engagementPatients
2016
Nicotine and Nicotine Abstinence Do Not Interfere with GABAA Receptor Neuroadaptations During Alcohol Abstinence
Hillmer AT, Kloczynski T, Sandiego CM, Pittman B, Anderson JM, Labaree D, Gao H, Huang Y, Deluliis G, O'Malley SS, Carson RE, Cosgrove KP. Nicotine and Nicotine Abstinence Do Not Interfere with GABAA Receptor Neuroadaptations During Alcohol Abstinence. Alcohol Clinical And Experimental Research 2016, 40: 698-705. PMID: 26971694, PMCID: PMC4983773, DOI: 10.1111/acer.12997.Peer-Reviewed Original ResearchConceptsGABAA receptor availabilityPositron emission tomographyAlcohol abstinenceAlcohol withdrawalNicotine abstinenceReceptor availabilityTobacco smokingNonhuman primatesContinued nicotine useNicotine replacement therapyWeeks of abstinenceSelf-administer alcoholAdolescent male rhesus macaquesDays of abstinenceSignificant group effectMale rhesus macaquesNicotine cessationNicotine exposureReplacement therapyNicotine useAlcohol dependenceEmission tomographyDrug abstinenceSmokingNicotine
2014
Analysis of Opioid-Seeking Reinstatement in the Rat
Fattore L, Fadda P, Zanda M, Fratta W. Analysis of Opioid-Seeking Reinstatement in the Rat. Methods In Molecular Biology 2014, 1230: 295-307. PMID: 25293336, DOI: 10.1007/978-1-4939-1708-2_25.Peer-Reviewed Original ResearchConceptsNeurobiological mechanismsAnimal model of relapseReinstatement animal modelRelapse-like behaviorHeroin-seeking behaviorRelapse to heroinVulnerability to relapseModel of relapseNose poke responsesPanel press responseNonhuman primatesReinstatement modelDrug seekingLever pressOperant respondingDrug abstinenceAddiction researchPress responseVulnerability factorsConditioned behaviorReinstatementSubstance useOperant responseAnimal modelsIndividual slips
2012
GABRA2 Genotype, Impulsivity, and Body Mass
Bauer LO, Yang B, Houston RJ, Kranzler HR, Gelernter J. GABRA2 Genotype, Impulsivity, and Body Mass. American Journal On Addictions 2012, 21: 404-410. PMID: 22882390, PMCID: PMC3773931, DOI: 10.1111/j.1521-0391.2012.00252.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttention Deficit Disorder with HyperactivityBody Mass IndexCase-Control StudiesConnecticutFemaleGenotypeHumansImpulsive BehaviorMaleMiddle AgedPolymorphism, Single NucleotidePsychiatric Status Rating ScalesReceptors, GABA-ASex FactorsSubstance Abuse Treatment CentersSubstance-Related DisordersConceptsBody mass indexElevated body mass indexAssociation of BMIGABRA2 genotypeSubstance dependenceAttention-deficit/hyperactivity disorderHigh-calorie foodsPrevious pregnancyMass indexElectroencephalographic featuresRisk factorsChildhood symptomsScale scoreDrug abstinenceCalorie foodsHyperactivity disorderGenetic findingsWomenLonger durationBarratt Impulsiveness ScalePsychological indicatorsGABRA2 variantsSex differencesSecond analysisBody mass
2008
Cocaine Users Differ from Normals on Cognitive Tasks Which Show Poorer Performance During Drug Abstinence
Pace-Schott EF, Morgan PT, Malison RT, Hart CL, Edgar C, Walker M, Stickgold R. Cocaine Users Differ from Normals on Cognitive Tasks Which Show Poorer Performance During Drug Abstinence. The American Journal Of Drug And Alcohol Abuse 2008, 34: 109-121. PMID: 18161649, DOI: 10.1080/00952990701764821.Peer-Reviewed Original ResearchConceptsVerbal recognition memoryCocaine usersCocaine-dependent individualsCocaine-induced impairmentRecognition memoryCognitive tasksCognitive batteryCognitive changesDrug-free baselineDrug abstinenceAbstinencePoor performanceMemoryCocaine useDrug useDay cocaineNormative valuesAttentionCocaineTaskImpairmentIndividualsBatteriesInpatient study
2007
Reflections by Inner-City Drug Users on a Buddhist-Based Spirituality-Focused Therapy: A Qualitative Study
Beitel M, Genova M, Schuman-Olivier Z, Arnold R, Avants SK, Margolin A. Reflections by Inner-City Drug Users on a Buddhist-Based Spirituality-Focused Therapy: A Qualitative Study. American Journal Of Orthopsychiatry 2007, 77: 1-9. PMID: 17352579, DOI: 10.1037/0002-9432.77.1.1.Peer-Reviewed Original ResearchConceptsSpirituality-focused interventionsSpiritual Self-Schema TherapyHIV risk behaviorsInner-city drug usersTreatment of addictionClinical trialsHIV preventionQualitative studyDrug usersDrug abstinenceTherapyTherapy development processAddiction treatmentInterventionSemistructured interviewsFocus groupsTreatmentAddicted clientsPersonal experienceClient's personal experienceAbstinence
2005
The role of depression symptoms in predicting drug abstinence in outpatient substance abuse treatment
Dodge R, Sindelar J, Sinha R. The role of depression symptoms in predicting drug abstinence in outpatient substance abuse treatment. Journal Of Substance Use And Addiction Treatment 2005, 28: 189-196. PMID: 15780549, DOI: 10.1016/j.jsat.2004.12.005.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmbulatory CareComorbidityConnecticutCross-Sectional StudiesDepressionFemaleFinancing, GovernmentHumansMaleMiddle AgedMotivationPatient CompliancePatient DischargePublic AssistanceRegression AnalysisSecondary PreventionSocioeconomic FactorsSubstance Abuse DetectionSubstance-Related DisordersTreatment OutcomeConceptsLength of staySubstance abuse treatment outcomesOutpatient substance abuse treatmentSubstance abuse treatmentDepressive symptomsInsurance statusTreatment outcomesAbstinence statusDepression symptomsDrug useDrug abstinenceAbuse treatmentReal-world clinical settingHigher depressive symptom scoresOutpatient substance abuse treatment programsDepressive symptom scoresSubstance abuse treatment programsSymptom scoresTreatment characteristicsPrimary drugDecreased likelihoodReferral sourceClinical settingSymptomsTreatment program
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