2023
Impact of Digital Health Technology on Quality of Life in Patients With Heart Failure
Victoria-Castro A, Martin M, Yamamoto Y, Melchinger H, Weinstein J, Nguyen A, Lee K, Gerber B, Calderon F, Subair L, Lee V, Williams A, Shaw M, Arora T, Garcez A, Desai N, Ahmad T, Wilson F. Impact of Digital Health Technology on Quality of Life in Patients With Heart Failure. JACC Heart Failure 2023, 12: 336-348. PMID: 37943227, DOI: 10.1016/j.jchf.2023.09.022.Peer-Reviewed Original ResearchOverall summary scoreClinical summary scoreTotal symptom scoreKCCQ overall summary scoreUsual careHeart failureQuality of lifeMedian changeKansas City Cardiomyopathy Questionnaire overall summary scoreSummary scoresMedian agePrimary outcomeSymptom scoresPhysical functionLongitudinal carePatientsDigital health toolsLarger studyDigital health technologiesHealth toolsQoLCareDigital interventionsIndependent effectsHealth technologiesExercise Does Not Independently Improve Histological Outcomes in Biopsy-Proven Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Chen G, Banini B, Do A, Gunderson C, Zaman S, Lim J. Exercise Does Not Independently Improve Histological Outcomes in Biopsy-Proven Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis. Genes 2023, 14: 1811. PMID: 37761951, PMCID: PMC10531443, DOI: 10.3390/genes14091811.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseBiopsy-proven non-alcoholic fatty liver diseaseEffects of exerciseFatty liver diseaseHistological outcomesLiver histologyLiver diseaseClinical trialsHistological endpointsSystematic reviewSignificant histopathological improvementNAFLD activity scoreImpact of exerciseIndependent effectsRandom-effects modelSystematic literature searchHistopathological improvementExercise interventionActivity scoreClinical endpointsPooled estimatesMeta-analysisTotal participantsLiterature searchComparison group
2022
The Independent Effect of Exercise on Biopsy-Proven Non-Alcoholic Fatty Liver Disease: A Systematic Review
Chen G, Banini B, Do A, Lim J. The Independent Effect of Exercise on Biopsy-Proven Non-Alcoholic Fatty Liver Disease: A Systematic Review. Clinical And Molecular Hepatology 2022, 29: s319-s332. PMID: 36517000, PMCID: PMC10029942, DOI: 10.3350/cmh.2022.0366.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseBiopsy-proven non-alcoholic fatty liver diseaseNon-invasive testsFatty liver diseaseHepatic steatosisLiver fibrosisLiver diseaseHistological endpointsIndependent effectsSystematic reviewNon-randomized interventional studyMagnetic resonance imaging-based techniquesAdditional large RCTsChronic liver diseaseSignificant histological improvementEffects of exerciseClinical outcome endpointsSystematic literature searchHistological improvementExercise interventionHepatocyte ballooningOriginal research studiesLarge RCTsOutcome endpointsInterventional study
2021
Interpersonal Associations Between Affect and Depressive Symptoms in Persons With Early Dementia and Their Spouses
Piechota A, Syed S, Monin J. Interpersonal Associations Between Affect and Depressive Symptoms in Persons With Early Dementia and Their Spouses. Innovation In Aging 2021, 5: 298-298. PMCID: PMC8969213, DOI: 10.1093/geroni/igab046.1152.Peer-Reviewed Original ResearchNegative affectInterpersonal associationsSelf-reported affective experienceDepressive symptomsOwn negative affectOwn positive affectStress reduction interventionsPartner's depressive symptomsOwn depressive symptomsGreater depressive symptomsPositive affectPartner effectsAffective experiencePsychological healthLower depressive symptomsAffectEarly dementiaRandomized clinical trialsReduction interventionsSpousesClinical trialsBaseline interviewSecondary analysisSymptomsIndependent effectsPrevalence of Advanced Colorectal Neoplasia in Veterans
Imperiale TF, Daggy JK, Imler TD, Sherer EA, Kahi CJ, Larson J, Cardwell J, Johnson CS, Ahnen DJ, Antaki F, Ashley C, Baffy G, Dominitz JA, Hou J, Korsten MA, Nagar A, Promrat K, Robertson DJ, Saini S, Shergill A, Smalley WE. Prevalence of Advanced Colorectal Neoplasia in Veterans. Journal Of Clinical Gastroenterology 2021, 55: 876-883. PMID: 34049372, DOI: 10.1097/mcg.0000000000001402.Peer-Reviewed Original ResearchConceptsAdvanced neoplasiaProximal colorectal cancerColorectal cancerVeterans Affairs Medical CenterProximal advanced neoplasiaAdvanced colorectal neoplasiaCross-sectional studyIndependent effectsHigh overall prevalenceRace/ethnicityCRC prevalenceColorectal neoplasiaCRC riskOverall prevalenceMedical CenterDiagnostic subgroupsLogistic regressionPrevalenceAgeVeteransWomenColonoscopyNeoplasiaRiskAdvanced findingsThe independent and combined influences of small for gestational age and socioeconomic status on newborn metabolite levels
McCarthy M, Oltman S, Rogers E, Ryckman K, Jelliffe-Pawlowski L, Danilack V. The independent and combined influences of small for gestational age and socioeconomic status on newborn metabolite levels. The Journal Of Maternal-Fetal & Neonatal Medicine 2021, 35: 6192-6198. PMID: 33882790, DOI: 10.1080/14767058.2021.1909562.Peer-Reviewed Original ResearchConceptsSocioeconomic statusGestational ageMetabolite levelsHospital discharge dataDose-response relationshipEffect of SESNewborn interventionsSGA infantsSGA statusRetrospective cohortSmall birthweightFree carnitineBetter outcomesSGAMajority of metabolitesNutritional Assistance ProgramCalifornia infantsInfant's levelInfantsSelect metabolitesMedical insuranceAge exhibitIndependent effectsBirthweightEducation level
2020
Frailty Is Independently Associated with Mortality and Readmission in Hospitalized Patients with Inflammatory Bowel Diseases
Qian A, Nguyen N, Elia J, Ohno-Machado L, Sandborn W, Singh S. Frailty Is Independently Associated with Mortality and Readmission in Hospitalized Patients with Inflammatory Bowel Diseases. Clinical Gastroenterology And Hepatology 2020, 19: 2054-2063.e14. PMID: 32801013, PMCID: PMC7930013, DOI: 10.1016/j.cgh.2020.08.010.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseCause of hospitalizationHigh riskFrail patientsBowel diseaseSevere inflammatory bowel diseaseNationwide Readmissions DatabaseRisk of readmissionBurden of hospitalizationRisk of complicationsCost of hospitalizationBenefits of treatmentIndependent effectsRepresentative cohort studyIndex admissionMedian followCause readmissionComorbidity indexIndex hospitalizationCohort studyInpatient mortalityOlder patientsFrailty riskHospitalized patientsLongitudinal burdenHuman Papillomavirus 16/18–Associated Cervical Lesions: Differences by Area-Based Measures of Race and Poverty
Brackney MM, Gargano JW, Hannagan SE, Meek J, Querec TD, Niccolai LM. Human Papillomavirus 16/18–Associated Cervical Lesions: Differences by Area-Based Measures of Race and Poverty. American Journal Of Preventive Medicine 2020, 58: e149-e157. PMID: 32001053, DOI: 10.1016/j.amepre.2019.12.003.Peer-Reviewed Original ResearchConceptsHuman papillomavirus 16/18Area-based measuresProportion of lesionsCervical lesionsMultivariable logistic regression modelingHuman papillomavirus vaccineLogistic regression modelingPapillomavirus vaccineHuman papillomavirusInsurance statusNew Haven CountyHealth outcomesCensus tract characteristicsSociodemographic characteristicsLesionsIndependent effectsRegression modelingWomenEarly declineSignificant declineEthnicityHourly Exposure to Ultrafine Particle Metrics and the Onset of Myocardial Infarction in Augsburg, Germany
Chen K, Schneider A, Cyrys J, Wolf K, Meisinger C, Heier M, von Scheidt W, Kuch B, Pitz M, Peters A, Breitner S, Group F. Hourly Exposure to Ultrafine Particle Metrics and the Onset of Myocardial Infarction in Augsburg, Germany. Environmental Health Perspectives 2020, 128: 017003. PMID: 31939685, PMCID: PMC7015564, DOI: 10.1289/ehp5478.Peer-Reviewed Original ResearchConceptsMyocardial infarctionMI casesTime-stratified case-crossover analysisConditional logistic regressionInterquartile range increaseCase-crossover analysisTwo-pollutant modelsMI registryEpidemiological evidenceDifferent particle metricsCardiovascular diseaseMyocardial infractionSimilar associationLogistic regressionHourly air pollutionParticle metricsEffect estimatesHealth effectsExposure metricsIndependent effectsTransient exposureInfarctionAssociationExposureAerodynamic diameter
2019
Childhood Trauma and Stressful Life Events Are Independently Associated with Sleep Disturbances in Adolescents
Baddam SKR, Olvera RL, Canapari CA, Crowley MJ, Williamson DE. Childhood Trauma and Stressful Life Events Are Independently Associated with Sleep Disturbances in Adolescents. Behavioral Sciences 2019, 9: 108. PMID: 31658779, PMCID: PMC6826433, DOI: 10.3390/bs9100108.Peer-Reviewed Original ResearchStressful life eventsLife eventsChildhood traumaSleep patternsSleep disturbancesRecent stressful life eventsAdolescent sleep patternsSelf-report questionnairesAppearance of anxietyCritical developmental periodSleep regularitySleep pressureSleep factorsAnxietyDevelopmental periodIndependent effectsDepressive symptomsAdolescentsDepressionDepressive disorderSleep questionsTraumaAdolescenceSleepDisordersIndependent Effect of High Aerobic Capacity To Protect Against Diet-Induced Insulin Resistance in Male Rats
Stachenfeld NS. Independent Effect of High Aerobic Capacity To Protect Against Diet-Induced Insulin Resistance in Male Rats. Endocrinology 2019, 160: 1437-1438. PMID: 31046086, DOI: 10.1210/en.2019-00292.Commentaries, Editorials and LettersPrevalence and multi-morbid correlates of homelessness among veterans with HIV infection nationally in the veterans health administration
Stefanovics EA, Rosenheck RA. Prevalence and multi-morbid correlates of homelessness among veterans with HIV infection nationally in the veterans health administration. Psychology Health & Medicine 2019, 24: 1123-1136. PMID: 30900465, DOI: 10.1080/13548506.2019.1595680.Peer-Reviewed Original ResearchConceptsRisk factorsNational VHA administrative dataVeterans Health Administration (VHA) servicesVHA administrative dataVeterans Health AdministrationHIV-positive veteransPreventive psychosocial interventionsHIV-positive usersHIV diagnosisHIV infectionUnadjusted riskFiscal year 2012Independent riskHigh riskHIVPsychosocial interventionsHealth AdministrationSubstantial riskIndependent effectsVeteransRiskAdministrative dataRisk of homelessnessCorrelatesInfection
2017
After Posterior Fusions for Adult Spinal Deformity, Operative Time is More Predictive of Perioperative Morbidity, Rather Than Surgical Invasiveness
Samuel AM, Fu MC, Anandasivam NS, Webb ML, Lukasiewicz AM, Kim HJ, Grauer JN. After Posterior Fusions for Adult Spinal Deformity, Operative Time is More Predictive of Perioperative Morbidity, Rather Than Surgical Invasiveness. Spine 2017, 42: 1880-1887. PMID: 28538595, DOI: 10.1097/brs.0000000000002243.Peer-Reviewed Original ResearchConceptsAdult spinal deformityPosterior spinal fusionOperative timeSurgical invasivenessSpinal deformitySpinal fusionMultivariate analysisPerioperative outcomesPosterior fusionOperative timingNational Surgical Quality Improvement Program databaseIndependent effectsQuality Improvement Program databaseImprovement Program databaseRetrospective cohort studyLonger operative timeOverall operative timeAdult deformity surgeryInvasive surgical proceduresInpatient complicationsPerioperative complicationsPerioperative morbidityAdult patientsCohort studyDeformity surgeryQuality of Life in Chronic Pancreatitis is Determined by Constant Pain, Disability/Unemployment, Current Smoking, and Associated Co-Morbidities
Machicado JD, Amann ST, Anderson MA, Abberbock J, Sherman S, Conwell DL, Cote GA, Singh VK, Lewis MD, Alkaade S, Sandhu BS, Guda NM, Muniraj T, Tang G, Baillie J, Brand RE, Gardner TB, Gelrud A, Forsmark CE, Banks PA, Slivka A, Wilcox CM, Whitcomb DC, Yadav D. Quality of Life in Chronic Pancreatitis is Determined by Constant Pain, Disability/Unemployment, Current Smoking, and Associated Co-Morbidities. The American Journal Of Gastroenterology 2017, 112: 633. PMID: 28244497, PMCID: PMC5828017, DOI: 10.1038/ajg.2017.42.Peer-Reviewed Original ResearchConceptsQuality of lifeMild-moderate painCurrent smokingChronic pancreatitisMCS scoresConstant painCP patientsSevere painShort Form-12 (SF-12) surveyMental component summary scoresConstant severe painComponent summary scoresMultivariable linear regression modelsAssociated co morbiditiesIndependent effectsFinal multivariable modelNAPS2 studySignificant independent effectDisease durationCo morbiditiesMean PCSIndependent predictorsMultivariable analysisPancreatic surgeryPCS scores
2013
Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects
Patsopoulos NA, Barcellos LF, Hintzen RQ, Schaefer C, van Duijn CM, Noble JA, Raj T, Gourraud P, Stranger B, Oksenberg PA, Olsson BE, Taylor J, Sawcer T, Hafler BV, Carrington S, De Jager DA, de Bakker M. Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects. PLOS Genetics 2013, 9: e1003926. PMID: 24278027, PMCID: PMC3836799, DOI: 10.1371/journal.pgen.1003926.Peer-Reviewed Original ResearchMeSH KeywordsAllelesChromosome MappingGenetic Predisposition to DiseaseGenome-Wide Association StudyHaplotypesHistocompatibility Antigens Class IHLA-DP beta-ChainsHLA-DRB1 ChainsHumansIntracellular Signaling Peptides and ProteinsLinkage DisequilibriumMajor Histocompatibility ComplexMembrane ProteinsMultiple SclerosisPolymorphism, Single NucleotideReceptors, Tumor Necrosis Factor, Type IConceptsHuman leukocyte antigenNon-HLA risk allelesRisk allelesClassical human leukocyte antigenClass IMultiple sclerosis susceptibilityHLA class IIndependent effectsMS susceptibility geneMajor histocompatibility complexMajor histocompatibility complex regionHLA effectMultiple sclerosisLeukocyte antigenHLA-DRB1MS susceptibilityMultiple risk allelesDPB1 allelesClass IIPeptide-binding grooveHistocompatibility complexPolymorphic amino acid positionsTNF geneClassical allelesSusceptibility genes
2012
Counseling and Directly Observed Medication for Primary Care Buprenorphine Maintenance
Moore BA, Barry DT, Sullivan LE, O'Connor PG, Cutter CJ, Schottenfeld RS, Fiellin DA. Counseling and Directly Observed Medication for Primary Care Buprenorphine Maintenance. Journal Of Addiction Medicine 2012, 6: 205-211. PMID: 22614936, PMCID: PMC3419276, DOI: 10.1097/adm.0b013e3182596492.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyPhysician managementObserved medicationBaseline characteristicsCBT sessionsOpioid-negative urinesIndividual CBT sessionsBuprenorphine maintenanceOpioid useMedication adherencePatient satisfactionPrimary careImproved outcomesTreatment outcomesSession attendanceNegative urineTreatment groupsGreater abstinenceCounseling intensityDrug useTherapist availabilityMedicationsBuprenorphinePatientsIndependent effects
2010
Complementary approaches to assessing risk factors for interval breast cancer
Lowery J, Byers T, Hokanson J, Kittelson J, Lewin J, Risendal B, Singh M, Mouchawar J. Complementary approaches to assessing risk factors for interval breast cancer. Cancer Causes & Control 2010, 22: 23-31. PMID: 20978835, DOI: 10.1007/s10552-010-9663-x.Peer-Reviewed Original ResearchConceptsInterval breast cancersInterval cancersDense breastsRisk of interval cancerFamily historyBreast cancerScreen-detected cancersRisk factorsMammography programsScreened womenBreast densityHormone useIntensive screeningLogistic regressionNegative screeningYounger ageIndependent effectsWomenBreastDisproportionate numberReduced occurrenceCancerRiskScreeningIncidenceBeyond insurance coverage: Usual source of care in the treatment of hypertension and hypercholesterolemia. Data from the 2003-2006 National Health and Nutrition Examination Survey
Spatz ES, Ross JS, Desai MM, Canavan ME, Krumholz HM. Beyond insurance coverage: Usual source of care in the treatment of hypertension and hypercholesterolemia. Data from the 2003-2006 National Health and Nutrition Examination Survey. American Heart Journal 2010, 160: 115-121. PMID: 20598981, PMCID: PMC3025407, DOI: 10.1016/j.ahj.2010.04.013.Peer-Reviewed Original ResearchConceptsTreatment of hypertensionNutrition Examination SurveyInsurance statusMedication treatmentExamination SurveyNational HealthUsual sourceAdult Treatment Panel III recommendationsJoint National Committee 7Multivariable logistic regression modelingInsurance coverageSeparate multivariable modelsChronic disease managementLogistic regression modelingHigh-quality careRace/ethnicityCardiovascular diseaseMultivariable modelStratified analysisHypertensionHypercholesterolemiaRegular sourceCareDisease managementIndependent effectsWhether medically unexplained or not, three or more concurrent somatic symptoms predict psychopathology and service use in community populations
Escobar JI, Cook B, Chen CN, Gara MA, Alegría M, Interian A, Diaz E. Whether medically unexplained or not, three or more concurrent somatic symptoms predict psychopathology and service use in community populations. Journal Of Psychosomatic Research 2010, 69: 1-8. PMID: 20630257, PMCID: PMC2905311, DOI: 10.1016/j.jpsychores.2010.01.001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnxiety DisordersAsianCommunity Health ServicesComorbidityCross-Cultural ComparisonDepressive DisorderFemaleHispanic or LatinoHumansMaleMental DisordersMiddle AgedSomatoform DisordersStatistics as TopicSubstance-Related DisordersUtilization ReviewWhite PeopleYoung AdultConceptsGeneral physical symptomsPhysical symptomsService useSomatic symptomsCommunity populationUse of servicesPsychological distressCommon mental disordersUnexplained physical symptomsSubstance use disordersSignificant independent effectUnadjusted comparisonsPsychiatric disordersUse disordersMental disordersSymptomsMUPSSignificant predictorsIndependent effectsMedical explanationDisordersMultivariate regressionRegression analysisOne-thirdDistress
2009
Racial and ethnic differences in reproductive potential across the life cycle
Butts SF, Seifer DB. Racial and ethnic differences in reproductive potential across the life cycle. Fertility And Sterility 2009, 93: 681-690. PMID: 19939362, DOI: 10.1016/j.fertnstert.2009.10.047.Peer-Reviewed Original ResearchConceptsRacial disparitiesLive birth rateReproductive health outcomesEthnic groupsRace/ethnicityMenopausal symptomsClinical endpointsMenopausal transitionMEDLINE searchHispanic womenPotential confoundingHealth outcomesReproductive healthReproductive life cycleNumber of reportsPubertal onsetEarly pubertySmall sample sizeEthnic differencesIndependent effectsReproductive technologiesOutcomesBirth rateContinuum of eventsReproductive life span
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