2011
Two types of chloride transporters are required for GABAA receptor‐mediated inhibition in C. elegans
Bellemer A, Hirata T, Romero MF, Koelle MR. Two types of chloride transporters are required for GABAA receptor‐mediated inhibition in C. elegans. The EMBO Journal 2011, 30: 1852-1863. PMID: 21427702, PMCID: PMC3101993, DOI: 10.1038/emboj.2011.83.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedAnion Transport ProteinsBrainCaenorhabditis elegansCaenorhabditis elegans ProteinsChloridesElectrophysiologyGene Expression RegulationHydrogen-Ion ConcentrationMicroscopyMotor ActivityMutationNeuronsOocytesPlasmidsReceptors, GABA-ASymportersTransgenesXenopusConceptsCaenorhabditis elegans mutantC. elegansSynapse developmentInhibits cellBehavioral defectsCl- gradientGABAA receptor-mediated inhibitionMutantsReceptor-mediated inhibitionTransportersChloride transportersCl- channelsIdentified mutationsNeuronal expressionCl(-) cotransporterCl(-) extruderInhibitory neurotransmissionChloride gradientChloride influxElegansCellsSevere disruptionCL flowNeural activityPrincipal mechanism
1994
Apical membrane Cl-butyrate exchange: Mechanism of short chain fatty acid stimulation of active chloride absorption in rat distal colon
Rajendran V, Binder H. Apical membrane Cl-butyrate exchange: Mechanism of short chain fatty acid stimulation of active chloride absorption in rat distal colon. The Journal Of Membrane Biology 1994, 141: 51-58. PMID: 7966245, DOI: 10.1007/bf00232873.Peer-Reviewed Original ResearchConceptsRat distal colonFatty acid stimulationDistal colonShort-chain fatty acidsNa-H exchangeActive chloride absorptionHalf maximal inhibitory concentrationAcid stimulationApical membrane vesiclesChain fatty acidsChloride absorptionFatty acid exchangeCl- gradientInhibitory concentrationOutward Cl gradientButyrate concentrationExtravesicular ClColonCellular modelMembrane vesiclesFatty acidsStimulationFunctional NaDisulfonic acidCompelling evidence
1987
Evidence for carrier-mediated Cl-SO4 exchange in rabbit ileal basolateral membrane vesicles
Schron CM, Knickelbein RG, Aronson PS, Dobbins JW. Evidence for carrier-mediated Cl-SO4 exchange in rabbit ileal basolateral membrane vesicles. American Journal Of Physiology 1987, 253: g404-g410. PMID: 3631275, DOI: 10.1152/ajpgi.1987.253.3.g404.Peer-Reviewed Original ResearchConceptsCl- gradient
1986
Na+/HCO3-co-transport in basolateral membrane vesicles isolated from rabbit renal cortex.
Grassl SM, Aronson PS. Na+/HCO3-co-transport in basolateral membrane vesicles isolated from rabbit renal cortex. Journal Of Biological Chemistry 1986, 261: 8778-8783. PMID: 3013862, DOI: 10.1016/s0021-9258(19)84448-4.Peer-Reviewed Original ResearchOxalate transport by anion exchange across rabbit ileal brush border.
Knickelbein RG, Aronson PS, Dobbins JW. Oxalate transport by anion exchange across rabbit ileal brush border. Journal Of Clinical Investigation 1986, 77: 170-175. PMID: 3003149, PMCID: PMC423323, DOI: 10.1172/jci112272.Peer-Reviewed Original ResearchConceptsInside-alkaline pH gradientOxalate uptakeBrush border membraneCl- gradientRabbit ileal brush borderBrush borderIleal brush borderBrush border componentFivefold accumulationFourfold accumulationBorder membraneAbsence of HCO3Alkaline pH gradientRabbit ileumHCO3- exchangeDensity gradient centrifugationBasolateral components
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