2013
Rapid detection of carbapenemase activity through monitoring ertapenem hydrolysis in Enterobacteriaceae with LCMS/MS
Peaper DR, Kulkarni MV, Tichy AN, Jarvis M, Murray TS, Hodsdon ME. Rapid detection of carbapenemase activity through monitoring ertapenem hydrolysis in Enterobacteriaceae with LCMS/MS. Bioanalysis 2013, 5: 147-157. PMID: 23330558, PMCID: PMC5753620, DOI: 10.4155/bio.12.310.Peer-Reviewed Original ResearchConceptsLife-threatening infectionsIll patientsGram-negative rodsDiagnostic testsExpression of carbapenemasesAvailable diagnostic testsRapid diagnostic testsRatios of metabolitesLC-MS/MSCarbapenemase activityHodge testCarbapenem resistanceCarbapenemase productionCarbapenem antibioticsΒ-lactam antibioticsThreshold cutoffDA increaseErtapenem hydrolysisLC-MS/MS methodPatientsClinical laboratoriesAntibioticsLCMS/MSInfectionPhysiological levels
2012
ATP activates P2X receptors to mediate gap junctional coupling in the cochlea
Zhu Y, Zhao H. ATP activates P2X receptors to mediate gap junctional coupling in the cochlea. Biochemical And Biophysical Research Communications 2012, 426: 528-532. PMID: 22982314, PMCID: PMC3471361, DOI: 10.1016/j.bbrc.2012.08.119.Peer-Reviewed Original ResearchConceptsP2X receptorsGap junctional couplingCochlear gap junctionsP2Y receptor agonist UTPGap junctionsJunctional couplingP2X receptor antagonistMetabotropic purinergic receptorsReceptor agonist UTPStimulation of ATPPhysiological levelsReceptor antagonistP2Y receptorsPurinergic controlPurinergic receptorsBenzoylbenzoyl-ATPNoise stressReceptorsIonic homeostasisCochleaDisulfonic acidCritical roleIntercellular channelsATPCells
2009
E6AP promotes the degradation of the PML tumor suppressor
Louria-Hayon I, Alsheich-Bartok O, Levav-Cohen Y, Silberman I, Berger M, Grossman T, Matentzoglu K, Jiang Y, Muller S, Scheffner M, Haupt S, Haupt Y. E6AP promotes the degradation of the PML tumor suppressor. Cell Death & Differentiation 2009, 16: 1156-1166. PMID: 19325566, DOI: 10.1038/cdd.2009.31.Peer-Reviewed Original ResearchConceptsPML-NBsNuclear bodiesTumor suppressorPromyelocytic leukemia (PML) tumor suppressorE3 ligase E6APPML tumor suppressorPML nuclear bodiesPML protein expressionUbiquitination assaysCertain human cancersStress signalsPML proteinImportant regulatorPML stabilityDNA damageE6APCell typesHuman cancersProtein expressionActive formNull micePhysiological levelsSuppressorGrowth inhibitionPML
2005
Microtubule Associated Protein (MAP)-Tau: A Novel Mediator of Paclitaxel Sensitivity In Vitro and In Vivo
Wagner P, Wang B, Clark E, Lee H, Rouzier R, Pusztai L. Microtubule Associated Protein (MAP)-Tau: A Novel Mediator of Paclitaxel Sensitivity In Vitro and In Vivo. Cell Cycle 2005, 4: 1149-1152. PMID: 16103753, DOI: 10.4161/cc.4.9.2038.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingBreast NeoplasmsCell Line, TumorDown-RegulationDrug Resistance, NeoplasmGene Expression RegulationHumansImmunohistochemistryIn Vitro TechniquesInhibitory Concentration 50Microtubule-Associated ProteinsMicrotubulesModels, BiologicalOligonucleotide Array Sequence AnalysisPaclitaxelRNA, MessengerRNA, Small Interferingtau ProteinsTubulinConceptsPaclitaxel sensitivityHuman breast cancer tissuesBreast cancer tissuesHuman breast cancerRole of tauCell linesRegulation of tauBreast cancerCancer tissuesProtein tauNovel markerLow expressionMicrotubule associated proteinNovel mediatorPaclitaxelTauPhysiological levelsGene expression analysisRecent findingsMediatorsMarkersAssociated proteinsChemotherapyCancerExpression analysis
2000
Proton Block and Voltage Gating Are Potassium-dependent in the Cardiac Leak Channel Kcnk3*
Lopes C, Gallagher P, Buck M, Butler M, Goldstein S. Proton Block and Voltage Gating Are Potassium-dependent in the Cardiac Leak Channel Kcnk3*. Journal Of Biological Chemistry 2000, 275: 16969-16978. PMID: 10748056, DOI: 10.1074/jbc.m001948200.Peer-Reviewed Original ResearchConceptsExternal potassium levelsGenomic structureUnique functional attributesProton blockIndependent molecular entitiesP domainMurine examplesFunctional attributesBiophysical propertiesPhysiological voltage rangePhysiological levelsPotassium channelsLeak conductanceMolecular entitiesSubunitsPotassium leak conductanceKCNK3Conductance
1999
Olfactory Adaptation Depends on the Trp Ca2+Channel in Drosophila
Störtkuhl K, Hovemann B, Carlson J. Olfactory Adaptation Depends on the Trp Ca2+Channel in Drosophila. Journal Of Neuroscience 1999, 19: 4839-4846. PMID: 10366618, PMCID: PMC6782652, DOI: 10.1523/jneurosci.19-12-04839.1999.Peer-Reviewed Original Research
1998
Codistribution of TAP and the granule membrane protein GRAMP-92 in rat caerulein-induced pancreatitis
Otani T, Chepilko S, Grendell J, Gorelick F. Codistribution of TAP and the granule membrane protein GRAMP-92 in rat caerulein-induced pancreatitis. American Journal Of Physiology 1998, 275: g999-g1009. PMID: 9815030, DOI: 10.1152/ajpgi.1998.275.5.g999.Peer-Reviewed Original ResearchConceptsAcinar cell compartmentNumber of vesiclesRecycling endosomesSupranuclear compartmentPancreatic acinar cellsTime-dependent mannerProcessing siteCell compartmentTrypsinogen processingPhysiological levelsZymogen granulesImmunofluorescence studiesCaerulein-induced pancreatitisAcinar cellsActivation peptideTrypsinogen activation peptidePathological activationCompartmentsActivation
1993
Sex determination in flowering plants.
Dellaporta S, Calderon-Urrea A. Sex determination in flowering plants. The Plant Cell 1993, 5: 1241-1251. PMID: 8281039, PMCID: PMC160357, DOI: 10.1105/tpc.5.10.1241.Peer-Reviewed Original ResearchConceptsSex determinationSex determination genesFloral organ primordiaExcellent model systemDetermination genesHomeotic genesOrgan primordiaUnisexual flowersPlant speciesHormone signalingFloral developmentSexual determinationMolecular biologyGenesNovel mechanismPlantsUnifying mechanismModel systemPhysiological levelsMechanism of actionUnique systemDioecyMonoecyPrimordiaFlowers
1987
Response of collecting tubule cells to aldosterone and potassium loading
Kashgarian M, Ardito T, Hirsch D, Hayslett J. Response of collecting tubule cells to aldosterone and potassium loading. American Journal Of Physiology 1987, 253: f8-f14. PMID: 3605352, DOI: 10.1152/ajprenal.1987.253.1.f8.Peer-Reviewed Original ResearchConceptsInitial collecting tubuleCortical collecting tubuleBasolateral membrane surfaceCollecting tubuleChronic potassium loadingElevated levelsDuct structuresPotassium loadingSite of actionPlasma levelsRat modelOuter stripeInner stripeTubule cellsNormal physiological levelsControl valuesAldoMorphometric studyAldosteronePhysiological levelsDuct systemTubulesConcomitant changesDuct
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