2008
NaV1.7 Gain-of-Function Mutations as a Continuum: A1632E Displays Physiological Changes Associated with Erythromelalgia and Paroxysmal Extreme Pain Disorder Mutations and Produces Symptoms of Both Disorders
Estacion M, Dib-Hajj SD, Benke PJ, Morsche R, Eastman EM, Macala LJ, Drenth JP, Waxman SG. NaV1.7 Gain-of-Function Mutations as a Continuum: A1632E Displays Physiological Changes Associated with Erythromelalgia and Paroxysmal Extreme Pain Disorder Mutations and Produces Symptoms of Both Disorders. Journal Of Neuroscience 2008, 28: 11079-11088. PMID: 18945915, PMCID: PMC6671384, DOI: 10.1523/jneurosci.3443-08.2008.Peer-Reviewed Original ResearchMeSH KeywordsAlanineAnimalsAnimals, NewbornCells, CulturedChildDose-Response Relationship, RadiationElectric StimulationErythromelalgiaGanglia, SpinalGlutamic AcidHumansMaleMembrane PotentialsModels, MolecularMutationNAV1.7 Voltage-Gated Sodium ChannelNeuronsPatch-Clamp TechniquesRatsRats, Sprague-DawleySodium ChannelsSomatoform DisordersTime FactorsTransfectionConceptsParoxysmal extreme pain disorderDorsal root gangliaTrigeminal ganglion neuronsClinical phenotypeGanglion neuronsMixed clinical phenotypePersistent inward currentsFunction mutationsPatch-clamp analysisPEPD mutationsPain disordersFast inactivationRoot gangliaInward currentsDistinct disordersCurrent clampErythromelalgiaDisordersPainChannel functionVoltage dependencePhysiological changesNeuronsIEMPhenotypeATP activates P2x receptors and requires extracellular Ca++ participation to modify outer hair cell nonlinear capacitance
Yu N, Zhao H. ATP activates P2x receptors and requires extracellular Ca++ participation to modify outer hair cell nonlinear capacitance. Pflügers Archiv - European Journal Of Physiology 2008, 457: 453-461. PMID: 18491132, PMCID: PMC5531446, DOI: 10.1007/s00424-008-0522-5.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAdenosine TriphosphateAnimalsCalciumChelating AgentsEgtazic AcidElectric CapacitanceGuinea PigsHair Cells, Auditory, OuterMembrane PotentialsPatch-Clamp TechniquesPotassiumPurinergic P2 Receptor AntagonistsPyridoxal PhosphateReceptors, Purinergic P2Signal TransductionSodiumSuraminTime FactorsUridine TriphosphateConceptsP2X receptorsATP effectP2Y receptor agonistsMetabotropic purinergic receptorsActive cochlear amplifierEffect of ATPReceptor agonistHearing functionP2Y receptorsPurinergic receptorsDisulfonic acidImportant mediatorReceptorsCell functionOuter hair cell electromotilityHair cell electromotilityIonotropic purinergicCochlear amplifierOHC electromotilityTetraacetic acidATPAgonistsPurinergicVoltage dependenceSuramin
2004
Excitotoxicity
Lipton S. Excitotoxicity. 2004, 291-313. DOI: 10.1002/3527603867.ch14.Peer-Reviewed Original Research
2002
Tuning FlaSh: Redesign of the Dynamics, Voltage Range, and Color of the Genetically Encoded Optical Sensor of Membrane Potential
Guerrero G, Siegel M, Roska B, Loots E, Isacoff E. Tuning FlaSh: Redesign of the Dynamics, Voltage Range, and Color of the Genetically Encoded Optical Sensor of Membrane Potential. Biophysical Journal 2002, 83: 3607-3618. PMID: 12496128, PMCID: PMC1302436, DOI: 10.1016/s0006-3495(02)75361-7.Peer-Reviewed Original ResearchMeSH KeywordsBiosensing TechniquesFluorescence Resonance Energy TransferGreen Fluorescent ProteinsLuminescent ProteinsMembrane PotentialsMicroscopy, FluorescenceMutagenesis, Site-DirectedNeuronsOptics and PhotonicsPotassium ChannelsPotassium Channels, Voltage-GatedProtein EngineeringRecombinant Fusion ProteinsShaker Superfamily of Potassium ChannelsConceptsDetector domainDual-wavelength measurementVoltage-gated ShakerWavelength measurementsOptical readoutOptical sensorsSpectral shiftElectrical signalsIntensity changesDistinct spectraFlashesReadoutSpectraFluorescence intensity changesVoltage dependenceDependenceVoltage rangeMeasurementsSensorsDistinct voltageVoltageDynamicsShift
2001
Casein Kinase 2 Determines the Voltage Dependence of the Kv3.1 Channel in Auditory Neurons and Transfected Cells
Macica C, Kaczmarek L. Casein Kinase 2 Determines the Voltage Dependence of the Kv3.1 Channel in Auditory Neurons and Transfected Cells. Journal Of Neuroscience 2001, 21: 1160-1168. PMID: 11160386, PMCID: PMC6762230, DOI: 10.1523/jneurosci.21-04-01160.2001.Peer-Reviewed Original ResearchMeSH KeywordsAlkaline PhosphataseAnimalsAuditory PathwaysBinding SitesBrain StemCasein Kinase IICDC2-CDC28 KinasesCHO CellsCricetinaeCyclin-Dependent Kinase 2Cyclin-Dependent KinasesElectric StimulationEnzyme InhibitorsIn Vitro TechniquesMembrane PotentialsNeuronsNeuropeptidesPatch-Clamp TechniquesPhosphorylationPotassium ChannelsPotassium Channels, Voltage-GatedPrecipitin TestsProtein Kinase CProtein Serine-Threonine KinasesRatsShaw Potassium ChannelsTetradecanoylphorbol AcetateTransfectionConceptsCasein kinase 2Kinase 2Casein kinase IIProtein kinase CKv3.1 channelsChinese hamster ovary cellsHamster ovary cellsConstitutive phosphorylationPhosphatase treatmentKinase IIKinase CTransfected CellsVoltage-dependent activationOvary cellsWhole-cell conductancePhosphorylationPotassium channelsRectifier channelsBiophysical characteristicsInactivationKv3.1 potassium channelVoltage dependenceActivationKv3.1Patch-clamp recordings
2000
Voltage- and Tension-Dependent Lipid Mobility in the Outer Hair Cell Plasma Membrane
Oghalai J, Zhao H, Kutz J, Brownell W. Voltage- and Tension-Dependent Lipid Mobility in the Outer Hair Cell Plasma Membrane. Science 2000, 287: 658-661. PMID: 10650000, PMCID: PMC1976274, DOI: 10.1126/science.287.5453.658.Peer-Reviewed Original ResearchConceptsCell plasma membranePlasma membraneMembrane tensionOuter hair cell plasma membraneLipid-protein interactionsMembrane fluidityForce-generating motorsMammalian hearingLipid mobilityLipid lateral diffusionHair cellsOuter hair cellsCell depolarizationExquisite sensitivityMembraneLateral diffusionMedium osmolalityHyposmotic challengeCellsDynamic changesTransmembraneElectromotilityFluidityVoltage dependenceDrugs results
1998
Effects of membrane potential on the voltage dependence of motility‐related charge in outer hair cells of the guinea‐pig
Santos‐Sacchi J, Kakehata S, Takahashi S. Effects of membrane potential on the voltage dependence of motility‐related charge in outer hair cells of the guinea‐pig. The Journal Of Physiology 1998, 510: 225-235. PMID: 9625879, PMCID: PMC2231020, DOI: 10.1111/j.1469-7793.1998.225bz.x.Peer-Reviewed Original Research
1997
Molecular dissection of gating in the ClC‐2 chloride channel
Jordt S, Jentsch T. Molecular dissection of gating in the ClC‐2 chloride channel. The EMBO Journal 1997, 16: 1582-1592. PMID: 9130703, PMCID: PMC1169762, DOI: 10.1093/emboj/16.7.1582.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell MembraneChloride ChannelsConsensus SequenceHydrogen-Ion ConcentrationIon Channel GatingMembrane PotentialsModels, StructuralMolecular Sequence DataMutagenesis, Site-DirectedOocytesPatch-Clamp TechniquesPoint MutationProtein Structure, SecondaryRatsRecombinant Fusion ProteinsXenopus laevisConceptsChloride channelsClC-2 chloride channelSite-directed mutagenesisMolecular dissectionEquivalent mutationCytoplasmic loopMode of activationClC-0ClC-2Gating mechanismInactivation domainMutationsCell swellingActivationNeuronal excitabilityMutagenesisTransmembraneCell volumeDeletionRegulationPathwayFinal pathwayMechanismVoltage dependenceOutward rectification
1994
A shab potassium channel contributes to action potential broadening in peptidergic neurons
Quattrocki E, Marshall J, Kaczmarek L. A shab potassium channel contributes to action potential broadening in peptidergic neurons. Neuron 1994, 12: 73-86. PMID: 8292361, DOI: 10.1016/0896-6273(94)90153-8.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAmino Acid SequenceAnimalsAplysiaBase SequenceCloning, MolecularDNA, ComplementaryFemaleInvertebrate HormonesKineticsMathematicsModels, TheoreticalMolecular Sequence DataNeuronsOocytesPolymerase Chain ReactionPotassiumPotassium ChannelsShab Potassium ChannelsTetraethylammoniumTetraethylammonium CompoundsTranscription, GeneticXenopus laevis
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply