H19 lncRNA alters methylation and expression of Hnf4α in the liver of metformin-exposed fetuses
Deng J, Mueller M, Geng T, Shen Y, Liu Y, Hou P, Ramillapalli R, Taylor HS, Paidas M, Huang Y. H19 lncRNA alters methylation and expression of Hnf4α in the liver of metformin-exposed fetuses. Cell Death & Disease 2017, 8: e3175-e3175. PMID: 29215608, PMCID: PMC5827203, DOI: 10.1038/cddis.2017.392.Peer-Reviewed Original ResearchMeSH KeywordsAdenosylhomocysteinaseAnimalsBase SequenceCell Line, TumorFemaleFetusGene Expression ProfilingGene Expression RegulationGluconeogenesisHepatocyte Nuclear Factor 4HepatocytesHumansHypoglycemic AgentsLiverMaleMaternal ExposureMetforminMethylationMicePregnancyPrenatal Exposure Delayed EffectsRNA, Long NoncodingSignal TransductionConceptsFetal liverPrenatal metformin exposureAnti-diabetic medicationsHuman liver cell lineHepatocyte nuclear factor 4αNuclear factor 4αMetabolic abnormalitiesMetformin exposureLiver cell lineH19 overexpressionMetabolic disordersAdult offspringFetal originAnimal studiesH19 expressionMouse fetusesMetforminElevated expressionLiverConcomitant activationCell linesFetusesGluconeogenic genesS-adenosylhomocysteine hydrolaseLiver development
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