2020
Effects of Metformin Exposure on Survival in a Large National Cohort of Patients With Diabetes and Cirrhosis
Kaplan DE, Serper M, John BV, Tessiatore KM, Lerer R, Mehta R, Fox R, Aytaman A, Baytarian M, Hunt K, Albrecht J, Taddei TH, Group V. Effects of Metformin Exposure on Survival in a Large National Cohort of Patients With Diabetes and Cirrhosis. Clinical Gastroenterology And Hepatology 2020, 19: 2148-2160.e14. PMID: 32798709, DOI: 10.1016/j.cgh.2020.08.026.Peer-Reviewed Original ResearchConceptsDiagnosis of cirrhosisEnzyme inhibitors/angiotensinMetformin exposureHepatic decompensationHepatocellular carcinomaDiabetes mellitusPrognosis of cirrhosisPropensity-matched approachPre-existing diabetesRetrospective cohort studyLarge national cohortVeterans Health AdministrationMarginal structural modelsConcomitant statinCohort studyMultiple medicationsStatin exposureNational cohortCirrhosisPatientsDiabetesDecompensationMetforminConcomitant exposureHealth Administration
2017
H19 lncRNA alters methylation and expression of Hnf4α in the liver of metformin-exposed fetuses
Deng J, Mueller M, Geng T, Shen Y, Liu Y, Hou P, Ramillapalli R, Taylor HS, Paidas M, Huang Y. H19 lncRNA alters methylation and expression of Hnf4α in the liver of metformin-exposed fetuses. Cell Death & Disease 2017, 8: e3175-e3175. PMID: 29215608, PMCID: PMC5827203, DOI: 10.1038/cddis.2017.392.Peer-Reviewed Original ResearchMeSH KeywordsAdenosylhomocysteinaseAnimalsBase SequenceCell Line, TumorFemaleFetusGene Expression ProfilingGene Expression RegulationGluconeogenesisHepatocyte Nuclear Factor 4HepatocytesHumansHypoglycemic AgentsLiverMaleMaternal ExposureMetforminMethylationMicePregnancyPrenatal Exposure Delayed EffectsRNA, Long NoncodingSignal TransductionConceptsFetal liverPrenatal metformin exposureAnti-diabetic medicationsHuman liver cell lineHepatocyte nuclear factor 4αNuclear factor 4αMetabolic abnormalitiesMetformin exposureLiver cell lineH19 overexpressionMetabolic disordersAdult offspringFetal originAnimal studiesH19 expressionMouse fetusesMetforminElevated expressionLiverConcomitant activationCell linesFetusesGluconeogenic genesS-adenosylhomocysteine hydrolaseLiver development
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