2023
Head and neck follicular lymphoma with marginal zone differentiation and BCL2 translocation t(14;18) in both nodular and extranodular sites: a case report with mini-review
Vageli D, Doukas P, Batrakouli O, Tsangari V, Zacharouli K, Pouliou E, Tzika S, Ioannou M. Head and neck follicular lymphoma with marginal zone differentiation and BCL2 translocation t(14;18) in both nodular and extranodular sites: a case report with mini-review. Oral Surgery Oral Medicine Oral Pathology And Oral Radiology 2023, 136: e139-e148. PMID: 37516620, DOI: 10.1016/j.oooo.2023.05.005.Peer-Reviewed Original ResearchConceptsFollicular lymphomaMarginal zone differentiationGerminal centersB cellsParotid glandFollicular dendritic cell markersSame B-cell cloneBCL2 translocationDendritic cell markersBone marrow biopsyProliferative B cellsB cell clonesBCL2/IGHCase reportRare caseCell markersZone differentiationLymphomaParotidBCL6GlandDifferentiated cellsHeadDifferentiationMolecular analysis
2017
Cellular differentiation state modulates the mRNA export activity of SR proteins
Botti V, McNicoll F, Steiner MC, Richter FM, Solovyeva A, Wegener M, Schwich OD, Poser I, Zarnack K, Wittig I, Neugebauer KM, Müller-McNicoll M. Cellular differentiation state modulates the mRNA export activity of SR proteins. Journal Of Cell Biology 2017, 216: 1993-2009. PMID: 28592444, PMCID: PMC5496613, DOI: 10.1083/jcb.201610051.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAnimalsArginineCell DifferentiationCell NucleusDNA-Binding ProteinsHeLa CellsHumansImmunoprecipitationMethylationMiceNeurogenesisPhenotypePhosphorylationPluripotent Stem CellsProtein BindingProtein Processing, Post-TranslationalRepressor ProteinsRNA InterferenceRNA-Binding ProteinsRNA, MessengerSerine-Arginine Splicing FactorsTandem Mass SpectrometryTranscription FactorsTransfectionConceptsMRNA export activitySR proteinsP19 cellsMRNA exportSR protein family membersProtein-RNA interactionsMurine P19 cellsCellular differentiation stateProtein family membersLower phosphorylation levelsArginine methylationPluripotency factorsCytoplasmic mRNA levelsMRNA processingPosttranslational modificationsCellular dynamicsDifferentiated cellsNeural differentiationSRSF5Differentiation statePhosphorylation levelsHeLa cellsProteinExport activityMRNA levelsTissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice
Park S, Gonzalez DG, Guirao B, Boucher JD, Cockburn K, Marsh ED, Mesa KR, Brown S, Rompolas P, Haberman AM, Bellaïche Y, Greco V. Tissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice. Nature Cell Biology 2017, 19: 155-163. PMID: 28248302, PMCID: PMC5581297, DOI: 10.1038/ncb3472.Peer-Reviewed Original ResearchTissue-scale organizationEpidermal wound repairRegional coexistenceCellular behaviorDifferentiated cellsEpithelial behaviorUndamaged cellsProliferation functionTissue architectureHomeostatic functionsDifferentiation changesLive mammalsLive miceWound repairTissue repairProliferative zoneHomeostatic behaviorCellsSkin repairSpatiotemporal dynamicsMammalsWoundsMiceRepairMigrationMicrotubule‐regulating proteins and cAMP‐dependent signaling in neuroblastoma differentiation
Muñoz‐Llancao P, de Gregorio C, Heras M, Meinohl C, Noorman K, Boddeke E, Cheng X, Lezoualc'h F, Schmidt M, Gonzalez‐Billault C. Microtubule‐regulating proteins and cAMP‐dependent signaling in neuroblastoma differentiation. Cytoskeleton 2017, 74: 143-158. PMID: 28164467, DOI: 10.1002/cm.21355.Peer-Reviewed Original ResearchConceptsMicrotubule-regulating proteinsN1E-115 cellsMicrotubule-stabilizing factorsDifferentiation of N1E-115 neuroblastoma cellsPKA-AKAP interactionsMicrotubule-destabilizing proteinNeuroblastoma cellsEpac-dependent signalingFunctions of EPACDifferentiated neuroblastoma cellsInduce neuronal differentiationCAMP-dependent signalingN1E-115Analog of cyclic AMPN1E-115 neuroblastoma cellsIntracellular domainMicrotubule stabilityDb-cAMPCell biologyCell differentiationEpac activationNeuroblastoma differentiationNeuronal differentiationDifferentiated cellsNeuronal cellsActivity of Retrotransposons in Stem Cells and Differentiated Cells
Macia A, Tejwani L, Mesci P, Muotri A, Garcia-Perez J. Activity of Retrotransposons in Stem Cells and Differentiated Cells. 2017, 127-156. DOI: 10.1007/978-3-319-48344-3_6.Peer-Reviewed Original ResearchTransposable elementsSelfish DNAHuman genomeTE insertionsEarly embryonic developmental stagesActivity of TEsActivity of retrotransposonsActivity of L1New TE insertionsEmbryonic developmental stagesHuman transposable elementsMammalian genomesGenome stabilityEukaryotic genomesNew genesGenomic regulationGenomic rearrangementsGenomeLINE-1sDifferentiated cellsGerm cellsDevelopmental stagesMobile elementsNew copiesStem cells
2016
miR-200 family promotes podocyte differentiation through repression of RSAD2
Li Z, Yin H, Hao S, Wang L, Gao J, Tan X, Yang Z. miR-200 family promotes podocyte differentiation through repression of RSAD2. Scientific Reports 2016, 6: 27105. PMID: 27251424, PMCID: PMC4890021, DOI: 10.1038/srep27105.Peer-Reviewed Original ResearchConceptsMiR-200 familyPodocyte differentiationKidney developmentCell differentiationMiR-200aDifferentiation of podocytesUnderlying molecular mechanismsCellular functionsRNA interferencePostnatal mouse kidneyMolecular mechanismsDifferentiated cellsNovel roleMature podocytesHigher upregulationProtein 2 expressionRSAD2MiR-200bMiR-429DifferentiationPodocyte dedifferentiationRepressionCharacteristic phenotypic featuresPhenotypic featuresMorphological characteristicsMolecular features of cellular reprogramming and development
Smith ZD, Sindhu C, Meissner A. Molecular features of cellular reprogramming and development. Nature Reviews Molecular Cell Biology 2016, 17: 139-154. PMID: 26883001, DOI: 10.1038/nrm.2016.6.Peer-Reviewed Original ResearchConceptsKrüppel-like factor 4Pluripotent stateSRY-box 2Somatic cellsDirect reprogrammingInduced pluripotent stem cell generationDifferentiated cellsPluripotent stem cell generationCis-regulatory elementsStem cell generationAdditional molecular featuresMolecular featuresPluripotent stem cellsChromatin remodellersBivalent chromatinEpigenetic barriersDevelopmental genesCellular identityCellular reprogrammingGenetic modulesEpigenetic regulationCompact chromatinTranscriptional inductionEpigenetic repressorEpigenetic modifiers
2014
Survival and Integration of Neurons Derived from Human Embryonic Stem Cells in MPTP-Lesioned Primates
Wakeman DR, Weiss S, Sladek JR, Elsworth JD, Bauereis B, Leranth C, Hurley PJ, Roth RH, Redmond DE. Survival and Integration of Neurons Derived from Human Embryonic Stem Cells in MPTP-Lesioned Primates. Cell Transplantation 2014, 23: 981-994. PMID: 23562290, DOI: 10.3727/096368913x664865.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cell linesEmbryonic stem cell linesHuman embryonic stem cellsEmbryonic stem cellsGene expression studiesStem cell linesGFP lentiviral vectorExpression studiesDifferentiated cellsDifferentiation protocolsDopamine neuronal survivalIntegration of neuronsNeuronal cellsNeuronal phenotypeTyrosine hydroxylaseStem cellsExtension of processesBiochemical analysisDopaminergic marker tyrosine hydroxylaseHESCCell linesIII-tubulinMidbrain of MPTPPhenotypeMembrane depolarization
2012
Impact of Retrotransposons in Pluripotent Stem Cells
Tanaka Y, Chung L, Park IH. Impact of Retrotransposons in Pluripotent Stem Cells. Molecules And Cells 2012, 34: 509-516. PMID: 23135636, PMCID: PMC3784326, DOI: 10.1007/s10059-012-0242-8.Peer-Reviewed Original ResearchSox2 Acts through Sox21 to Regulate Transcription in Pluripotent and Differentiated Cells
Kuzmichev A, Kim S, D’Alessio A, Chenoweth J, Wittko I, Campanati L, McKay R. Sox2 Acts through Sox21 to Regulate Transcription in Pluripotent and Differentiated Cells. Current Biology 2012, 22: 1705-1710. PMID: 22902753, DOI: 10.1016/j.cub.2012.07.013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCDX2 Transcription FactorCell DifferentiationCell LineColonic NeoplasmsFibroblastsGene Expression RegulationHomeodomain ProteinsIntestinal MucosaIntestinesMiceMice, TransgenicOctamer Transcription Factor-3Pluripotent Stem CellsSOXB1 Transcription FactorsSOXB2 Transcription FactorsTranscription FactorsTranscription, GeneticTranscriptional ActivationConceptsStem cellsImportant transcriptional regulatorStem cell renewalIntestinal stem cellsAdult stem cellsColon cancer cellsEndodermal identityPluripotent stem cellsEffect of SOX2Gene familyCell identityPluripotent stateTranscriptional partnersTranscriptional regulatorsTranscriptional inductionTranscription factorsMaster regulatorTranscriptional actionGene expressionSox21Differentiated cellsCell renewalSOX2General mediatorCell types
2011
Control of cortical microtubule organization and desmosome stability by centrosomal proteins
Sumigray KD, Lechler T. Control of cortical microtubule organization and desmosome stability by centrosomal proteins. BioArchitecture 2011, 1: 221-224. PMID: 22754612, PMCID: PMC3384573, DOI: 10.4161/bioa.18403.Peer-Reviewed Original ResearchDerivation of Insulin Producing Cells From Human Endometrial Stromal Stem Cells and Use in the Treatment of Murine Diabetes
Santamaria X, Massasa EE, Feng Y, Wolff E, Taylor HS. Derivation of Insulin Producing Cells From Human Endometrial Stromal Stem Cells and Use in the Treatment of Murine Diabetes. Molecular Therapy 2011, 19: 2065-2071. PMID: 21878900, PMCID: PMC3222529, DOI: 10.1038/mt.2011.173.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal stem cellsStromal stem cellsPancreatic islet cell transplantationStem cellsIslet cell transplantationType 1 diabetesBlood glucose levelsTreatment of murineDifferentiated cellsDiabetic miceCell transplantationKidney capsuleCadaveric donorsPotential therapeutic applicationsProgressive hyperglycemiaInsulin secretionMurine modelGlucose levelsUterine endometriumMesenchymal stem cellsΒ-cell markersInsulinHuman insulinGlucose-responsive mannerControl cells
2010
MicroRNA Profiling Reveals Two Distinct p53-Related Human Pluripotent Stem Cell States
Neveu P, Kye MJ, Qi S, Buchholz DE, Clegg DO, Sahin M, Park IH, Kim KS, Daley GQ, Kornblum HI, Shraiman BI, Kosik KS. MicroRNA Profiling Reveals Two Distinct p53-Related Human Pluripotent Stem Cell States. Cell Stem Cell 2010, 7: 671-681. PMID: 21112562, DOI: 10.1016/j.stem.2010.11.012.Peer-Reviewed Original ResearchConceptsInduced pluripotent stem cellsPluripotent stem cell stateEmbryonic stem cellsStem cell stateCell statesDifferentiated cellsStem cellsCell linesPluripotent stem cellsHuman cell linesGene setsMiRNA expression levelsMiR-92Cell line originMicroRNA profilingCancer cell linesLine originMiRNA profilesExpression levelsPluripotencyCancer cellsMiR-141CellsSubtle differencesHESCsHomologous Recombination Conserves DNA Sequence Integrity Throughout the Cell Cycle in Embryonic Stem Cells
Serrano L, Liang L, Chang Y, Deng L, Maulion C, Nguyen S, Tischfield JA. Homologous Recombination Conserves DNA Sequence Integrity Throughout the Cell Cycle in Embryonic Stem Cells. Stem Cells And Development 2010, 20: 363-374. PMID: 20491544, PMCID: PMC3128761, DOI: 10.1089/scd.2010.0159.Peer-Reviewed Original ResearchConceptsDouble-strand breaksGerm cell lineageHomologous recombinationCell lineagesDifferentiated cellsMajor DSB repair pathwaysImportant genetic consequencesDNA sequence integrityHR-mediated repairDNA damage repair mechanismsFrequent homologous recombinationSpontaneous DNA damageDSB repair pathwaysStem cellsEmbryonic stem cellsDamage repair mechanismsGenome integrityGenetic consequencesGenomic integrityHomologous chromosomesUndesirable mutationsLow mutation frequencyChromosome sequencesRepair fociPathway choiceUtility of Telomerase-pot1 Fusion Protein in Vascular Tissue Engineering
Petersen TH, Hitchcock T, Muto A, Calle EA, Zhao L, Gong Z, Gui L, Dardik A, Bowles DE, Counter CM, Niklason LE. Utility of Telomerase-pot1 Fusion Protein in Vascular Tissue Engineering. Cell Transplantation 2010, 19: 79-87. PMID: 19878625, PMCID: PMC2850951, DOI: 10.3727/096368909x478650.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAdultAnimalsBioreactorsBlood VesselsCell Culture TechniquesCells, CulturedCellular SenescenceCollagenGenetic VectorsGraft SurvivalHumansMaleMuscle, Smooth, VascularRatsRats, NudeRecombinant Fusion ProteinsShelterin ComplexTelomeraseTelomere-Binding ProteinsTissue EngineeringTransfectionConceptsTransient deliveryVascular tissue engineeringRegenerative medicineTissue engineeringRegenerative medicine applicationsTissue-engineered constructsLentiviral vectorsMedicine applicationsImportant stumbling blockTelomeric repeat amplification protocolElderly human donorsBetter performanceAmplification protocolEngineeringDeliveryTransient reconstitutionDifferentiated cellsAdenoviral deliveryRepeat amplification protocolFusion proteinTransgeneHuman smooth muscle cellsStumbling blockGreater collagen contentProtocol
2009
Differentiation of Human Neural Progenitor Cells on PLGA Microfibers
Hwang C, Kim S, Kim J, Khademhosseini A, Lee S. Differentiation of Human Neural Progenitor Cells on PLGA Microfibers. 2009, 1: 1-2. DOI: 10.1109/nebc.2009.4967758.Peer-Reviewed Original ResearchHuman embryonic stem cellsNeural progenitor cellsEmbryoid bodiesMicrofluidic spinning systemPLGA microfibersNeural tissue regenerationEmbryonic stem cellsNeural tissue engineeringProgenitor cellsHuman neural progenitor cellsTissue engineeringNeuronal protein expressionNeural progenitor markersGlial fibrillary acidic proteinMicrofibersTissue regenerationNascent fibersPLGA fibersNeural progenitorsDifferentiated cellsCell differentiationProgenitor markersStem cellsGuidance cuesProtein expression
2008
Reprogramming of Pancreatic β Cells into Induced Pluripotent Stem Cells
Stadtfeld M, Brennand K, Hochedlinger K. Reprogramming of Pancreatic β Cells into Induced Pluripotent Stem Cells. Current Biology 2008, 18: 890-894. PMID: 18501604, PMCID: PMC2819222, DOI: 10.1016/j.cub.2008.05.010.Peer-Reviewed Original ResearchConceptsEmbryonic stem cellsPluripotent stem cellsCell typesIPS cellsStem cellsC-MycTranscription factors Oct4Rare cell typesInduced pluripotent stem cellsCertain cell typesAdult stem cellsInducible lentivirusVitro reprogrammingFactors OCT4Pluripotent cellsEctopic expressionGenetic proofPancreatic β-cellsGerm layersDifferentiated cellsChimeric animalsPluripotency markersDifferentiation stageBeta cellsPancreatic beta cells
2007
Neuronal and astrocytic cells, obtained after differentiation of human neural GFAP-positive progenitors, present heterogeneous expression of PrPc
Witusik M, Gresner S, Hulas-Bigoszewska K, Krynska B, Azizi S, Liberski P, Brown P, Rieske P. Neuronal and astrocytic cells, obtained after differentiation of human neural GFAP-positive progenitors, present heterogeneous expression of PrPc. Brain Research 2007, 1186: 65-73. PMID: 17996224, DOI: 10.1016/j.brainres.2007.10.039.Peer-Reviewed Original ResearchConceptsProgenitor cellsCharacteristics of stem/progenitor cellsCell differentiationMultiplex PCR assayNeuronal cellsExpression of PrPcExpression of PrP(CCellular isoformGFAP-positive cellsIn vitro modelIn vivo studiesUndifferentiated cell populationsPrion proteinWestern blot analysisStem/progenitor cellsHeterogeneous expressionGlial cellsDifferentiated cellsPhysiological roleCell populationsBlot analysisHuman neurogenesisAstrocytic cellsExpression levelsIn vitroNuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation
Mullen EM, Gu P, Cooney AJ. Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation. PPAR Research 2007, 2007: 61563. PMID: 18274628, PMCID: PMC2233893, DOI: 10.1155/2007/61563.Peer-Reviewed Original ResearchNuclear receptorsES cellsES cell phenotypeES cell pluripotencyLIF/STAT3Embryonic stem cellsTranscription factor Sox2Different cell typesCell pluripotencyPluripotent phenotypeFactor Sox2Differentiated cellsCell typesStem cellsCell phenotypeGreat therapeutic potentialPhenotypeCellsDifferentiationReceptorsImportant processPluripotency
2006
Multiple Imprinted and Stemness Genes Provide a Link between Normal and Tumor Progenitor Cells of the Developing Human Kidney
Dekel B, Metsuyanim S, Schmidt-Ott KM, Fridman E, Jacob-Hirsch J, Simon A, Pinthus J, Mor Y, Barasch J, Amariglio N, Reisner Y, Kaminski N, Rechavi G. Multiple Imprinted and Stemness Genes Provide a Link between Normal and Tumor Progenitor Cells of the Developing Human Kidney. Cancer Research 2006, 66: 6040-6049. PMID: 16778176, DOI: 10.1158/0008-5472.can-05-4528.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGene Expression ProfilingGenomic ImprintingHomeodomain ProteinsHumansKidneyKidney NeoplasmsMiceMice, Inbred BALB CMice, NudeMice, SCIDMultigene FamilyMyeloid Ecotropic Viral Integration Site 1 ProteinNeoplasm ProteinsNeoplasm TransplantationNeoplastic Stem CellsOligonucleotide Array Sequence AnalysisRatsTransplantation, HeterologousWilms TumorConceptsProgenitor cell populationsRenal progenitor cell populationStemness genesCell populationsNormal kidney developmentAdult mouse kidneyHomeobox genesMetanephric blastemaExpression of Peg3Transcriptional profilingOligonucleotide microarraysKidney developmentDifferentiated cellsCell differentiationHuman fetal kidneyTumor progenitor cellsGenesReal-time PCRMouse nephrogenesisBlastemaWT samplesProgenitor cellsStromal phenotypeWT sourcesPeg3
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