2019
A balanced evaluation of the evidence for adult neurogenesis in humans: implication for neuropsychiatric disorders
Duque A, Spector R. A balanced evaluation of the evidence for adult neurogenesis in humans: implication for neuropsychiatric disorders. Brain Structure And Function 2019, 224: 2281-2295. PMID: 31278571, PMCID: PMC6852840, DOI: 10.1007/s00429-019-01917-6.Peer-Reviewed Original ResearchConceptsAdult human brainAdult neurogenesisHuman brainAdult human neurogenesisNormal neuronal circuitsBrain homeostatic systemsNeural stem cellsDentate gyrusBrain neuronsAdult brainCertain drugsNeuronal circuitsHigher cognitive functionsNeuropsychiatric disordersCognitive functionNeurogenesisHuman neurogenesisBrainHomeostatic systemNeuronsStem cellsRecent studiesPrevention of damageDifferent stimuliHumans
2013
Mutations in CSPP1 Lead to Classical Joubert Syndrome
Akizu N, Silhavy JL, Rosti RO, Scott E, Fenstermaker AG, Schroth J, Zaki MS, Sanchez H, Gupta N, Kabra M, Kara M, Ben-Omran T, Rosti B, Guemez-Gamboa A, Spencer E, Pan R, Cai N, Abdellateef M, Gabriel S, Halbritter J, Hildebrandt F, van Bokhoven H, Gunel M, Gleeson JG. Mutations in CSPP1 Lead to Classical Joubert Syndrome. American Journal Of Human Genetics 2013, 94: 80-86. PMID: 24360807, PMCID: PMC3882909, DOI: 10.1016/j.ajhg.2013.11.015.Peer-Reviewed Original ResearchConceptsJoubert syndromeDistinctive mid-hindbrain malformationMid-hindbrain malformationPrimary cilia dysfunctionPrimary ciliaKidney diseaseLarge cohortVariable involvementRelated disordersHuman neurogenesisNeural tissueProtein levelsAffected individualsSyndromeCilia dysfunctionCohortNeural-specific functionsCausative mutationsMutationsNull mutationCSPP1IndividualsCiliaDysfunctionJSRD
2009
Long‐Term Multilayer Adherent Network (MAN) Expansion, Maintenance, and Characterization, Chemical and Genetic Manipulation, and Transplantation of Human Fetal Forebrain Neural Stem Cells
Wakeman DR, Hofmann MR, Redmond DE, Teng YD, Snyder EY. Long‐Term Multilayer Adherent Network (MAN) Expansion, Maintenance, and Characterization, Chemical and Genetic Manipulation, and Transplantation of Human Fetal Forebrain Neural Stem Cells. Current Protocols In Stem Cell Biology 2009, 9: 2d.3.1-2d.3.77. PMID: 19455542, DOI: 10.1002/9780470151808.sc02d03s9.Peer-Reviewed Original ResearchConceptsCentral nervous system disordersNSC/NPCsNeural stem/precursor cellsNeural stem/progenitor cellsNervous system disordersEarly human neurogenesisStem/precursor cellsSmall molecule drug screeningStem/progenitor cellsForebrain neural stem cellsNeural stem cellsHuman neural stem/precursor cellsAdult rodentsTherapeutic modalitiesParkinson's diseaseSystem disordersCadaveric sourcesMonkey brainAlzheimer's diseaseNeurodegenerative disordersHuman neurogenesisNeuronal migrationDiseaseLong-term maintenanceMigratory capability
2007
Neuronal and astrocytic cells, obtained after differentiation of human neural GFAP-positive progenitors, present heterogeneous expression of PrPc
Witusik M, Gresner S, Hulas-Bigoszewska K, Krynska B, Azizi S, Liberski P, Brown P, Rieske P. Neuronal and astrocytic cells, obtained after differentiation of human neural GFAP-positive progenitors, present heterogeneous expression of PrPc. Brain Research 2007, 1186: 65-73. PMID: 17996224, DOI: 10.1016/j.brainres.2007.10.039.Peer-Reviewed Original ResearchConceptsProgenitor cellsCharacteristics of stem/progenitor cellsCell differentiationMultiplex PCR assayNeuronal cellsExpression of PrPcExpression of PrP(CCellular isoformGFAP-positive cellsIn vitro modelIn vivo studiesUndifferentiated cell populationsPrion proteinWestern blot analysisStem/progenitor cellsHeterogeneous expressionGlial cellsDifferentiated cellsPhysiological roleCell populationsBlot analysisHuman neurogenesisAstrocytic cellsExpression levelsIn vitro
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