2019
LMO7 Is a Negative Feedback Regulator of Transforming Growth Factor β Signaling and Fibrosis
Xie Y, Ostriker AC, Jin Y, Hu H, Sizer AJ, Peng G, Morris AH, Ryu C, Herzog EL, Kyriakides T, Zhao H, Dardik A, Yu J, Hwa J, Martin KA. LMO7 Is a Negative Feedback Regulator of Transforming Growth Factor β Signaling and Fibrosis. Circulation 2019, 139: 679-693. PMID: 30586711, PMCID: PMC6371979, DOI: 10.1161/circulationaha.118.034615.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ProliferationCells, CulturedDisease Models, AnimalExtracellular MatrixFeedback, PhysiologicalFibrosisHyperplasiaIntegrin alphaVbeta3LIM Domain ProteinsMaleMice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaSignal TransductionTranscription Factor AP-1Transcription FactorsTransforming Growth Factor beta1Vascular RemodelingVascular System InjuriesConceptsSmooth muscle cellsActivator protein-1 (AP-1) transcription factorExtracellular matrixProtein-1 transcription factorTransforming Growth Factor β SignalingGrowth factor β signalingMouse smooth muscle cellsTGF-β1 target genesHuman smooth muscle cellsActivator protein-1Muscle-specific deletionNegative feedback regulatorTGF-β pathwayECM protein expressionSmad3 phosphorylationNegative feedback regulationTranscription factorsArteriovenous fistulaECM depositionDomain interactsTGF-β proteinTarget genesLMO7TGF-β treatmentGrowth factor β
2016
Dorsomorphin homologue 1, a highly selective small-molecule bone morphogenetic protein inhibitor, suppresses medial artery calcification
Lin T, Wang XL, Zettervall SL, Cai Y, Guzman RJ. Dorsomorphin homologue 1, a highly selective small-molecule bone morphogenetic protein inhibitor, suppresses medial artery calcification. Journal Of Vascular Surgery 2016, 66: 586-593. PMID: 27374065, PMCID: PMC5201454, DOI: 10.1016/j.jvs.2016.03.462.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAorta, ThoracicAortic DiseasesBone Morphogenetic Protein Receptors, Type IBone Morphogenetic ProteinsCells, CulturedHumansMuscle, Smooth, VascularMyocytes, Smooth MuscleOrgan Culture TechniquesOsteogenesisPhosphatesPyrazolesQuinolinesRats, Sprague-DawleySignal TransductionVascular CalcificationConceptsMedial artery calcificationSmooth muscle cellsArtery calcificationMedial calcificationOrgan culture modelVascular patientsVascular calcificationWestern blotCalcium accumulationHuman aortic smooth muscle cellsChronic kidney diseaseCulture modelVascular smooth muscle cellsAortic smooth muscle cellsQuantitative reverse transcription polymerase chain reactionReverse transcription-polymerase chain reactionSMC markersTranscription-polymerase chain reactionHuman smooth muscle cellsAortic medial calcificationMuscle myosin heavy chainHomologue 1Bone morphogenetic proteinKidney diseasePolymerase chain reactionLipid composition of the myoendothelial junction allows for compartmentalized eNOS function
Biwer L, Taddeo E, Hoehn K, Straub A, Isakson B. Lipid composition of the myoendothelial junction allows for compartmentalized eNOS function. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.727.9.Peer-Reviewed Original ResearchEndothelial nitric oxide synthaseSmooth muscle cellsEndothelial cellsMyoendothelial junctionsResistance arteriesEC endothelial nitric oxide synthaseNeighboring smooth muscle cellsTumor necrosis factor alphaBlood pressure regulationNecrosis factor alphaNitric oxide synthasePKC activityHuman smooth muscle cellsInternal elastic laminaER calcium releaseTHP-1 monocytesCo-cultured endothelial cellsVascular toneENOS functionOxide synthaseFactor alphaGap junction inhibitionLipid compositionDifferential lipid compositionPhenylephrine
2013
Ten-Eleven Translocation-2 (TET2) Is a Master Regulator of Smooth Muscle Cell Plasticity
Liu R, Jin Y, Tang WH, Qin L, Zhang X, Tellides G, Hwa J, Yu J, Martin KA. Ten-Eleven Translocation-2 (TET2) Is a Master Regulator of Smooth Muscle Cell Plasticity. Circulation 2013, 128: 2047-2057. PMID: 24077167, PMCID: PMC3899790, DOI: 10.1161/circulationaha.113.002887.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtherosclerosisCell DifferentiationCells, CulturedDioxygenasesDNA-Binding ProteinsEpigenesis, GeneticHumansKruppel-Like Factor 4Kruppel-Like Transcription FactorsMiceMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleNuclear ProteinsPromoter Regions, GeneticProto-Oncogene ProteinsTrans-ActivatorsWound HealingConceptsTen-Eleven Translocation-2SMC differentiationTET2 knockdownSmooth muscle cellsGene expressionTranslocation 2Smooth Muscle Cell PlasticityMaster epigenetic regulatorSMC gene expressionContractile gene expressionMuscle cell plasticityDedifferentiated smooth muscle cellsTET2 overexpressionContractile smooth muscle cellsHuman smooth muscle cellsChromatin accessibilityEpigenetic landscapeSMC plasticityChromatin immunoprecipitationEpigenetic regulatorsEpigenetic mechanismsCell plasticityMaster regulatorSMC phenotypeTranscriptional upregulation
2010
Utility of Telomerase-pot1 Fusion Protein in Vascular Tissue Engineering
Petersen TH, Hitchcock T, Muto A, Calle EA, Zhao L, Gong Z, Gui L, Dardik A, Bowles DE, Counter CM, Niklason LE. Utility of Telomerase-pot1 Fusion Protein in Vascular Tissue Engineering. Cell Transplantation 2010, 19: 79-87. PMID: 19878625, PMCID: PMC2850951, DOI: 10.3727/096368909x478650.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAdultAnimalsBioreactorsBlood VesselsCell Culture TechniquesCells, CulturedCellular SenescenceCollagenGenetic VectorsGraft SurvivalHumansMaleMuscle, Smooth, VascularRatsRats, NudeRecombinant Fusion ProteinsShelterin ComplexTelomeraseTelomere-Binding ProteinsTissue EngineeringTransfectionConceptsTransient deliveryVascular tissue engineeringRegenerative medicineTissue engineeringRegenerative medicine applicationsTissue-engineered constructsLentiviral vectorsMedicine applicationsImportant stumbling blockTelomeric repeat amplification protocolElderly human donorsBetter performanceAmplification protocolEngineeringDeliveryTransient reconstitutionDifferentiated cellsAdenoviral deliveryRepeat amplification protocolFusion proteinTransgeneHuman smooth muscle cellsStumbling blockGreater collagen contentProtocol
1992
Scatter factor and hepatocyte growth factor: activities, properties, and mechanism.
Bhargava M, Joseph A, Knesel J, Halaban R, Li Y, Pang S, Goldberg I, Setter E, Donovan M, Zarnegar R. Scatter factor and hepatocyte growth factor: activities, properties, and mechanism. Molecular Cancer Research 1992, 3: 11-20. PMID: 1534687.Peer-Reviewed Original ResearchConceptsHepatocyte growth factorScatter factorPartial amino acid sequence dataAmino acid sequence dataAmino acid sequenceFibroblast-derived proteinHuman smooth muscle cellsVascular endothelial cell typesEndothelial cell typesGrowth factorSignificant homologyPosttranslational modificationsSequence dataRapid phosphorylationAcid sequenceBiological activityTyrosine residuesProtein productsCohesive coloniesCommon antigenic determinantsCell typesSpecies-related differencesProteinSerum-derived proteinsHuman hepatocyte growth factor
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