An Invariant Arginine in Common with MHC Class II Allows Extension at the C-Terminal End of Peptides Bound to Chicken MHC Class I
Xiao J, Xiang W, Zhang Y, Peng W, Zhao M, Niu L, Chai Y, Qi J, Wang F, Qi P, Pan C, Han L, Wang M, Kaufman J, Gao G, Liu W. An Invariant Arginine in Common with MHC Class II Allows Extension at the C-Terminal End of Peptides Bound to Chicken MHC Class I. The Journal Of Immunology 2018, 201: 3084-3095. PMID: 30341185, DOI: 10.4049/jimmunol.1800611.Peer-Reviewed Original ResearchConceptsClassical class I moleculesC-terminusNonmammalian vertebratesChicken MHC class IC-terminal endExpressed class I moleculeClass I moleculesPeptide-binding groovePeptides to T lymphocytesJawed vertebratesClass II moleculesArg residuesChicken MHCI moleculesMHC class I allelesRepertoire of peptidesVertebratesPeptide C-terminusII moleculesMammalsClassical class II moleculesClass I allelesPeptideArgI allelesThe newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer
Caldwell A, Coleby R, Tovar C, Stammnitz M, Kwon Y, Owen R, Tringides M, Murchison E, Skjødt K, Thomas G, Kaufman J, Elliott T, Woods G, Siddle H. The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer. ELife 2018, 7: e35314. PMID: 30103855, PMCID: PMC6092122, DOI: 10.7554/elife.35314.Peer-Reviewed Original ResearchConceptsDevil facial tumour 2Devil Facial Tumour 1Contagious cancerExpressed MHC class I allelesLoss of MHCClass I allelesMHC class I allelesNon-polymorphicAllogeneic antigensTumors 2Evolutionary trajectoriesTumor 1Disease 2Tasmanian devilI allelesReduced immunogenicityCancerMHCIn vivoWidespread transmissionHost
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