2022
Transcatheter Aortic Valve Replacement Optimization Strategies: Cusp Overlap, Commissural Alignment, Sizing, and Positioning
Siddique S, Khanal R, Vora A, Gada H. Transcatheter Aortic Valve Replacement Optimization Strategies: Cusp Overlap, Commissural Alignment, Sizing, and Positioning. US Cardiology Review 2022, 16: e10. PMID: 39600846, PMCID: PMC11588177, DOI: 10.15420/usc.2021.24.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementYounger patientsIncreased risk of post-procedural complicationsRisk of post-procedural complicationsCommissural alignmentLow surgical riskProsthesis-patient mismatchAortic valve replacementPost-procedural complicationsCusp-overlap techniqueTranscatheter heart valveSurgical riskValve replacementConduction abnormalitiesParavalvular leakProcedural complicationsCoronary accessCoronary cannulationIncreased riskRisk factorsDelivery techniquesPatientsConduction systemTranscatheterComplications
2020
Permanent conduction system pacing for congenitally corrected transposition of the great arteries: A Pediatric and Congenital Electrophysiology Society (PACES)/International Society for Adult Congenital Heart Disease (ISACHD) Collaborative Study
Moore JP, Gallotti R, Shannon KM, Pilcher T, Vinocur JM, Cano Ó, Kean A, Mondesert B, Nürnberg JH, Schaller RD, Sharma PS, Nishimura T, Tung R. Permanent conduction system pacing for congenitally corrected transposition of the great arteries: A Pediatric and Congenital Electrophysiology Society (PACES)/International Society for Adult Congenital Heart Disease (ISACHD) Collaborative Study. Heart Rhythm 2020, 17: 991-997. PMID: 32243875, DOI: 10.1016/j.hrthm.2020.01.033.Peer-Reviewed Original ResearchConventional cardiac resynchronization therapyConduction system pacingConduction systemGreat arteriesVentricular pacingNew York Heart Association functional classConventional CRTYork Heart Association functional classChronic ventricular pacingJunctional escape rhythmSpontaneous atrioventricular blockCardiac resynchronization therapyCongenital Electrophysiology SocietyPacing-induced cardiomyopathyProximal left bundle branchLeft bundle branchBundle branch pacingUnique anatomic characteristicsCcTGA patientsEscape rhythmHV intervalPrevious surgeryResynchronization therapyAtrioventricular blockPulmonary valve
2019
Mitochondrial thioredoxin-2 maintains HCN4 expression and prevents oxidative stress-mediated sick sinus syndrome
Yang B, Huang Y, Zhang H, Huang Y, Zhou HJ, Young L, Xiao H, Min W. Mitochondrial thioredoxin-2 maintains HCN4 expression and prevents oxidative stress-mediated sick sinus syndrome. Journal Of Molecular And Cellular Cardiology 2019, 138: 291-303. PMID: 31751569, DOI: 10.1016/j.yjmcc.2019.10.009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBradycardiaCardiomyopathy, DilatedEnhancer Elements, GeneticHistone DeacetylasesHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMEF2 Transcription FactorsMice, KnockoutMitochondria, HeartModels, BiologicalOxidative StressPhenotypeProtein BindingReactive Oxygen SpeciesRNA, MessengerSick Sinus SyndromeSinoatrial NodeThioredoxinsConceptsSick sinus syndromeSinus syndromeHistone deacetylase 4Lower heart rateHeart rateHCN4 expressionConduction systemSinoatrial nodeNormal heart rateCardiac conduction systemHistone 3 acetylationMitochondrial oxidative stressSinus bradycardiaCardiac functionLox/SyndromeHeart rhythmMyosin heavy chainHistological analysisMiceDeletion miceOxidative stressWhole heartProtein levelsUnderlying mechanismThoracic Manifestations of Ankylosing Spondylitis, Inflammatory Bowel Disease, and Relapsing Polychondritis
Danve A. Thoracic Manifestations of Ankylosing Spondylitis, Inflammatory Bowel Disease, and Relapsing Polychondritis. Clinics In Chest Medicine 2019, 40: 599-608. PMID: 31376894, DOI: 10.1016/j.ccm.2019.05.006.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseBowel diseaseAnterior chest wall painImmune-mediated inflammatory diseasesChest wall painRestrictive lung diseaseObstructive sleep apneaPulmonary complicationsRelapsing PolychondritisThoracic manifestationsApical fibrosisSleep apneaSpontaneous pneumothoraxLung diseaseAnkylosing SpondylitisLarge airwaysInflammatory conditionsInflammatory diseasesChest wallPolychondritisCardiac valvesVariable involvementConduction systemSpondylitisPatients
2018
Short-Term Effects of Fine Particulate Matter and Ozone on the Cardiac Conduction System in Patients Undergoing Cardiac Catheterization
Zhang S, Breitner S, Cascio W, Devlin R, Neas L, Diaz-Sanchez D, Kraus W, Schwartz J, Hauser E, Peters A, Schneider A. Short-Term Effects of Fine Particulate Matter and Ozone on the Cardiac Conduction System in Patients Undergoing Cardiac Catheterization. ISEE Conference Abstracts 2018, 2018 DOI: 10.1289/isesisee.2018.p01.1190.Peer-Reviewed Original ResearchCardiovascular involvement in systemic rheumatic diseases: An integrated view for the treating physicians
Lee K, Kronbichler A, Eisenhut M, Lee K, Shin J. Cardiovascular involvement in systemic rheumatic diseases: An integrated view for the treating physicians. Autoimmunity Reviews 2018, 17: 201-214. PMID: 29353099, DOI: 10.1016/j.autrev.2017.12.001.Peer-Reviewed Original ResearchConceptsCardiovascular involvementRheumatic diseasesTreating physicianRisk factorsTraditional cardiovascular risk factorsSystemic autoimmune diseaseSystemic rheumatic diseasesCardiovascular risk factorsPotential adverse eventsDisease-specific factorsImmunosuppressive agentsImmunosuppressive drugsPremature atherosclerosisAdverse eventsHeart failureAutoimmune diseasesChronic inflammationCardioprotective efficacyInflammatory activityCardiac vesselsEarly diagnosisOptimal managementIntensive treatmentIncreased MortalityConduction system
2017
Neuromuscular Disease Cardiac Manifestations and Sudden Death Risk
Limipitikul W, Ong CS, Tomaselli GF. Neuromuscular Disease Cardiac Manifestations and Sudden Death Risk. Cardiac Electrophysiology Clinics 2017, 9: 731-747. PMID: 29173414, DOI: 10.1016/j.ccep.2017.07.013.Peer-Reviewed Original ResearchConceptsNeuromuscular diseaseSudden death riskPresence of bradycardiaConduction system diseaseCardiac conduction systemCardiovascular complicationsCardiac manifestationsPreemptive treatmentHeart blockSignificant morbidityVentricular arrhythmiasPermanent pacemakerDeath riskSystem diseasesCardiac arrhythmiasConduction systemDiseasePatientsArrhythmiasRiskBradycardiaMorbidityComplicationsTachyarrhythmiasMortality
2015
Gene therapy to restore electrophysiological function in heart failure
Motloch LJ, Akar FG. Gene therapy to restore electrophysiological function in heart failure. Expert Opinion On Biological Therapy 2015, 15: 803-817. PMID: 25865107, PMCID: PMC5547747, DOI: 10.1517/14712598.2015.1036734.Peer-Reviewed Original ResearchConceptsHeart failureHF patientsMajor public health epidemicPro-arrhythmic activitySafe therapeutic optionSudden cardiac deathCause of morbidityGene therapyPublic health epidemicAbnormal excitabilityCardiac deathTherapeutic optionsTherapeutic effectMyocardial conductionHeart rateLethal arrhythmiasGene therapy approachesElectrophysiological functionUnmet needArrhythmogenic disordersGene-based approachesCalcium cyclingHealth epidemicCardiac gene therapyConduction system
2012
Development of the Heart and Great Vessels
Gruber P, Wessels A, Kubalak S. Development of the Heart and Great Vessels. 2012, 1-26. DOI: 10.1002/9781118320754.ch1.Peer-Reviewed Original Research
1996
The α3 Isoform Protein of the Na+,K+-ATPase Is Associated With the Sites of Cardiac and Neuromuscular Impulse Transmission
Zahler R, Sun W, Ardito T, Zhang Z, Kocsis J, Kashgarian M. The α3 Isoform Protein of the Na+,K+-ATPase Is Associated With the Sites of Cardiac and Neuromuscular Impulse Transmission. Circulation Research 1996, 78: 870-879. PMID: 8620608, DOI: 10.1161/01.res.78.5.870.Peer-Reviewed Original ResearchConceptsNeuromuscular junctionConduction systemImpulse transmissionIsoform-specific antibodiesSkeletal muscle expressesSkeletal musclePresynaptic motor terminalsCardiac conduction systemHeart conduction systemAlpha subunitAxonal processesRat heartCardiac myocytesIsoform mRNAsMuscleClassic morphologyJunctional complexesImmunoreactive proteinPump isoformsAntibodiesIsoform proteinsHeartPump proteinImmunohistochemistryIsoformsNa-K-ATPase alpha-isoform expression in heart and vascular endothelia: cellular and developmental regulation
Zahler R, Sun W, Ardito T, Kashgarian M. Na-K-ATPase alpha-isoform expression in heart and vascular endothelia: cellular and developmental regulation. American Journal Of Physiology 1996, 270: c361-c371. PMID: 8772464, DOI: 10.1152/ajpcell.1996.270.1.c361.Peer-Reviewed Original ResearchConceptsCardiac conduction systemAlpha 2Alpha 1Alpha 3Vascular endotheliumConduction systemHigh ouabain affinityNa-K-ATPase isoformsDevelopmental regulationAlpha 3 expressionImportant species differencesNeonatal rat myocardiumIsoform patternNeonatal ratsPapillary musclesDistinct physiological rolesSmooth muscleImmunohistochemical analysisConduction tissueVentricular myocardiumOuabain affinityRat myocardiumNormal endotheliumRat heartT-tubule system
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