2025
R-Wave Amplitude Changes in Lead aVL Predict Outcomes in Cardiac Resynchronization Therapy: Exploring the Role of Papillary Muscle Dyssynchrony and Mitral Regurgitation
Eötvös C, Avram T, Zehan I, Moldovan M, Sarb A, Lazar R, Coseriu G, Schiop-Tentea P, Blendea E, Mocan-Hognogi D, Chiorescu R, Gusetu G, Pop S, McPherson C, Heist E, Singh J, Blendea D. R-Wave Amplitude Changes in Lead aVL Predict Outcomes in Cardiac Resynchronization Therapy: Exploring the Role of Papillary Muscle Dyssynchrony and Mitral Regurgitation. Heart Rhythm O2 2025 DOI: 10.1016/j.hroo.2025.06.004.Peer-Reviewed Original ResearchCardiac resynchronization therapyPapillary muscle dyssynchronyMitral regurgitationQRS durationResynchronization therapyPapillary musclesMarker of electrical dyssynchronyCardiac resynchronization therapy implantationPredictors of clinical responsePost-CRT changesAnterolateral papillary muscleReducing mitral regurgitationShorter QRS durationMultivariate Cox regressionAnterolateral left ventricular wallLong-term survivalMultivariate logistic regressionR-wave amplitudeClinical responseMR severityPost-CRTElectrical dyssynchronyElectrical resynchronizationMechanical resynchronizationMR improvement
2020
Appropriate and inappropriate shocks in hypertrophic cardiomyopathy patients with subcutaneous implantable cardioverter-defibrillators: An international multicenter study
Nazer B, Dale Z, Carrassa G, Reza N, Ustunkaya T, Papoutsidakis N, Gray A, Howell SJ, Elman MR, Pieragnoli P, Ricciardi G, Jacoby D, Frankel DS, Owens A, Olivotto I, Heitner SB. Appropriate and inappropriate shocks in hypertrophic cardiomyopathy patients with subcutaneous implantable cardioverter-defibrillators: An international multicenter study. Heart Rhythm 2020, 17: 1107-1114. PMID: 32084597, PMCID: PMC8052990, DOI: 10.1016/j.hrthm.2020.02.008.Peer-Reviewed Original ResearchConceptsSecondary prevention patientsAdjusted odds ratioT-wave inversionAppropriate shocksInappropriate shocksHCM patientsR-wave amplitudeHypertrophic cardiomyopathyS-ICDsCardiology/American Heart Association criteriaElectrocardiographic R-wave amplitudeAmerican Heart Association criteriaHCM Risk-SCD scorePrimary prevention patientsS-ICD shocksAbnormal T-wave inversionSustained ventricular arrhythmiasSudden cardiac deathS-ICD implantationHypertrophic cardiomyopathy patientsInternational multicenter studyT-wave oversensingYounger patientsCardiac deathIndependent predictors
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