2016
Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy
Srivastava KD, Siefert A, Fahmy TM, Caplan MJ, Li XM, Sampson HA. Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy. Journal Of Allergy And Clinical Immunology 2016, 138: 536-543.e4. PMID: 27130858, DOI: 10.1016/j.jaci.2016.01.047.Peer-Reviewed Original ResearchConceptsPeanut oral immunotherapyOral peanut challengesPeanut-specific immunotherapyPeanut allergyOral immunotherapyPeanut challengeSymptom scoresRecall responsesMurine modelSplenocyte culturesHistamine levelsPeanut-specific serum IgEC3H/HeJ miceIFN-γ levelsPlasma histamine levelsVehicle control animalsCytokine recall responsesLower symptom scoresBody temperatureCurrent clinical approachesOral sensitizationWeekly gavageIgG2a levelsSublingual immunotherapySerum IgE
2011
High levels of histidine decarboxylase in the striatum of mice and rats
Krusong K, Ercan-Sencicek AG, Xu M, Ohtsu H, Anderson GM, State MW, Pittenger C. High levels of histidine decarboxylase in the striatum of mice and rats. Neuroscience Letters 2011, 495: 110-114. PMID: 21440039, PMCID: PMC3081964, DOI: 10.1016/j.neulet.2011.03.050.Peer-Reviewed Original ResearchConceptsPosterior hypothalamusBasal gangliaHistamine receptorsHistidine decarboxylaseHDC knockout miceStriatum of miceCentral nervous systemHDC proteinTuberomamillary nucleusFunctional innervationHistamine metabolismAxonal projectionsMouse striatumHigh levelsKnockout miceForebrain structuresHistamine levelsNervous systemStriatumNeurotransmitter histamineWestern blotHypothalamusRatsMiceSimilar high levels
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