2024
Neuronal rhythmicity and cortical arousal in a mouse model of absence epilepsy
Khan W, Chopra S, Zheng X, Liu S, Paszkowski P, Valcarce-Aspegren M, Sieu L, Mcgill S, Mccafferty C, Blumenfeld H. Neuronal rhythmicity and cortical arousal in a mouse model of absence epilepsy. Experimental Neurology 2024, 381: 114925. PMID: 39151596, PMCID: PMC12020870, DOI: 10.1016/j.expneurol.2024.114925.Peer-Reviewed Original ResearchExtracellular single unit recordingsSingle unit recordingsMouse modelNeuronal firingAbsence epilepsyFiring patternsRat modelSeizure initiationMouse model of absence epilepsyIn vivo extracellular single unit recordingNeuronal activityUnit recordingsModel of absence epilepsySomatosensory barrel cortexC3H/HeJ mouse modelNeuronal firing rateHuman absence epilepsyDiverse firing patternsNeuronal rhythmicityArousal stateC3H/HeJ miceBarrel cortexStudy of neuronal activityCortical electroencephalographyFiring rate
2021
Network-Related Changes in Neurotransmitters and Seizure Propagation During Rodent Epileptogenesis
Dhaher R, Gruenbaum SE, Sandhu MRS, Ottestad-Hansen S, Tu N, Wang Y, Lee TW, Deshpande K, Spencer DD, Danbolt NC, Zaveri HP, Eid T. Network-Related Changes in Neurotransmitters and Seizure Propagation During Rodent Epileptogenesis. Neurology 2021, 96: e2261-e2271. PMID: 33722994, PMCID: PMC8166437, DOI: 10.1212/wnl.0000000000011846.Peer-Reviewed Original ResearchConceptsSpontaneous seizuresSeizure propagationSeizure focusMesial temporal lobe epilepsyExtracellular brain levelsTemporal lobe epilepsyExtracellular glutamate levelsRelevant rodent modelsGlutamine synthetase inhibitor methionine sulfoximineTransporter subtype 1Contralateral hippocampusLobe epilepsyBrain levelsBrain microdialysisExtracellular GABANeurotransmitter levelsSeizure initiationGlutamate levelsSeizure onsetEpilepsy networkRodent modelsSubtype 1EpileptogenesisHippocampusBrain regions
2018
Altered hippocampal interneuron activity precedes ictal onset
Miri ML, Vinck M, Pant R, Cardin J. Altered hippocampal interneuron activity precedes ictal onset. ELife 2018, 7: e40750. PMID: 30387711, PMCID: PMC6245730, DOI: 10.7554/elife.40750.Peer-Reviewed Original ResearchConceptsSynaptic inhibitionIctal activityEarly ictal phaseHippocampal interneuron activityLocal circuit interactionsSomatostatin-expressing (SST) interneuronsInhibitory interneuron populationsSeizure inductionGABAergic inhibitionSeizure disorderIctal onsetSource of inhibitionSeizure initiationIctal phaseHippocampal circuitsInterneuron activityInterneuron populationsInterneuron classesFiring patternsInterneuronsElectrophysiological approachesPreictal periodInhibitionParvalbuminOnset
2017
Cyclic seizures in critically ill patients: Clinical correlates, DC recordings and outcomes
Pinto LF, Gilmore EJ, Petroff OA, Sivaraju A, Rampal N, Hirsch LJ, Gaspard N. Cyclic seizures in critically ill patients: Clinical correlates, DC recordings and outcomes. Clinical Neurophysiology 2017, 128: 1083-1090. PMID: 28214108, DOI: 10.1016/j.clinph.2017.01.015.Peer-Reviewed Original ResearchConceptsCyclic seizuresProgressive brain injuryStatus epilepticusIll patientsClinical correlatesBrain injuryDC recordingsNon-convulsive status epilepticusEEG baselineNonconvulsive status epilepticusOlder patientsElectrographic seizuresWorse prognosisFocal onsetPoor outcomePrognostic significanceSeizure initiationPatientsInfraslow activitySeizuresCommon formEpilepticusFurther studiesPosterior regionInjury
2015
Using network dynamic fMRI for detection of epileptogenic foci
Nedic S, Stufflebeam S, Rondinoni C, Velasco T, dos Santos A, Leite J, Gargaro A, Mujica-Parodi L, Ide J. Using network dynamic fMRI for detection of epileptogenic foci. BMC Neurology 2015, 15: 262. PMID: 26689596, PMCID: PMC4687299, DOI: 10.1186/s12883-015-0514-y.Peer-Reviewed Original ResearchConceptsEpileptogenic focusHealthy controlsTemporal lobe epilepsy patientsCohort of patientsDuration of epilepsyVoxel functional connectivity analysisIntracranial EEG studiesPrevalent neurological disordersFunctional MRI methodsResting-state fMRIIpsilateral temporal poleFunctional connectivity analysisEpilepsy durationSuccessful surgeryEpileptogenic zoneFocal epilepsySeizure initiationEpilepsy patientsInterictal dischargesPatientsEpileptic regionsTemporal poleNeurological disordersFunctional connectivityImpaired memory
2012
Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events
Žiburkus J, Cressman J, Schiff S. Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events. Journal Of Neurophysiology 2012, 109: 1296-1306. PMID: 23221405, PMCID: PMC3602838, DOI: 10.1152/jn.00232.2012.Peer-Reviewed Original ResearchConceptsSeizure-like eventsO-LM cellsPyramidal cellsInhibitory conductanceOriens-lacunosum moleculare (O-LM) interneuronsNeuronal network hyperexcitabilityExcitability of interneuronsCA1 pyramidal cellsInhibitory synaptic conductancesNetwork hyperexcitabilityRecurrent seizuresMoleculare interneuronsSeizure initiationNeural network activityRat hippocampusExtracellular magnesiumSynaptic barragesFiring patternsSeizuresExcitatoryCellular subtypesSynaptic conductancesInterneuronsNetwork activityCell types
2010
Dynamic Time Course of Typical Childhood Absence Seizures: EEG, Behavior, and Functional Magnetic Resonance Imaging
Bai X, Vestal M, Berman R, Negishi M, Spann M, Vega C, Desalvo M, Novotny EJ, Constable RT, Blumenfeld H. Dynamic Time Course of Typical Childhood Absence Seizures: EEG, Behavior, and Functional Magnetic Resonance Imaging. Journal Of Neuroscience 2010, 30: 5884-5893. PMID: 20427649, PMCID: PMC2946206, DOI: 10.1523/jneurosci.5101-09.2010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainBrain MappingCerebrovascular CirculationChildElectroencephalographyEpilepsy, AbsenceFemaleHumansLinear ModelsMagnetic Resonance ImagingMaleModels, NeurologicalMotor ActivityNeuropsychological TestsPsychomotor PerformanceSeizuresSignal Processing, Computer-AssistedTime FactorsConceptsTypical childhood absence seizuresChildhood absence seizuresAbsence seizuresFMRI decreasesSeizure onsetHz spike-wave dischargesMagnetic resonance imaging changesFunctional magnetic resonance imaging (fMRI) changesTime courseHz generalized spikeSpike-wave dischargesFunctional magnetic resonance imagingMagnetic resonance imagingRepetitive tapping taskLateral parietal cortexLateral frontal cortexImpaired consciousnessPediatric patientsImaging changesEEG time-frequency analysisSeizure endMean durationSeizure initiationGeneralized spikeFMRI changes
2007
Cyclic electrographic seizures in critically ill patients
Friedman DE, Schevon C, Emerson RG, Hirsch LJ. Cyclic electrographic seizures in critically ill patients. Epilepsia 2007, 49: 281-287. PMID: 17900293, DOI: 10.1111/j.1528-1167.2007.01327.x.Peer-Reviewed Original ResearchConceptsCyclic seizuresIll patientsPattern of seizuresStandard EEG recordingsNonconvulsive seizuresStatus epilepticusElectrographic seizuresSeizure activityUnderlying pathophysiologyElectroencephalographic monitoringSeizure initiationEEG frequency spectrumPatientsSeizuresContinuous EEGEEG powerPathophysiologyEEG recordingsCsAEpilepticusCessation
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