2019
GABAergic Restriction of Network Dynamics Regulates Interneuron Survival in the Developing Cortex
Duan Z, Che A, Chu P, Modol L, Bollmann Y, Babij R, Fetcho R, Otsuka T, Fuccillo M, Liston C, Pisapia D, Cossart R, De Marco García N. GABAergic Restriction of Network Dynamics Regulates Interneuron Survival in the Developing Cortex. Neuron 2019, 105: 75-92.e5. PMID: 31780329, PMCID: PMC6982374, DOI: 10.1016/j.neuron.2019.10.008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCell SurvivalExcitatory Postsynaptic PotentialsFemaleGABAergic Neuronsgamma-Aminobutyric AcidInhibitory Postsynaptic PotentialsInterneuronsMaleMedian EminenceMembrane PotentialsMiceMice, TransgenicNeural PathwaysNeurogenesisParvalbuminsPyramidal CellsSomatosensory CortexSomatostatinSynaptic PotentialsConceptsPyramidal cellsGanglionic eminenceReduction of GABA releaseIncreased network synchronyAssembly of neuronal circuitsEffects of GABAMedial ganglionic eminenceCaudal ganglionic eminenceSpontaneous activity patternsGABA releaseInterneuron survivalPostnatal daySomatostatin interneuronsNeonatal developmentMouse pupsSynaptic inputsCalcium imagingInterneuronsDeveloping cortexIncreased SurvivalNeuronal circuitsSomatosensory cortexAberrant patternsNetwork synchronySensory cortexBtbd3 expression regulates compulsive-like and exploratory behaviors in mice
Thompson SL, Welch AC, Ho EV, Bessa JM, Portugal-Nunes C, Morais M, Young JW, Knowles JA, Dulawa SC. Btbd3 expression regulates compulsive-like and exploratory behaviors in mice. Translational Psychiatry 2019, 9: 222. PMID: 31501410, PMCID: PMC6733800, DOI: 10.1038/s41398-019-0558-7.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderKnockout miceCompulsive-like behaviorLimbic cortico-striatoExploratory behaviorThalamo-cortical circuitsMarble-burying testPrimary sensory cortexNeural circuit formationDendritic morphologyImpaired goal-directed behaviorAnterior cingulate cortexGoal-directed behaviorChronic treatmentSpine densityCortico-striatoMediodorsal thalamusDendritic pruningSensory cortexNeonatal developmentAnterior cingulateCingulate cortexCircuit formationPotential risk genesMice
2018
Layer I Interneurons Sharpen Sensory Maps during Neonatal Development
Che A, Babij R, Iannone A, Fetcho R, Ferrer M, Liston C, Fishell G, De Marco García N. Layer I Interneurons Sharpen Sensory Maps during Neonatal Development. Neuron 2018, 99: 98-116.e7. PMID: 29937280, PMCID: PMC6152945, DOI: 10.1016/j.neuron.2018.06.002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCalciumCell Adhesion Molecules, NeuronalCerebral CortexExtracellular Matrix ProteinsGene Knockdown TechniquesInterneuronsMiceNerve Tissue ProteinsNeural PathwaysOptogeneticsPatch-Clamp TechniquesPhysical StimulationPyramidal CellsReceptors, N-Methyl-D-AspartateReceptors, Serotonin, 5-HT3Reelin ProteinSensory DeprivationSerine EndopeptidasesSomatosensory CortexTouchVibrissaeConceptsNMDA receptorsWhisker-dependent behaviorsSpontaneous calcium transientsDiverse neuronal typesPostnatal day 6Barrel map formationLayer IIntrinsic neuronal activityCalcium transientsSerotonin receptorsBarrel cortexWhisker stimulationInterneuron typesLongitudinal calcium imagingMouse pupsNeonatal developmentSensory mapsWhisker responsesCalcium imagingNeonatal mammalsNeuronal activityInterneuronsNeuron typesThalamic inputDay 6
2017
Pumpless Extracorporeal Support of the Preterm Infant: Bridging Fetal and Postnatal Physiology
Partridge E, Davey M, Hornick M, Flake A. Pumpless Extracorporeal Support of the Preterm Infant: Bridging Fetal and Postnatal Physiology. NeoReviews 2017, 18: e277-e282. DOI: 10.1542/neo.18-5-e277.Peer-Reviewed Original ResearchPreterm infantsExtracorporeal supportExtremely preterm infantsExtracorporeal membrane oxygenation (ECMO) technologyStable hemodynamicsPreterm birthClinical outcomesUmbilical circulationChildhood morbidityFetal perfusionNeonatal careNeonatal mortalityFetal lambsFetal survivalIntrauterine environmentClinical challengeNeonatal developmentFetal heartInfantsUnsolved clinical challengeExtracorporeal systemPhysiologic homeostasisMajor causePhysiologic systemsOrgan maturation
2016
Zika virus infection of Hofbauer cells
Simoni MK, Jurado KA, Abrahams VM, Fikrig E, Guller S. Zika virus infection of Hofbauer cells. American Journal Of Reproductive Immunology 2016, 77 PMID: 27966815, PMCID: PMC5299062, DOI: 10.1111/aji.12613.Peer-Reviewed Original ResearchConceptsCongenital Zika syndromeHofbauer cellsZika virusZIKV infectionDevelopment of CZSDengue virusSpread of ZIKVVertical transmissionFetal placental macrophagesPlacental Hofbauer cellsZika virus infectionAntenatal infectionNeonatal outcomesPlacental responsesZika syndromeVirus infectionCurrent evidenceCongenital abnormalitiesRecent studiesNeonatal developmentFetal capillariesRelated flavivirusesInfectionSpecific molecular mechanismsCertain viruses
2012
Lactation and Neonatal Nutrition: Defining and Refining the Critical Questions
Neville MC, Anderson SM, McManaman JL, Badger TM, Bunik M, Contractor N, Crume T, Dabelea D, Donovan SM, Forman N, Frank DN, Friedman JE, German JB, Goldman A, Hadsell D, Hambidge M, Hinde K, Horseman ND, Hovey RC, Janoff E, Krebs NF, Lebrilla CB, Lemay DG, MacLean PS, Meier P, Morrow AL, Neu J, Nommsen-Rivers LA, Raiten DJ, Rijnkels M, Seewaldt V, Shur BD, VanHouten J, Williamson P. Lactation and Neonatal Nutrition: Defining and Refining the Critical Questions. Journal Of Mammary Gland Biology And Neoplasia 2012, 17: 167-188. PMID: 22752723, PMCID: PMC3428522, DOI: 10.1007/s10911-012-9261-5.Peer-Reviewed Original ResearchConceptsHuman milk compositionMammary gland developmentGestational diabetesObese mothersPreterm infantsUndernourished mothersMaternal nutritionNeonatal nutritionHuman milkInfant nutritionNeonatal developmentSpecific nutritional challengesSpecific training recommendationsMammary developmentUnanswered questionsHuman lactationMetabolic statusInfantsTherapeutic drugsGland developmentNutritional challengesImportant unanswered questionsMilk componentsBehavioral phenotypesLactation
2009
Hypoxic Injury during Neonatal Development in Murine Brain: Correlation between In Vivo DTI Findings and Behavioral Assessment
Chahboune H, Ment LR, Stewart WB, Rothman DL, Vaccarino FM, Hyder F, Schwartz ML. Hypoxic Injury during Neonatal Development in Murine Brain: Correlation between In Vivo DTI Findings and Behavioral Assessment. Cerebral Cortex 2009, 19: 2891-2901. PMID: 19380380, PMCID: PMC2774398, DOI: 10.1093/cercor/bhp068.Peer-Reviewed Original ResearchConceptsChronic sublethal hypoxiaLow birth weight preterm infantsBirth weight preterm infantsHypoxia-induced modificationNeonatal rodent modelPreterm birth resultsWeight preterm infantsSignificant neurodevelopmental disabilitiesOpen field taskGreater locomotor activityPreterm infantsPreterm birthNeurodevelopmental consequencesBirth resultsHypoxic injurySomatosensory cortexCaudate putamenCallosal connectivityCorpus callosumBehavioral deficitsNeurodevelopmental disabilitiesRodent modelsNeonatal developmentDTI findingsSublethal hypoxia
2006
Origins of peripheral B cells in IL-7 receptor-deficient mice
Hesslein DG, Yang SY, Schatz DG. Origins of peripheral B cells in IL-7 receptor-deficient mice. Molecular Immunology 2006, 43: 326-334. PMID: 16310046, DOI: 10.1016/j.molimm.2005.02.010.Peer-Reviewed Original ResearchConceptsIL-7Ralpha-deficient miceB cell populationsB cellsBone marrowSplenic B cellsIL-7RalphaCell percentageIL-7 receptor-deficient miceCell populationsReceptor-deficient micePeripheral B cellsSplenic B cell populationSpleens of adultBone marrow-derived B cellsReceptor alpha geneEarly lymphoid differentiationAdult bone marrowSplenic populationsPeripheral BNeonatal developmentB cell developmentFollicular cellsMarrowMiceFetal liver
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