2023
Masterminding Hippocampal Circuits by Transplanting Human GABAergic Interneurons to Treat Temporal Lobe Epilepsy
Gupta J, Naegele J. Masterminding Hippocampal Circuits by Transplanting Human GABAergic Interneurons to Treat Temporal Lobe Epilepsy. Epilepsy Currents 2023, 23: 268-270. PMID: 37662454, PMCID: PMC10470101, DOI: 10.1177/15357597231175010.Peer-Reviewed Original ResearchModel of epilepsyTemporal lobe epilepsyLong-term efficacySpecific synaptic connectionsAbort seizuresGraft functionMishra AHost neuronsSeizure controlLobe epilepsyIntractable epilepsySeizure activityGABAergic interneuronsMonosynaptic tracingCortical interneuronsHippocampal circuitsOptogenetic activationProlonged efficacyHost inhibitionSynaptic connectionsEpilepsySeizuresEfficacyInterneuronsClinical translation
2022
A transcriptomic axis predicts state modulation of cortical interneurons
Bugeon S, Duffield J, Dipoppa M, Ritoux A, Prankerd I, Nicoloutsopoulos D, Orme D, Shinn M, Peng H, Forrest H, Viduolyte A, Reddy C, Isogai Y, Carandini M, Harris K. A transcriptomic axis predicts state modulation of cortical interneurons. Nature 2022, 607: 330-338. PMID: 35794483, PMCID: PMC9279161, DOI: 10.1038/s41586-022-04915-7.Peer-Reviewed Original ResearchConceptsOscillatory brain statesInhibitory subtypesBrain statesPrimary visual cortexInhibitory neuronsIn vivo two-photon calcium imagingTwo-photon calcium imagingInhibitory cholinergic receptorsCortical inhibitory neuronsEx vivo slicesV1 subtypeVisual cortexCortical interneuronsDiverse patterns of activityLow input resistanceCholinergic receptorsState modulationInput resistanceCalcium imagingSubtypesAxonal projectionsCortical processingStateBrainNeurons
2020
Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines
Ali F, Gerhard DM, Sweasy K, Pothula S, Pittenger C, Duman RS, Kwan AC. Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines. Nature Communications 2020, 11: 72. PMID: 31911591, PMCID: PMC6946708, DOI: 10.1038/s41467-019-13809-8.Peer-Reviewed Original ResearchConceptsDendritic spinesN-methyl-D-aspartate receptor antagonistPrefrontal cortexPrefrontal dendritic spinesApical dendritic spinesSomatostatin-expressing (SST) interneuronsCortico-cortical connectivityElevated calcium levelsMedial prefrontal cortexKetamine actsAntidepressant effectsGABAergic neuronsSST interneuronsKetamine actionPyramidal neuronsNMDAR antagonismReceptor antagonistSubanesthetic ketamineSubanesthetic doseDendritic inhibitionAwake miceCortical interneuronsSynaptic inputsCalcium levelsCalcium transients
2019
Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits
Favuzzi E, Deogracias R, Marques-Smith A, Maeso P, Jezequel J, Exposito-Alonso D, Balia M, Kroon T, Hinojosa A, F Maraver E, Rico B. Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits. Science 2019, 363: 413-417. PMID: 30679375, DOI: 10.1126/science.aau8977.Peer-Reviewed Original ResearchConceptsCortical inhibitory circuitsInhibitory circuitsClasses of GABAergic interneuronsInvestigate transcriptional dynamicsClasses of interneuronsConnectivity patternsAxon initial segmentGABAergic interneuronsMammalian cerebral cortexTranscriptional dynamicsCortical interneuronsPyramidal cellsSynapse specificityPostnatal developmentInterneuron diversityInterneuronsCerebral cortexMolecular mechanismsConnectivity motifsSynaptic moleculesBrain functionMolecular programsNeuronal connectivityInformation processingFunctional networks
2018
Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons
Wamsley B, Jaglin X, Favuzzi E, Quattrocolo G, Nigro M, Yusuf N, Khodadadi-Jamayran A, Rudy B, Fishell G. Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons. Neuron 2018, 100: 846-859.e7. PMID: 30318414, PMCID: PMC6541232, DOI: 10.1016/j.neuron.2018.09.026.Peer-Reviewed Original Research
2014
Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin
Rossier J, Bernard A, Cabungcal J, Perrenoud Q, Savoye A, Gallopin T, Hawrylycz M, Cuénod M, Do K, Urban A, Lein E. Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin. Molecular Psychiatry 2014, 20: 154-161. PMID: 25510509, PMCID: PMC4356748, DOI: 10.1038/mp.2014.162.Peer-Reviewed Original ResearchConceptsPerineuronal netsSomatosensory cerebral cortexWisteria floribunda agglutininCerebral cortexParvalbumin interneuronsCortical interneuronsInterneuron markersAmyloid β-peptidePatch clampAllen Mouse Brain AtlasInterneuronsPattern of expressionSpecific markersMouse Brain AtlasPvalbAllen AtlasADAMTS15NeprilysinBrain atlasMultiplex PCRΒ-peptideMarkersFgfr1 Inactivation in the Mouse Telencephalon Results in Impaired Maturation of Interneurons Expressing Parvalbumin
Smith KM, Maragnoli ME, Phull PM, Tran KM, Choubey L, Vaccarino FM. Fgfr1 Inactivation in the Mouse Telencephalon Results in Impaired Maturation of Interneurons Expressing Parvalbumin. PLOS ONE 2014, 9: e103696. PMID: 25116473, PMCID: PMC4130531, DOI: 10.1371/journal.pone.0103696.Peer-Reviewed Original ResearchConceptsGanglionic eminenceSoma sizeCortical interneuronsAstrocytes of miceCortex of adultCortical GABAergic neuronsParvalbumin-positive cortical interneuronsRadial glial cellsSmaller soma sizeMedial ganglionic eminenceFibroblast growth factorDeficient astrocytesLocomotor hyperactivityGABAergic cellsGABAergic neuronsInterneuron maturationGlial cellsCortical astrocytesPostnatal periodAdult CNSPostnatal brainInterneuron markersInterneuronsImmunopositive interneuronsAstrocytes
2013
Hypoxia-Induced Developmental Delays of Inhibitory Interneurons Are Reversed by Environmental Enrichment in the Postnatal Mouse Forebrain
Komitova M, Xenos D, Salmaso N, Tran KM, Brand T, Schwartz ML, Ment L, Vaccarino FM. Hypoxia-Induced Developmental Delays of Inhibitory Interneurons Are Reversed by Environmental Enrichment in the Postnatal Mouse Forebrain. Journal Of Neuroscience 2013, 33: 13375-13387. PMID: 23946395, PMCID: PMC3742925, DOI: 10.1523/jneurosci.5286-12.2013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Adhesion Molecules, NeuronalCerebral CortexChromatography, High Pressure LiquidDisease Models, AnimalExtracellular Matrix ProteinsGene Knock-In TechniquesHousing, AnimalHypoxiaImmunohistochemistryInterneuronsMiceMice, Inbred C57BLMice, TransgenicNerve Tissue ProteinsParvalbuminsProsencephalonReelin ProteinSerine EndopeptidasesSomatostatinConceptsCortical interneuronsNormoxic controlsMarker expressionPostnatal cortical developmentVasoactive intestinal peptidePostnatal day 3Central nervous systemTotal GABA contentImpact of hypoxicPostnatal mouse forebrainEnvironmental enrichmentIntestinal peptideGABAergic interneuronsFrontal neocortexInhibitory interneuronsCortical developmentMouse modelReelin expressionInterneuron numbersNervous systemDay 3Cognitive impairmentInterneuronsHousing miceRLN expression
2009
Selective Depletion of Molecularly Defined Cortical Interneurons in Human Holoprosencephaly with Severe Striatal Hypoplasia
Fertuzinhos S, Krsnik Ž, Kawasawa YI, Rašin M, Kwan KY, Chen JG, Judaš M, Hayashi M, Šestan N. Selective Depletion of Molecularly Defined Cortical Interneurons in Human Holoprosencephaly with Severe Striatal Hypoplasia. Cerebral Cortex 2009, 19: 2196-2207. PMID: 19234067, PMCID: PMC2722430, DOI: 10.1093/cercor/bhp009.Peer-Reviewed Original ResearchConceptsCortical interneuronsProjection neuronsInterneuron subtypesDorsal forebrainNitric oxide synthase 1Ventral forebrainCortical interneuron diversityGlutamatergic projection neuronsHuman holoprosencephalyInhibitory GABAergic interneuronsCortex of controlCortical interneuron subtypesEarly fetal periodClinical manifestationsInfant casesNeuropeptide YGABAergic interneuronsNeuronal pathogenesisCalretinin expressionInterneuronsFetal periodDifferent subtypesSelective depletionInterneuron diversityForebrain
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