2022
Gabrb3 is required for the functional integration of pyramidal neuron subtypes in the somatosensory cortex
Babij R, Ferrer C, Donatelle A, Wacks S, Buch A, Niemeyer J, Ma H, Duan Z, Fetcho R, Che A, Otsuka T, Schwartz T, Huang B, Liston C, De Marco García N. Gabrb3 is required for the functional integration of pyramidal neuron subtypes in the somatosensory cortex. Neuron 2022, 111: 256-274.e10. PMID: 36446382, PMCID: PMC9852093, DOI: 10.1016/j.neuron.2022.10.037.Peer-Reviewed Original ResearchConceptsAssociated with autism spectrum disorderNeuronal subtypesAngelman syndromePyramidal neuron subtypesAssociated with neurodevelopmental disordersGABAergic synapsesWidefield calcium imagingPyramidal neuronsAutism spectrum disorderNeonatal stageTwo-photonCalcium imagingResponse to tactile stimulationGABRB3Developmental decreaseSomatosensory cortexAtypical connectivityNetwork synchronyFunctional connectivitySpectrum disorderInterhemispheric circuitInhibitory functionSensory processingNeurodevelopmental disordersASD subjects
2020
Responsive Neurostimulation
Gummadavelli A, Quraishi I, Gerrard J. Responsive Neurostimulation. 2020, 145-173. DOI: 10.1007/978-3-030-34906-6_12.ChaptersResponsive neurostimulationRefractory epilepsyIntracranial EEG activityUse of neurostimulationSurgical implantation techniqueChronic electrophysiological recordingsSeizure progressionTherapeutic approachesNeurological disordersElectrophysiological recordingsNeurostimulationDisease statesEEG activityNetwork synchronyEpilepsyImplantation techniquePathology
2019
GABAergic Restriction of Network Dynamics Regulates Interneuron Survival in the Developing Cortex
Duan Z, Che A, Chu P, Modol L, Bollmann Y, Babij R, Fetcho R, Otsuka T, Fuccillo M, Liston C, Pisapia D, Cossart R, De Marco García N. GABAergic Restriction of Network Dynamics Regulates Interneuron Survival in the Developing Cortex. Neuron 2019, 105: 75-92.e5. PMID: 31780329, PMCID: PMC6982374, DOI: 10.1016/j.neuron.2019.10.008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCell SurvivalExcitatory Postsynaptic PotentialsFemaleGABAergic Neuronsgamma-Aminobutyric AcidInhibitory Postsynaptic PotentialsInterneuronsMaleMedian EminenceMembrane PotentialsMiceMice, TransgenicNeural PathwaysNeurogenesisParvalbuminsPyramidal CellsSomatosensory CortexSomatostatinSynaptic PotentialsConceptsPyramidal cellsGanglionic eminenceReduction of GABA releaseIncreased network synchronyAssembly of neuronal circuitsEffects of GABAMedial ganglionic eminenceCaudal ganglionic eminenceSpontaneous activity patternsGABA releaseInterneuron survivalPostnatal daySomatostatin interneuronsNeonatal developmentMouse pupsSynaptic inputsCalcium imagingInterneuronsDeveloping cortexIncreased SurvivalNeuronal circuitsSomatosensory cortexAberrant patternsNetwork synchronySensory cortex
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