2023
CD4dimCD8bright T cells are inversely associated with neuro-inflammatory markers among people with HIV
Albalawi Y, Shull T, Virdi A, Subra C, Mitchell J, Slike B, Jian N, Krebs S, Sacdalan C, Ratnaratorn N, Hsu D, Phanuphak N, Spudich S, Trautmann L, Al-Harthi L. CD4dimCD8bright T cells are inversely associated with neuro-inflammatory markers among people with HIV. AIDS 2023, 38: 1-7. PMID: 37792358, PMCID: PMC10715695, DOI: 10.1097/qad.0000000000003743.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyT cellsWeeks 0CD4-CD8Cerebrospinal fluidImmune activationSoluble markersSuppressive combination antiretroviral therapyPeripheral blood T cellsNeuro-inflammatory markersSubset of CD8Anti-inflammatory propertiesBlood T cellsConfidence intervalsPlasma of peopleT-cell typeCART initiationCSF neopterinPlasma RANTESAntiretroviral therapyWeek 24IP-10IL-6Lumbar punctureIL-8
2021
ICBP90 Regulates MIF Expression, Glucocorticoid Sensitivity, and Apoptosis at the MIF Immune Susceptibility Locus
Yao J, Leng L, Fu W, Li J, Bronner C, Bucala R. ICBP90 Regulates MIF Expression, Glucocorticoid Sensitivity, and Apoptosis at the MIF Immune Susceptibility Locus. Arthritis & Rheumatology 2021, 73: 1931-1942. PMID: 33844457, DOI: 10.1002/art.41753.Peer-Reviewed Original ResearchMeSH KeywordsAllelesApoptosisCCAAT-Enhancer-Binding ProteinsCell LineFibroblastsGene Expression RegulationGenetic LociGenetic Predisposition to DiseaseGenotypeGlucocorticoidsHumansIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsPromoter Regions, GeneticReceptors, GlucocorticoidUbiquitin-Protein LigasesConceptsMacrophage migration inhibitory factorAutoimmune disease severityMIF -794 CATTRheumatoid synovial fibroblastsMIF expressionGlucocorticoid receptorGlucocorticoid sensitivitySynovial fibroblastsT cellsDisease severityPeripheral blood T cellsBlood T cellsMigration inhibitory factorGlucocorticoid-treated cellsAP-1Glucocorticoid immunosuppressionMIF promoterMIF genotypeMIF polymorphismsFactor antibodyInflammatory responseT lymphocytesActivator protein-1Glucocorticoid responsivenessInhibitory factorTargeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation
Healey D, Cephus J, Barone S, Chowdhury N, Dahunsi D, Madden M, Ye X, Yu X, Olszewski K, Young K, Gerriets V, Siska P, Dworski R, Hemler J, Locasale J, Poyurovsky M, Peebles R, Irish J, Newcomb D, Rathmell J. Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation. The Journal Of Immunology 2021, 206: 1127-1139. PMID: 33558372, PMCID: PMC7946768, DOI: 10.4049/jimmunol.2001029.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlternariaAnimalsAsthmaBiomarkersBlood GlucoseBronchoalveolar Lavage FluidCase-Control StudiesCells, CulturedDexamethasoneDisease Models, AnimalDrug SynergismFemaleGlucose Transporter Type 1GlutaminaseGlutamineHealthy VolunteersHumansImmunosuppressive AgentsLungMaleMiceMiddle AgedPrimary Cell CulturePyroglyphidaeTh17 CellsTh2 CellsYoung AdultConceptsAirway inflammationHouse dust miteT cellsAsthmatic patientsCytokine productionDust miteIL-17-producing T cellsTh17 CD4 T cellsIL-17-producing cellsT cell cytokine productionPeripheral blood T cellsAllergic airway inflammationT effector cellsCD4 T cellsBronchoalveolar lavage fluidCell cytokine productionInflammatory cytokine productionBlood T cellsLungs of miceGlutamine metabolismAbundant IL-4Glucose transporter 1Airway hyperresponsivenessSteroid therapyEffector cells
2020
Breast cancer induces systemic immune changes on cytokine signaling in peripheral blood monocytes and lymphocytes
Wang L, Simons D, Lu X, Tu T, Avalos C, Chang A, Dirbas F, Yim J, Waisman J, Lee P. Breast cancer induces systemic immune changes on cytokine signaling in peripheral blood monocytes and lymphocytes. EBioMedicine 2020, 52: 102631. PMID: 31981982, PMCID: PMC6992943, DOI: 10.1016/j.ebiom.2020.102631.Peer-Reviewed Original ResearchConceptsSystemic immune changesPeripheral blood monocytesBreast Cancer Research FoundationBreast Cancer Research ProgramBC patientsImmune changesBlood monocytesPeripheral bloodImmune cellsNon-metastatic BC patientsPeripheral blood immune cellsPeripheral blood T cellsCancer patients' peripheral bloodBlood immune cellsBreast cancer patientsOverall immune statusBlood T cellsPatients' peripheral bloodTumor-infiltrating macrophagesDefense Breast Cancer Research ProgramCancer Research ProgramCancer Research FoundationConcurrent cytokineLocalized diseaseImmune status
2017
IL6 Signaling in Peripheral Blood T Cells Predicts Clinical Outcome in Breast Cancer
Wang L, Miyahira A, Simons D, Lu X, Chang A, Wang C, Suni M, Maino V, Dirbas F, Yim J, Waisman J, Lee P. IL6 Signaling in Peripheral Blood T Cells Predicts Clinical Outcome in Breast Cancer. Cancer Research 2017, 77: 1119-1126. PMID: 27879265, PMCID: PMC5334262, DOI: 10.1158/0008-5472.can-16-1373.Peer-Reviewed Original ResearchConceptsPeripheral blood T cellsBreast cancer patientsBlood T cellsCancer patientsT cellsIL6 levelsWorse relapse-free survivalPlasma IL6 levelsCancer cellsRelapse-free survivalSerum IL6 levelsAnti-inflammatory propertiesHost immune responseInvolved downregulationClinical outcomesPredictive biomarkersImmune responsePleiotropic cytokinePatientsIL6Cancer ResCancer progressionSurvivalDiagnosisCells
2001
Uncoupling p70s6 Kinase Activation and Proliferation: Rapamycin-Resistant Proliferation of Human CD8+ T Lymphocytes
Slavik J, Lim D, Burakoff S, Hafler D. Uncoupling p70s6 Kinase Activation and Proliferation: Rapamycin-Resistant Proliferation of Human CD8+ T Lymphocytes. The Journal Of Immunology 2001, 166: 3201-3209. PMID: 11207273, DOI: 10.4049/jimmunol.166.5.3201.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalCD2 AntigensCD28 AntigensCD3 ComplexCD8 AntigensCD8-Positive T-LymphocytesCell Line, TransformedClone CellsDose-Response Relationship, DrugDose-Response Relationship, ImmunologicDrug ResistanceEnzyme ActivationEpitopes, T-LymphocyteHLA-A AntigensHumansImmunosuppressive AgentsInterleukin-2Lymphocyte ActivationMajor Histocompatibility ComplexModels, ImmunologicalRibosomal Protein S6 KinasesSirolimusT-Lymphocyte SubsetsConceptsT cell clonesT cellsEffect of rapamycinHuman T cell responsesPeripheral blood T cellsCell clonesHeterogeneous proliferative responsesT cell responsesBlood T cellsT cell proliferationSpecific costimulatory signalsGraft infiltrationResistant proliferationInhibition of AgGraft rejectionHuman CD8IL-2RT lymphocytesProliferative responseCostimulatory signalsCell responsesPresence of rapamycinCell proliferationRapamycinProliferation
2000
Development and Therapeutic Effect of Adoptively Transferred T Cells Primed by Tumor Lysate-Pulsed Autologous Dendritic Cells in a Patient with Metastatic Endometrial Cancer
Santin AD, Hermonat PL, Ravaggi A, Bellone S, Cowan C, Coke C, Pecorelli S, Cannon MJ, Parham GP. Development and Therapeutic Effect of Adoptively Transferred T Cells Primed by Tumor Lysate-Pulsed Autologous Dendritic Cells in a Patient with Metastatic Endometrial Cancer. Gynecologic And Obstetric Investigation 2000, 49: 194-203. PMID: 10729762, DOI: 10.1159/000010246.Peer-Reviewed Original ResearchMeSH KeywordsAgedCD56 AntigenCD8-Positive T-LymphocytesCombined Modality TherapyDendritic CellsEndometrial NeoplasmsFemaleFlow CytometryHepatic ArteryHistocompatibility Antigens Class IHumansImmunophenotypingImmunotherapy, AdoptiveL-Lactate DehydrogenaseLiver NeoplasmsT-LymphocytesTomography, X-Ray ComputedUric AcidConceptsAutologous dendritic cellsDendritic cellsT cellsLiver metastasesEndometrial cancerAutologous Epstein-Barr virus-transformed lymphoblastoid cellsNK-sensitive K562 cellsSerial gamma camera imagingType 1 cytokine biasTumor-specific T cellsTwo-color flow cytometric analysisPeripheral blood T cellsLarge liver metastasesMetastatic endometrial cancerAutologous tumor cellsTumor-specific CD8T cell responsesEpstein-Barr virus-transformed lymphoblastoid cellsSerum uric acidIntracellular IFN-gammaBlood T cellsLactate dehydrogenaseT-cell immunotherapyLarge tumor massSerial time pointsDevelopment, characterization and distribution of adoptively transferred peripheral blood lymphocytes primed by human papillomavirus 18 E7--pulsed autologous dendritic cells in a patient with metastatic adenocarcinoma of the uterine cervix.
Santin AD, Hermonat PL, Ravaggi A, Bellone S, Cowan C, Korourian S, Pecorelli S, Cannon MJ, Parham GP. Development, characterization and distribution of adoptively transferred peripheral blood lymphocytes primed by human papillomavirus 18 E7--pulsed autologous dendritic cells in a patient with metastatic adenocarcinoma of the uterine cervix. European Journal Of Gynaecological Oncology 2000, 21: 17-23. PMID: 10726612.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsAutologous dendritic cellsDendritic cellsT cellsMetastatic diseaseUterine cervixAutologous Epstein-Barr virus-transformed lymphoblastoid cellsNK-sensitive K562 cellsSerial gamma camera imagingTumor-specific T cellsTwo-color flow cytometric analysisPeripheral blood T cellsTumor cellsIntracellular cytokine productionAutologous tumor cellsExtensive metastatic diseaseInvasive cervical cancerTumor-specific CTLsIntracellular cytokine expressionEpstein-Barr virus-transformed lymphoblastoid cellsBlood mononuclear cellsTreatment of patientsBlood T cellsCytotoxic T cellsPeripheral blood lymphocytes
1998
Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation.
Scholz C, Patton K, Anderson D, Freeman G, Hafler D. Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation. The Journal Of Immunology 1998, 160: 1532-8. PMID: 9570577, DOI: 10.4049/jimmunol.160.3.1532.Peer-Reviewed Original ResearchMeSH KeywordsAbataceptAntigens, CDAntigens, DifferentiationAutoantigensB7-1 AntigenB7-2 AntigenClone CellsCTLA-4 AntigenEpitopes, T-LymphocyteHumansImmunoconjugatesImmunoglobulin Fc FragmentsImmunosuppressive AgentsInterleukin-4Lymphocyte ActivationMembrane GlycoproteinsMultiple SclerosisMyelin Basic ProteinRecombinant Fusion ProteinsTetanus ToxoidThymidineT-Lymphocyte SubsetsConceptsCD4 T cellsMultiple sclerosisT cellsB7-1Myelin basic proteinPathogenesis of MSMyelin-reactive T cellsPeripheral blood T cellsB7-2 engagementAutoreactive T cellsBlood T cellsAbsence of costimulationCentral nervous systemAntigen-specific signalT cell activationMS patientsB7 costimulationInflammatory diseasesTetanus toxoidB7-2Normal controlsNormal subjectsCostimulatory signalsNervous systemCell activation
1996
Downregulation of IL‐10 secretion and enhanced antigen‐presenting abilities following HTLV‐I infection of T cells
Scholz C, Hafler DA, Höllsberg P. Downregulation of IL‐10 secretion and enhanced antigen‐presenting abilities following HTLV‐I infection of T cells. Journal Of Neuroscience Research 1996, 45: 786-794. PMID: 8892090, DOI: 10.1002/(sici)1097-4547(19960915)45:6<786::aid-jnr15>3.0.co;2-u.Peer-Reviewed Original ResearchConceptsT cell clonesAntigen-presenting abilityHTLV-I infectionT cellsUninfected T cellsIL-10Immunosuppressive cytokine IL-10Human T-cell lymphotropic virus type ICD8 T cell proliferationMajor histocompatibility complex class IIPeripheral blood T cellsSpecific T cell clonesHistocompatibility complex class IILymphotropic virus type IGeneral immune activationHTLV-I myelopathySoluble peptide antigenCytokine IL-10IL-10 secretionEpstein-Barr virusAntigen-presenting cellsBlood T cellsInterferon-gamma secretionBest antigen-presenting cellsCytotoxic T cellsEndothelial cells augment the expression of CD40 ligand on newly activated human CD4+ T cells through a CD2/LFA‐3 signaling pathway
Karmann K, Hughes C, Fanslow W, Pober J. Endothelial cells augment the expression of CD40 ligand on newly activated human CD4+ T cells through a CD2/LFA‐3 signaling pathway. European Journal Of Immunology 1996, 26: 610-617. PMID: 8605928, DOI: 10.1002/eji.1830260316.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntigens, Differentiation, T-LymphocyteB-LymphocytesCD2 AntigensCD40 LigandCD4-Positive T-LymphocytesCD58 AntigensCell AdhesionCell CommunicationCells, CulturedEndothelium, VascularHumansInterleukin-2LigandsLymphocyte ActivationMembrane GlycoproteinsPhytohemagglutininsSignal TransductionUp-RegulationConceptsCD40 ligand expressionExogenous IL-2T cellsIL-2Ligand expressionCD2/LFACD40 ligandHuman peripheral blood CD4Peripheral blood adherent cellsHelper T cell subsetsPeripheral blood T cellsPeripheral blood CD4T cell subsetsCo-stimulatory moleculesBlood T cellsHelper T cellsIL-2 receptorCo-stimulatory signalsIL-2 secretionInterleukin-2 secretionBlood CD4Endothelial effectsCell subsetsHuman CD4B cells
1994
Endothelial cell-induced resistance to cyclosporin A in human peripheral blood T cells requires contact-dependent interactions involving CD2 but not CD28.
Karmann K, Pober JS, Hughes CC. Endothelial cell-induced resistance to cyclosporin A in human peripheral blood T cells requires contact-dependent interactions involving CD2 but not CD28. The Journal Of Immunology 1994, 153: 3929-37. PMID: 7523510, DOI: 10.4049/jimmunol.153.9.3929.Peer-Reviewed Original ResearchConceptsIL-2 secretionT cellsEndothelial cellsPeripheral blood T cellsHuman peripheral blood T cellsGraft endothelial cellsHost T cellsBlood T cellsT cell CD28Cultured human endothelial cellsEndothelial cell ligandsIL-2 synthesisInitiation of cocultureContact-dependent interactionsEffect of ECHuman endothelial cellsT cell CD2Presence of ECInhibitory doseLFA-3Cell ligandsCyclosporin ACD28Cell contactSecretionProminent T lymphocyte response to Borrelia burgdorferi from peripheral blood of unexposed donors
Roessner K, Russell J, Cooper S, Budd R, Fikrig E, Flavell R. Prominent T lymphocyte response to Borrelia burgdorferi from peripheral blood of unexposed donors. European Journal Of Immunology 1994, 24: 320-324. PMID: 7905415, DOI: 10.1002/eji.1830240207.Peer-Reviewed Original ResearchConceptsMemory T cellsT cellsPeripheral bloodB. burgdorferiProliferative responseNormal individualsPeripheral blood T cellsT lymphocyte responsesT cell responsesBlood T cellsNaive T cellsNormal adult peripheral bloodHLA-DR moleculesT cell clonesAdult peripheral bloodLyme disease patientsMultiple antigenic epitopesLymphocyte responsesSuperantigen responseUnexposed donorsMemory subsetsDisease patientsCord bloodLipopolysaccharide effectsCell responses
1993
Increased Protein Kinase C Activity in Human Memory T Cells
Höllsberg P, Melinek J, Benjamin D, Hafler D. Increased Protein Kinase C Activity in Human Memory T Cells. Cellular Immunology 1993, 149: 170-179. PMID: 8099849, DOI: 10.1006/cimm.1993.1145.Peer-Reviewed Original ResearchConceptsCD26 T cellsMemory T cellsT cell populationsMemory T cell populationsT cellsT cell receptorProliferative responseCell populationsPeripheral blood T cellsHuman memory T cellsMemory T cell functionCD26 antigen expressionT-cell surface antigensPKC activityBlood T cellsT cell functionTCR/CD3 pathwayDifferentiated T cellsCell surface antigensCD26 mAbCD26- subsetAntigen challengeAntigen expressionCD26 antigenCD26 expression
1991
The coexpression of CD45RA and CD45RO isoforms on T cells during the S/G2/M stages of cell cycle
LaSalle J, Hafler D. The coexpression of CD45RA and CD45RO isoforms on T cells during the S/G2/M stages of cell cycle. Cellular Immunology 1991, 138: 197-206. PMID: 1833074, DOI: 10.1016/0008-8749(91)90144-z.Peer-Reviewed Original ResearchConceptsT cell clonesCell cycleT cellsCD45RA expressionCord bloodTyrosine phosphatase CD45Cell clonesM stageCell cycle stagePHA activationPeripheral blood T cellsCD45RO T cellsCoexpression of CD45RAG2/M stageCD45RA T cellsT cell populationsBlood T cellsG2/M phaseNaive T cellsPhosphatase CD45Propidium iodide stainingHematopoietic cellsM phaseCD45RACD45RO isoform
1990
T‐T cell interactions are mediated by adhesion molecules
Brod S, Purvee M, Benjamin D, Hafler D. T‐T cell interactions are mediated by adhesion molecules. European Journal Of Immunology 1990, 20: 2259-2268. PMID: 1700751, DOI: 10.1002/eji.1830201015.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntigens, Differentiation, T-LymphocyteAntigens, SurfaceCD3 ComplexCD58 AntigensCell Adhesion MoleculesCell CommunicationClone CellsHumansImmunophenotypingInterleukin-2Lymphocyte ActivationLymphocyte Function-Associated Antigen-1Membrane GlycoproteinsMitogensReceptors, Antigen, T-CellT-LymphocytesConceptsT cell clonesAutologous T cell clonesPeripheral blood T cellsAdhesion molecules LFA-1Blood T cellsT cellsLFA-3Major histocompatibility complexInflammatory responseCell clonesICAM-1LFA-1T cell immune functionCD3/T cell receptor complexSpecific T cellsCell adhesion molecules LFA-1Cell immune functionT cell interactionsT cell activationT cell receptor complexMHC determinantsCell receptor complexImmune functionCell activationCD2 pathwayFrequency analysis of CD4+CD8+ T cells cloned with IL-4
Brod S, Purvee M, Benjamin D, Hafler D. Frequency analysis of CD4+CD8+ T cells cloned with IL-4. Cellular Immunology 1990, 125: 426-436. PMID: 2105169, DOI: 10.1016/0008-8749(90)90096-a.Peer-Reviewed Original ResearchConceptsT cell clonesHigh-density CD4Expression of CD8RIL-4IL-2CD8 expressionT cellsIL-4CD8 moleculesCD4 expressionCell clonesPeripheral blood T cellsHigh density CD8Low CD8 expressionSurface CD8 expressionLectin-dependent cytotoxicitySurface of CD4Blood T cellsPattern of CD4Class I MHCNK activityPeripheral bloodCell surface expressionInflammatory responseCD8FcR-mediated crosslinking of Ta1 (CDw26) induces human T lymphocyte activation
Dang N, Hafler D, Schlossman S, Breitmeyer J. FcR-mediated crosslinking of Ta1 (CDw26) induces human T lymphocyte activation. Cellular Immunology 1990, 125: 42-57. PMID: 2152856, DOI: 10.1016/0008-8749(90)90061-u.Peer-Reviewed Original ResearchConceptsCD3/T cell receptor complexHuman T lymphocyte activationT lymphocyte activationT cellsT cell receptor complexCell receptor complexLymphocyte activationPeripheral blood T cellsMonoclonal antibodiesCytolytic effector functionExogenous IL-2Blood T cellsIL-2 receptorPositive accessory cellsT cell clonesT cell activationReceptor complexHuman T lymphocytesT cell regulatory networkAnti-Ta1Recall antigensPeripheral bloodIL-2T lymphocytesEffector functions
1989
Mechanisms of immune memory. T cell activation and CD3 phosphorylation correlates with Ta1 (CDw26) expression.
Hafler DA, Chofflon M, Benjamin D, Dang NH, Breitmeyer J. Mechanisms of immune memory. T cell activation and CD3 phosphorylation correlates with Ta1 (CDw26) expression. The Journal Of Immunology 1989, 142: 2590-6. PMID: 2564857, DOI: 10.4049/jimmunol.142.8.2590.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, Differentiation, T-LymphocyteAntigens, SurfaceCalciumCD2 AntigensCD3 ComplexHumansImmunologic MemoryLymphocyte ActivationPhosphorylationProtein Kinase CReceptors, Antigen, T-CellReceptors, ImmunologicTetradecanoylphorbol AcetateT-LymphocytesTumor Necrosis Factor Receptor Superfamily, Member 7ConceptsT cell immune memoryT cell activationImmune memoryT cellsCell activationPeripheral blood T cellsTA1 expressionBlood T cellsIntracellular calcium levelsTA1 cellsCD3/TCRT cell linesCalcium ionophore ionomycinAg challengeIL-2T lymphocytesMitogenic antibodiesCalcium levelsPhorbol ester PMAIonophore ionomycinCD2 moleculeGrowth factorActivation requirementsInvariant chainCD2 stimulation
1987
In vivo labeling of blood T cells: Rapid traffic into cerebrospinal fluid in multiple sclerosis
Hafler D, Weiner H. In vivo labeling of blood T cells: Rapid traffic into cerebrospinal fluid in multiple sclerosis. Annals Of Neurology 1987, 22: 89-93. PMID: 3498435, DOI: 10.1002/ana.410220121.Peer-Reviewed Original ResearchConceptsCentral nervous systemProgressive multiple sclerosisMultiple sclerosisBlood T cellsT cellsCerebrospinal fluidMurine monoclonal antibodiesSheep red blood cell receptorTreatment of MSPeripheral blood T cellsRed blood cell receptorsMonoclonal antibodiesCSF T cellsSerial lumbar puncturesPeripheral immune systemOngoing pathological processAnti-T4MS patientsDaily infusionsLumbar puncturePeripheral bloodInflammatory diseasesCSF specimensNervous systemImmune system
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